A link between the COVID-19 pandemic and Kawasaki-like multi-system inflammatory syndrome in children
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Pediatrics Department, National Research Centre, Cairo, Egypt
Manal Fouad Elshamaa   

33 Elbohous street, Dokki, Cairo, Egypt, postal code,12311, Pediatrics Department,National Research Centre
J Pre Clin Clin Res. 2020;14(4):151–155
COVID-19 (coronavirus disease 2019) – the epidemic outbreak caused by coronavirus-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – is a global public health problem. Children are less affected and have a mild form of the illness. The association between SARS-CoV-2 disease, COVID-19 and late symptoms of vasculitis is often suspected, in particular in young asymptomatic patients, especially due to the post-viral immune response.

The aim of the review is to describe the characteristics of children and adolescents affected by the development of Kawasaki-like mult-system inflammatory syndrome (KD) (MISC), and assesses its possible temporal association with SARS-CoV-2 infection

Brief description of the state of knowledge:
A group of children who presented with KD-type MISC during the COVID-19 pandemic have been identified in the United Kingdom, the United States, and Italy. Some children were diagnosed with SARS-CoV-2 infection by real-time polymerase chain reaction and IgG antibodies. SARS-CoV-2 infection and hyperinflammation in COVID-19 can serve as an ‘initial trigger’ for KD. IVIG should be administered within seven days of onset of illness until KD symptoms disappear and COVID-19 test is negative. Large numbers of children in African countries with the SARS-CoV-2 epidemic are likely to be affected by KD, and in such cases, a shortage of IVIG supplies is expected.

This article suggests a correlation between COVID-19 and Kawasaki-like MISC, which is important for the care of sick children. However, the definitive relationship between childhood KD and COVID-19 needs to be confirmed by a large cohort study on a large numbers of infant and children patients worldwide.

The author thanks the National Research Centre in Cairo, Egypt.
The author declares that there are no conflicts of interest.
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