Pruritus in liver disease – pathenogenisis and treatment

Andrzej Prystupa 2  ,  
Student Scientific Association, Department of In ternal Medicine, Medical University, Lublin, Poland
Chair and Department of Internal Medicine, Medical University, Lublin, Poland
JPCCR 2011;5(2):47–49
Pruritus often constitutes a most irritating ailment in patients suffering from chronic liver diseases, especially when cholestasis plays a prominent role. The exact pathogenesis is not entirely recognized. Nevertheless, several mechanisms have been proposed: pruritus connected with a central/peripheral origin, itch caused by mast cells’ hyperactivity, or determined by the intrahepatic cholestasis of pregnancy. This article concentrates on the pruritus accompanying advanced liver disorders. Its pathogenesis and treatment are also discussed.
Andrzej Prystupa   
Chair and Department of Internal Medicine, Medical University, Lublin, Staszica 16, 20-081 Lublin, Poland.
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