REVIEW PAPER
Quercetin: health benefits with relevance to TNF-α-linked inflammatory diseases
 
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1
Section for Biochemistry and Physiology, Department of Animal and Veterinary Basic Sciences, Faculty of Life Sciences, Copenhagen University, Denmark
 
2
Physiology Division, Birmingham City University, Birmingham, England
 
 
Corresponding author
Adrian P. Harrison   

Section for Biochemistry and Physiology, Department of Animal and Veterinary Basic Sciences, Faculty of Life Sciences, Copenhagen University, 1870 Frederiksberg C, Denmark.
 
 
J Pre Clin Clin Res. 2008;2(2):97-101
 
KEYWORDS
ABSTRACT
With increasing interest among the general public for using natural and herbal remedies, there is a great need to document and list ancient medical texts and practices, as well as to investigate the efficacy of a number of ‘ancient’ compounds that are currently reputed to have medicinal benefits for such diseases as arthritis, wound healing, cancer, chronic inflammation and cardiovascular disease. With these goals in mind, we have collected evidence for the use of the natural polyphenolic flavonoid quercetin in antiquity, as well as identified modern clinical research showing the efficacy of this compound for human health. Our report not only provides clear evidence for the flavonoid quercetin as an anti-inflammatory, which may well have been used in antiquity to treat arthritic swelling and pain, it also serves to re-educate the general public and scientific community to the fact that natural and herbal remedies can be very efficacious forms of medication, deserving respect.
REFERENCES (41)
1.
Pirmohamed M, James S, Meakin S, Park BK, Breckenridge AM, Green C, Scott AK, Walley TJ, Farrar K: Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ 2004; 329: 15-19.
 
2.
Kang-Yum E, Kurt TL, Smolinske S: Toxicity and drug interactions of herbs and dietary supplements. Clin Toxicol 2006; 44: 603.
 
3.
lsus C, De Medicina: The Loeb Classical Library (transl. by Spencer WG). Harvard University Press, Cambridge, Massachusetts, Book II 18(3), 1935, pp. 193.
 
4.
Dioscorides P. De Materia Medica. A new indexed version in modern English. Osbaldeston TA (Ed.), Wood RPA (Researcher). Ibidis Press, Johannesburg 2000, pp. 932.
 
5.
Allen JP: The Art of Medicine in Ancient Egypt – The Metropolitan Museum of Art, Yale University Press, New Haven & London 2005, pp. 115.
 
6.
International Classifi cation of Functioning, Disability and Health. World Health Organization, Geneva 2001, pp. 1-11.
 
7.
Manniche L: An ancient Egyptian herbal. The British Museum Press, London 1989, pp. 147-148.
 
8.
Bircher AF, Bircher WH: Encyclopedia of fruit trees and edible fl owering plants in Egypt and the Subtropics. The American University in Cairo Press, Cairo 2000, pp. 382.
 
9.
Hollman PC, van Trijp JM, Buysman MN, van der Gaag MS, Mengelers MJ, de Vries JH, Katan MB: Relative bioavailability of the antioxidant fl avonoid Quercetin from various foods in man. FEBS Lett 1997, 418(1- 2), 152-156.
 
10.
Hollman PC, vd Gaag M, Mengelers MJ, Trijp JM, de Vries JH, Katan MB: Absorption and disposition kinetics of the dietary antioxidant Quercetin in man. Free Radic Biol Med 1996, 21(5), 703-707.
 
11.
McAnlis GT, McEneny J, Pearce J, Young IS: Absorption and antioxidant eff ects of Quercetin from onions, in man. Eur J Clin Nutr 1999, 53(2), 92-96.
 
12.
Hollman PC, van Het Hof KH, Tijburg LB, Katan MB: Addition of milk does not aff ect the absorption of fl avonols from tea in man. Free Radic Res 2001, 34(3), 297-300.
 
13.
Hubbard GP, Wolff ram S, de Vos R, Bovy A, Gibbins JM, Lovegrove JA: Ingestion of onion soup high in Quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study. Br J Nutr 2006, 96(3), 482-488.
 
14.
Jaganath IB, Mullen W, Edwards CA, Crozier A: The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man. Free Radic Res 2006, 40(10), 1035-1046.
 
15.
Hollman PC, Katan MB: Bioavailability and health eff ects of dietary fl avonols in man. Arch Toxicol Suppl 1998, 20, 237-248.
 
16.
Fiorani M, Accorsi A: Dietary fl avonoids as intracellular substrates for an erythrocyte trans-plasma membrane oxidoreductase activity. Br J Nutr 2005, 94(3), 338-345.
 
17.
Young JF, Nielsen SE, Haraldsdottir J, Daneshvar B, Lauridsen ST, Knuthsen P, Crozier A, Sandstrom B, Dragsted LO: Eff ect of fruit juice Nair MP, Mahajan S, Reynolds JL, Aalinkeel R, Nair H, Schwartz SA, Kandaswami C: The fl avonoid Quercetin inhibits proinfl amatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-κβ system. Clin Vaccine Immunol 2006, 13, 319-328.
 
18.
Aggarwal BB: Signalling pathways of the TNF superfamily: a doubleedged sword. Nat Rev Immunol 2003; 3: 745-756.
 
19.
Moore RJ, Owens DM, Stamp G, Arnott C, Burke F, East N, Holdsworth H, Turner L, Rollins B, Paspavakis MKollias G, Balkwil F: Mice defi cient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nat Med 1999, 5, 828-831.
 
20.
Sugarman BJ, Aggarwal BB, Hass PE, Figari IS, Palladino MA JR, Shepard HM: Recombinant human tumor necrosis factor-alpha: eff ects on proliferation of normal and transformed cells in vitro. Science 1985, 230, 943-945.
 
21.
Malaveille C, Hautefeuille A, Pignatelli B, Talaska G, Vineis P, Bartsch H: Dietary phenolics as anti-mutagens and inhibitors of tobacco-related DNA adduction in the urothelium of smokers. Carcinogens 1996, 17(10), 2193-2200.
 
22.
Kowalski J, Samojedny A, Paul M, Pietsz G, Wilczak T: Eff ect of apigenin, kaempferol and resveratrol on the expression of interleukin- 1beta and tumor necrosis factor-alpha genes in J774.2 macrophages. Pharmacol Rep 2005, 57, 390-394.
 
23.
Jackson JK, Higo T, Hunter WL, Burt HM: The antioxidants curcumin and Quercetin inhibit infl ammatory processes associated with arthritis. Infl amm Res 2006, 55, 168-175.
 
24.
Tudan C, Jackson JK, Higo TT, Burt HM: The eff ect of inhibiting ,topoisomerase I and II on the anti-apoptotic response associated with pro-infl ammatory crystals of calcium pyrophosphate dihydrate in human neutrophils. Infl amm Res 2003, 52, 8-17.
 
25.
O´Dell JR: Methotrexate use in rheumatoid arthritis. Rheum Dis Clin North Am 1997, 23, 779-796.
 
26.
Reid C, Smith K, Kocha W: Case Report: Quercetin/bromelain use ,associated with increased liver enzymes. J Oncol Pharm Practice 2004, 10, 225-227.
 
27.
Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ: A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981, 30, 239-245.
 
28.
Singh A, Naidu PS, Kulkarni SK: Quercetin, a biofl avonoid, reverses development of tolerance and dependence to morphine. Drug Devel Res 2002, 57, 167-172.
 
29.
Scoto GM, Spadaro C, Spampinato S, et al.: Prostaglandins in rat placenta following acute and chronic administration of morphine. Arch Toxicol Suppl 1979, 2, 375-380.
 
30.
Johnson MA, Hill RG, Hughes J: A possible role for prostaglandins in the expression of morphine dependence in guinea pig isolated ileum. Br J Pharmacol 1988, 93, 932-936.
 
31.
Boots AW, Li H, Schins RP, Duffi n R, Himskerk JW, Bast A, Haenen GR: The Quercetin paradox. Toxicol Appl Pharmacol 2007, 222, 89- 96.
 
32.
Boots AW, Haenen GRMM, Bast A: Health eff ects of Quercetin: From antioxidant to nutraceutical. Euro J Pharmacol 2008, 585, 325-337.
 
33.
Hollman PC, vd Gaag M, Mengelers MJ, Trijp JM, de Vries JH, Katan MB: Absorption and disposition kinetics of the dietary antioxidant quercetin in man. Free Radic Biol Med 1996, 21, 703-707.
 
34.
Conquer JA, Maiani G, Azzini E, Raquzzini A, Holub BJ: Supplementation with quercetin markedly increases plasma quercetin concentration without eff ect on selected risk factors for heart disease in healthy subjects. J Nutr 1998, 128, 593-597.
 
35.
Moon YJ, Wang L, DiCenzo R, Morris ME: Quercetin pharmacokinetics in humans. Biopharm Drug Dispos 2008, 29, 205-217.
 
36.
Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, Jalili T: Quercetin reduces blood pressure in hypertensive subjects. J Nutr 2007, 137, 2405-2411.
 
37.
Moller DR: Cells and cytokines involved in the pathogenesis of sarcoidosis. Sarcoidosis Vasc Diff use Lung Dis 1999, 16, 24-31.
 
38.
Pliny GP. Natural History. The Loeb Clasical Library, Book XV 59 (transl. by Rackham H). Harvard University Press, Cambridge (USA) 1925.
 
39.
Son YO, Kook SH, Choi KC, jang YS, Choi YS, Jeon YM, Kim JB, Hwang HS, Lee JC: Quercetin accelerates TNF-α-induced apoptosis of MC3T3- E1 osteoblastic cells through caspase-dependent and JNK-mediated pathways. Euro J Pharmacol 2008, 579, 26-33.
 
40.
Wattel A, Kamel S, Mentaverri R, Lorget F, Prouillet C, Petit JP, Fardelonne P, Brazier M: Potent inhibitory eff ect of naturally occurring fl avonoids quercetin and kaempferol on in vitro osteoclastic bone resorption. Biochem Pharmacol 2003, 65, 35-42.
 
41.
Saaby L, Rasmussen HB, Jager AK: MAO-A inhibitory activity of quercetin from Calluna vulgaris (L.) Hull. J Ethnopharmacology 2009, 121, 178-181.
 
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