A review of selected natural phytochemicals in preventing and treating malignant skin neoplasms
More details
Hide details
Department of Medical Biology and Translational Research, Faculty of Medicine, University of Information Technology and Management, Rzeszow, Poland
Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland
Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland
Corresponding author
Dominika Furman-Toczek   

Department of Medical Biology and Translational Research, Faculty of Medicine, University of Information Technology and Management, Rzeszow, Poland
J Pre Clin Clin Res. 2016;10(2):127-130
Malignant skin neoplasms are one of the most common human malignancies. The incidence of nonmelanoma skin cancers and malignant melanoma is constantly increasing. The current therapies, especially for malignant melanoma, have relatively low success rates. Therefore, there is an urgent need to develop new remedies that are both safe and effective. Natural substances have always been an important source for the discovery of new therapies. In turn, a number of studies have indicated that some phytocheicals could have an anti-tumour effect. In vitro and in vivo testing of malignant skin neoplasm models revealed different anti-tumour actions, including antioxidation, carcinogen inactivation, anti-proliferation, cell cycle arrest, induction of apoptosis, inhibition of angiogenesis, or a combination of them. The aim of this paper is to describe anti-tumour compounds derived from natural sources that might be used in the therapy of malignant skin neoplasm. The phytochemicals discussed below include carotenoids, terpenoids and flavonoids.
World Human Organization (access: 2016.12.05).
Kasper M, Jaks V, Hohl D, Toftgård R. Basal cell carcinoma–molecular biology and potential new therapies. J Clin Invest. 2012; 122(2): 455–463.
Skin Cancer Foundation (access: 2016.12.05).
Ramaya Silpa S, Chidvila V. A review on skin cancer. Int Res J Pharm. 2013; 4(8): 83–88.
Lo JA, Fisher DE. The melanoma revolution: from UV carcinogenesis to a new era in therapeutics. Science. 2014; 346(6212): 945–949.
Narayanan DL, Saladi RN, Fox JL. Review: Ultraviolet radiation and skin cancer. Int J Dermatol. 2010; 49(9): 978–986.
Saladi RN, Persaud AN. The causes of skin cancer: a comprehensive review.Drugs Today (Barc). 2005; 41(1): 37–53.
Pfister H. Chapter 8: Human Papillomavirus and Skin Cancer. J Natl Cancer Inst Monogr. 2003; 31: 52–56.
Euvrard S, Kanitakis J, Claudy A. Skin Cancers after Organ Transplantation. N Engl J Med. 2003; 348: 1681–691.
Chicheł A, Skowronek J. Contemporary management of skin cancer – dermatology, surgery or radiotherapy?. Współcz Onkol. 2005; 9(10): 429–435.
Molassiotis A, Fernadez-Ortega P, Pud D, Ozden G, Scott JA, Panteli V, et al. Use of complementary and alternative medicine in cancer patients: a European survey. Ann Oncol. 2005; 16(4): 655–663.
Sharma H, Parihar L, Parihar P. Review on cancer and anticancerous properties of some medicinal plants. J Med Plant Res. 2011; 5(10): 1818–1835.
Tan W, Lu J, Huang M, Li Y, Chen M, Wu G et al. Anti-cancer natural products isolated from chinese medicinal herbs. Chin Med. 2011; 6: 27.
Cragg GM, Newman DJ. Natural products: a continuing source of novel drug leads. Biochim Biophys Acta. 2013; 1830(6): 3670–3695.
Liu RH. Potential Synergy of Phytochemicals in Cancer Prevention: Mechanism of Action. J Nutr. 2004; 134: 3479–3485.
Cazzonelli CI. Carotenoids in nature: insights from plants and beyond. Fun Plant Biol. 2011; 38(11): 833–847.
Gryszczyńska A, Gryszczyńska B, Opala B. Carotenoids. Natural sources, biosynthesis, influence on human body. Post Fitoter. 2011; 2: 127–143.
Palozza, P, Serini S, Torsello A, di Nicuolo F, Maggiano N, Ranelletti FO, et al. Mechanism of activation of caspase cascade during β-carotene-induced apoptosis inhuman tumor cells. Nutr Cancer. 2003; 47: 76–87.
Guruvayoorappan C, Kuttan G. Beta – carotene inhibits tumor-specific angiogenesis by altering the cytokine profile and inhibits the nuclear translocation of transcription factors in B16F-10melanoma cells. Integr Cancer Ther. 2007; 6: 258–270.
Greenberg ER, Baron JA, Stukel TA, Stevens MM, Mandel JS, Spencer SK, et al. A clinical trial of beta carotene to prevent basal-cell and squamous-cell cancers of the skin. The Skin Cancer Prevention Study Group. N Engl J Med. 1990; 323(12):789–795.
Hennekens CH. Lack of Effect of Long-Term Supplementation with Beta Carotene on the Incidence of Malignant Neoplasms and Cardiovascular Disease. N Engl J Med. 1996; 334: 1145–1149.
Millen AE, Tucker MA, Hartge P. Diet and Melanoma in a Case-Control Study. Cancer Epidemiol Biomarkers Prev. 2004; 13(6): 1042–1052.
Wang G, Tang W, Bidigare RR. Terpenoids As Therapeutic Drugs and Pharmaceutical Agents. In: Zang L, Demain AL, editors. Natural Products: Drug discovery and Theraputic Medicine. Totowa: Humana Press; 2005. p. 197–227.
Ireland DJ, Greay SJ, Hooper CM, Kissick HT, Filion P, Riley TV, et al. Topically applied Melaleuca alternifolia (tea tree) oil causes direct anti-cancer cytotoxicity in subcutaneous tumour bearing mice. J Dermatol Sci. 2012; 67(2): 120–129.
Muto Y, Ninomiya M, Fujiki H. Present status of research on cancer chemoprevention in Japan. Jpn J Clin Oncol. 1990; 20(3): 219–224.
Trajkovic LMH, Mijatovic SA, Maksimovic-Ivanic DD, Stojanovic ID, Momcilovic MB, Tufegdzic SJ, et al. Anticancer Properties of Ganoderma Lucidum Methanol Extracts In Vitro and In Vivo. Nutr Cancer. 2008; 61(5): 696–707.
Yao LH, Jiang YM, Shi J, Tomás-Barberán FA, Datta N,Singanusong R, et al. Flavonoids in food and their health benefits. Plant Foods Hum Nutr. 2004; 59(3): 113–122.
Ren W, Qiao Z, Wang H, Zhu L, Zhang L. Flavonoids: Promising Anticancer Agents. Med Res Rev. 2003; 23(4): 519–534.
Rawson NE, Ho Ch-T,Li S. Efficacious anti-cancer property of flavonoids from citrus peels. Food Sci Hum Wellness. 2014; 3(3–4): 104–109.
Cibin TR, Devi DG, Abraham A. Chemoprevention of skin cancer by the flavonoid fraction of Saracaasoka. View issue TOC. 2010; 24(5): 666–672.
Singh RP, Agarwal R. Flavonoid antioxidant silymarin and skin cancer. Antioxid Redox Signal. 2002; 4(4): 655–663.
Journals System - logo
Scroll to top