REVIEW PAPER
Impact of CCR5-inhibitors on cancer treatment: A systematic review of preclinical evidence
1
Graduate Programme in Biological Sciences, Federal University, Alfenas (UNIFAL-MG), Brazil
2
Department of Oral Diagnosis, School of Dentistry, University of Campinas (UNICAMP), Brazil
3
Laboratory of Molecular Biology and Cell Culture (LBMCC), Faculty of Medicine of Jundiaí (FMJ), Brazil
4
Graduate Programme in Health Sciences, Faculty of Medicine of Jundiaí (FMJ), Brazil
5
Departmentof Oral Diagnosis, School of Dentistry, University of Campinas (UNICAMP), Brazil
6
Graduate Programme in Oral Biology, School of Dentistry, University of Campinas (UNICAMP), Brazil
7
Departament of Pathology and Parasitology, Federal University of Alfenas (UNIFAL-MG), Brazil
Corresponding author
Carine Ervolino de Oliveira
Departament of Pathology and Parasitology, Federal University of Alfenas (UNIFAL-MG), Rua Gabriel Monteiro da Silva, 700, 37130-000, Alfenas, Brazil
Departament of Pathology and Parasitology, Federal University of Alfenas (UNIFAL-MG), Rua Gabriel Monteiro da Silva, 700, 37130-000, Alfenas, Brazil
KEYWORDS
TOPICS
ABSTRACT
Introduction and objective:
In view of the role of the CCR5 chemokine receptor in tumour development and progression, researchers have investigated the effects of its inhibition in different types of cancer. Although promising results have been reported, the efficacy, safety, and methodological quality of the studies need to be analyzed before their application in clinical practice. The aim of this review is to evaluate the approaches used to inhibit CCR5 and assess its effects on cancer development. Additionally, the methodological quality of preclinical animal studies aree evaluated.
Review methods:
A systematic review was performed according to PRISMA guidelines retrieving, and analyzing 19 original studies. To analyze the risk of bias and quality of the preclinical studies, the SYRCLE tool (Systematic Review Centre for Laboratory Animal Experimentation) was used.
Brief description of the state of knowledge:
Despite the wide methodological variability found in the reviewed studies, some common characteristics were observed. Most experiments (73.68%; n=14) used immunosuppressed mice in their induction models, and the response to CCR5 inhibition was primarily assessed by measuring tumour size. Maraviroc (MVC) was the most frequently used CCR5 inhibitor (73.68%; n=14).
Summary:
The results provided significant evidence that CCR5 inhibition is a promising target for cancer treatment. However, by mapping the risk of bias across all investigated studies, this review provides objective support for guiding future research with more rigorous methodologies, ensuring clear evidence of the impact of CCR5 inhibition on cancer development and progression.
In view of the role of the CCR5 chemokine receptor in tumour development and progression, researchers have investigated the effects of its inhibition in different types of cancer. Although promising results have been reported, the efficacy, safety, and methodological quality of the studies need to be analyzed before their application in clinical practice. The aim of this review is to evaluate the approaches used to inhibit CCR5 and assess its effects on cancer development. Additionally, the methodological quality of preclinical animal studies aree evaluated.
Review methods:
A systematic review was performed according to PRISMA guidelines retrieving, and analyzing 19 original studies. To analyze the risk of bias and quality of the preclinical studies, the SYRCLE tool (Systematic Review Centre for Laboratory Animal Experimentation) was used.
Brief description of the state of knowledge:
Despite the wide methodological variability found in the reviewed studies, some common characteristics were observed. Most experiments (73.68%; n=14) used immunosuppressed mice in their induction models, and the response to CCR5 inhibition was primarily assessed by measuring tumour size. Maraviroc (MVC) was the most frequently used CCR5 inhibitor (73.68%; n=14).
Summary:
The results provided significant evidence that CCR5 inhibition is a promising target for cancer treatment. However, by mapping the risk of bias across all investigated studies, this review provides objective support for guiding future research with more rigorous methodologies, ensuring clear evidence of the impact of CCR5 inhibition on cancer development and progression.
FUNDING
Fundação de Amparo à Pesquisa do Estado de Minas Gerais – FAPEMIG, Minas Gerais, Brazil (APQ-00319-18), Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq, Brasília, Brazil (421895/2018-7), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES.
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