Conjugated linoleic acid has no effects on atherosclerosis but induces liver steatosis in apoE/LDLR -/- mice fed a fructose-rich diet
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Department of Human Nutrition, Faculty of Food Technology, Agricultural University, Cracow, Poland
Department of Histology, Jagiellonian University Medical College, Cracow, Poland
Department of Experimental Pharmacology, Jagiellonian University Medical College, Cracow, Poland
J Pre Clin Clin Res. 2010;4(2):118–121
The current study was designed to investigate the effects of CLA on several known risk factors of atherosclerosis in apoE/LDLR-/- mice fed fructose diet. The mice at the age of 2 months were divided into 2 experimental groups and fed the following diets: I- AIN-93G + 60% fructose (Fructose) and II- AIN-93G + 60% fructose + 0.5% CLA (Fructose+CLA). After 2 months of feeding, plasma lipid profile, glucose concentration, liver fatty acid composition, and quantification of atherosclerosis were analyzed. There were no differences in body and kidney weight. Liver weight was significantly increased in the CLA-treatment group which was related to higher liver lipid concentration. No changes in plasma lipid profile nor liver fatty acid composition were observed between experimental groups. These results indicate that CLA increased liver lipid accumulation. It may cause liver steatosis in experimental mice.
Renata B. Kostogrys
Department of Human Nutrition, Faculty of Food Technology, Agricultural University, Balicka 122, 30-149 Cracow, Poland.
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