Clinical usefulness of determining C-reactive protein and fibrinogen concentrations and lipid profile in blood serum of patients undergoing surgery due to atherosclerosis
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Department of Surgery, Railway Hospital, Lublin, Poland
Department of Virology and Immunology, Institute of Microbiology and Biotechnology, Maria Curie-Skłodowska University, Lublin, Poland
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Piotr Niedziela   

Railway Hospital, Department of Surgery, Kruczkowskiego 21, 20- 468 Lublin, Poland.
J Pre Clin Clin Res. 2008;2(1):75-79
Determination of basic blood biochemical parameters are used as a measure taken in atherosclerosis prophylaxis, or is performed depending on the complications found in the course of the disease. The aim of the study was to find diff erences between basic biochemical parameters measured in blood serum of patients with atherosclerosis. The study comprised 52 men, who were divided into three groups depending upon the type of surgical procedure performed due to atherosclerosis on internal carotid artery, aortic – iliac section and femoral – popliteal section of the femoral artery. The serum concentration of C-reactive protein was determined with the use of the rocket immunoelectrophoresis method (RI). The levels of total cholesterol, its HDL and LDL fractions and triglycerides were measured by the immunoenzymatic method (ELISA). Fibrinogen level was determined according to Clauss’s and ELISA tests. Total cholesterol, HDL and LDL fractions and triglycerides remained within the norm. Performed biochemical examinations did not significantly differ between the analysed groups of patients. Collective analysis of the correlation coefficient between the analysed parameters showed that the serum triglyceride concentration decreases with the patients’ age. An increase in the acute phase protein concentration was accompanied by a decrease in the concentrations of total cholesterol, LDL and triglycerides. The above relationship was not found in the case of HDL fraction of cholesterol. The results show that the biochemical determinations performed in blood serum of patients with atherosclerosis are not dependent on the location of an obliterated vessel. The significant parameters in this analysis are the acute phase protein concentration (CRP) and the fibrinogen level.
Langheinrich AC, Bohle RM: Atherosclerosis: humoral and cellular factors of infl ammation. Virchows Arch 2005, 446, 101-111.
Lindholt JS, Fasting H, Henneberg EW, Řstergaard L: A review of Chlamydia pneumoniae and atherosclerosis. Eur J Vasc Endovasc Surg 1999, 17, 283-289.
Slater J, Rill V: Coronary artery disease: new insights into the pathophysiology, prevalence, and early detection of a monster menace. Semin Ultrasound CT MRI 2004, 25, 113-121.
Selzman CH, Miller SA, Harken AH: Therapeutic implications of infl ammation in atherosclerotic cardiovascular disease. Ann Thorac Surg 2001, 71, 2066-2074.
Gerrity RG, Antonov AS: The pathogenesis of atherosclerosis. Diabetologia 1997, 40, S108-S110.
Tarchalski J, Guzik P, Wysocki H: Correlation between the extent of coronary atherosclerosis and lipid profi le. Mol Cell Biochem 2003, 246, 25-30.
Frost PH, Havel RJ: Rationale for use of non-high-density lipoprotein cholesterol rather than low-density lipoprotein cholesterol as a tool for lipoprotein cholesterol screening and assessment of risk and therapy. Am J Cardiol 1998, 81, 26B-31B.
Laurell CB: Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal Biochem 1966, 15, 45-52.
Clauss A: Gerinnungsphysiologische Schnellmethode zur Bestimmung des fi brinogens. Acta Haematol 1957, 17, 237-246.
Takahashi K, Takeya M, Sakashita N: Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animals. Med Electron Microsc 2002, 35, 179-203.
Tertov VV, Orekhov AN: Metabolism of native and naturally occurring multiple modifi ed low density lipoprotein in smooth muscle cells of human aortic intima. Exp Mol Pathol 1997, 64, 127-145.
Marutsuka K, Hatakeyama K, Yamashita A, Asada Y: Role of thrombogenic factors in the development of atherosclerosis. J Atheroscler Thromb 2005, 12, 1-8.
Li J-J, Fang Ch-H: Atheroscleritis is a more rational term for the pathological entity currently known as atherosclerosis. Med Hypotheses 2004, 63, 100-102.
Haverkate F: Levels of haemostatic factors, atherosclerosis and cardiovascular disease. Vasc Pharm 2002, 39, 109-112.
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