Osmotic demyelination syndrome (ODS) is a non-inflammatory disorder of the central nervous system that arises from osmotic disturbances, particularly related to the rapid correction of chronic ionic imbalances, especially concerning sodium levels. ODS has been shown as an interdisciplinary problem which requires the collaboration of many specialists to achieve successful goals. This case study describes a 46-year-old male patient with a history of chronic alcohol abuse and other underlying health issues, including sodium imbalances. The patient required extensive care, spanning multiple departments – emergency, neurology, psychiatry, and detoxification, over a prolonged hospitalization of 80 days. The patient presented multiple symptoms, including recurrent respiratory disorders requiring intubation. Even with increasing improvements in management, osmotic demyelination syndrome still presents significant therapeutic challenges. Standardized treatment guidelines remain lacking.