Protective role of curcumin in maximal electroshock induced seizures, memory impairment and neurotransmitters in rat brain
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Department of Pharmacology, Bapatla College of Pharmacy, Bapatla, Andhra Pradesh, India
Carism, Sastra Univerisity, Thanjavur, Tamil Nadu, India
Corresponding author
Chimakurthy Jithendra   

Department of Pharmacology, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), AP, India-5522124.
J Pre Clin Clin Res. 2008;2(1):35-39
Central nervous system disorders are of great concern in the present day world due to increasing stress and changing living conditions. Since epilepsy is one of the most prevalent CNS disorders, and as a number of side effects are associated with the present antiepileptic drug treatments, the presented research was designed to evaluate the effect of curcumin on generalized tonic clonic (GTC) seizures, together with its eff ect on memory retention in seizure induced rats, and the role of monoamines in protection from seizures and memory impairment. To investigate the effect on GTC, Maximal electro shock (150mA intensity for 0.2 sec) was administered using electro convulsiometer after 14 days of treatment with curcumin (5 and 10 mg/kg). Rats were trained for conditioned avoidance response before the initiation of treatment, and the effect on memory was studied after the induction of epilepsy using a conditioned avoidance response task. Fluorimetric estimations of norepinephrine, dopamine and serotonin in cerebral cortex, cerebellum, hippocampus, pons and hypothalamus made it evident that curcumin exerted a potential antiepileptic and memory retentive effects, with considerable influence on the brain monoamine levels.
Ndoye N, Sow A, Diop A, Sessouma B, Sene diouf F, Boissy L, Wone I, Toure K, Ndiaye M, Ndiaye P: Prevalence of epilepsy its treatment gap and knowledge, attitude and practice of its population in suburban Senegal an ILAE/IBE/WHO study. Seizure 2005, 14, 7-12.
Kulkarni SK, George B: Signifi cance of long term potentiation in cognitive functions and epilepsy. Ind J Pharmacol 1999, 31, 14-22.
Carpy JA, Aldenkamp AP, Cavan DS: Complaints associated with the use of antiepileptic drugs – results from a community based study. Eur J Epilepsy 2005, 14, 67-75.
Srinivas V, Haranath babu M, Narendra Reddy T, Diwan AV: Modulation of neuotransmitters in mice brains by an anticonvulsant principle from cuttle bone. Ind J Pharmacol 1997, 29, 296-300.
Mann DM, Yates PO, Hawkes J: The noradrenergic system in Alzheimer and multi-infarct dementias. J Neurol Neurosurg Psychiatry 1982, 45, 113-119.
Ringman JM, Frautschy SA, Cole GM, Masterman DL, Cummings JL: A potential role of the curry spice curcumin in Alzheimer’s disease. Curr Alzheimer Res 2005, 2, 131-136.
Yu ZF, Kong LD, Chen Y: Antidepressant activity of aqueous extracts of Curcuma longa in mice. J Ethnopharmacol 2002, 83, 161-165.
Sharma PC, Yelne MB, Dennis: Database on medicinal plants used in ayurveda (1st ed.). Central council for research in ayurveda and siddha, New Delhi 2002, 152-178.
Fellows EJ, Cook L: Conditioned avoidance response in psychotropic drugs. Ed., Gourattini S and Ghetti V. Elsevier, Amsterdam 1982, 396.
Turner RA: Anticonvulsants. In: Screening procedures in pharmacology, Academic Press, New York 1972, 163-173.
Balakrishnan S, Pandhi P, Bhargava VK: Eff ects of Nimodipine on the effi cacy of commonly used antiepileptic drugs in rats. Ind J Exp Biol 1998, 36, 51-54.
Ravindran R, Sheela Devi R, Samson J, Senthilvelan M: Noise stress induced brain neurotransmitter changes and the eff ect of Ocimum sanctum Linn treatment in albino rats. Jap Phamacol Sci 2005, 98, 354-360.
Kari HP, Davidson PP, Herbert HH, Kochbar MH: Eff ects of ketamine on brain monoamine levels in rats. Res Comm Chem Path Pharmacol 1978, 20, 475-488.
Dolphin AC: Noradrenergic modulation of glutamate release in the cerebellum. Brain Res 1982, 252, 111-116.
Caspers H, Speckman EJ: Cerebral PO2, PCO2 and pH: changes during convulsive activity and their signifi cance for spontaneous arrest of seizures. Epilepsia 1972, 13, 699-725.
Ying Xu, Bao Shan Ku, Hai Yan Yao, Yan Hua Lin, Xing Ma, Yong He Zhang, Xue Jun Li: Antidepressant eff ects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Pharmacol Biochem Behav 2005, 82, 200-206.
Sharma A, Parikh V, Singh M: Pharmacological basis of drug therapy of Alzheimer’s disease. Ind J Exp Biol 1997, 35, 1146-1155.
Kazue Takahato, Akikominami, Haruko Kusumoto, Seilchiro Shimazu, Fumio Yoneda: Eff ects of selegelline alone or with donepzil on memory impairment in rats. Eur J Pharmacol 2005, 518, 140-144.
Marie RM, Defer GL: Working memory and dopamine: Clinical and experimental clues. Curr Opinion in Neurol 2004, 16, 829-835.
Kulkarni SK: Hand book of experimental pharmacology (3rd ed.). Vallabh Prakashan, New Delhi 2004, 24-38.
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