Influence of oxcarbazepine and its combination with SIB-1893 on body temperature in rats
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Department of Pathophysiology, Medical University, Lublin, Poland; Department of Physiopathology, Institute of Agricultural Medicine, Lublin, Poland
Department of Pathophysiology, Medical University, Lublin, Poland
Corresponding author
Jarogniew J. Łuszczki   

Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland.
J Pre Clin Clin Res. 2008;2(1):31-34
The aim of the study was to determine the effects of oxcarbazepine (OXC – a newer antiepileptic drug) administered alone and in combination with SIB-1893 (a selective non-competitive metabotropic glutamate subtype 5 [mGlu5] receptor antagonist) on body temperature in freely moving rats. Temperature was monitored using programmed microchips, implanted subcutaneously in Wistar rats, at several time intervals: 0, 5, 10, 20, 30, 45, 60, 90, 120 and 180 min. after intraperitoneal administration of OXC, SIB-1893, and their combination. Statistical evaluation of data with two-way ANOVA with repeated measure on time revealed that SIB-1893 at a dose of 30 mg/kg significantly decreased the body temperature in rats at times ranging from 90-180 min. after drug administration. In contrast, OXC at a dose of 5 mg/kg, administered alone and in combination with SIB-1893 (30 mg/kg), did not significantly alter the body temperature in freely moving rats. Based on this pre-clinical study, one can conclude that OXC administered alone and in combination with SIB-1893 have no effect on body temperature in rats up to 180 min. after intraperitoneal administration of the drugs.
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