Effect of topiramate and its combination with SIB-1893 on body temperature in rats
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Department of Pathophysiology, Medical University, Lublin, Poland; Department of Physiopathology, Institute of Agricultural Medicine, Lublin, Poland
Department of Experimental and Clinical Pharmacology, Medical University, Lublin, Poland
Corresponding author
Jarogniew J. Łuszczki   

Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland.
J Pre Clin Clin Res. 2009;3(2):114-117
This study was aimed at determining the effects of topiramate (TPM – a second-generation antiepileptic drug) administered alone and in combination with SIB-1893 (a selective non-competitive metabotropic glutamate subtype 5 [mGlu[sub]5[/sub]] receptor antagonist) on body temperature in freely moving rats. Temperature was monitored using programmed microchips, implanted subcutaneously in Wistar rats, at several time intervals: 0, 5, 10, 20, 30, 45, 60, 90, 120, 180, and 240 min after intraperitoneal administration of TPM, SIB-1893, and their combination. Statistical evaluation of data with two-way ANOVA with repeated measures of time revealed that SIB-1893 at a dose of 30 mg/kg, significantly decreased the body temperature in rats, at times ranging from 90-240 min after drug administration. In contrast, TPM at doses of 5 and 10 mg/kg, administered alone and TPM (10 mg/kg) in combination with SIB-1893 (30 mg/kg), did not significantly alter the body temperature in freely moving rats. Based on this preclinical study, one can conclude that TPM administered alone and in combination with SIB-1893 had no effect on body temperature in rats up to 240 min after intraperitoneal administration of the drugs.
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