Effect of topiramate and its combination with SIB-1893 on body temperature in rats
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Department of Pathophysiology, Medical University, Lublin, Poland; Department of Physiopathology, Institute of Agricultural Medicine, Lublin, Poland
Department of Experimental and Clinical Pharmacology, Medical University, Lublin, Poland
Jarogniew J. Łuszczki   

Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland.
J Pre Clin Clin Res. 2009;3(2):114–117
This study was aimed at determining the effects of topiramate (TPM – a second-generation antiepileptic drug) administered alone and in combination with SIB-1893 (a selective non-competitive metabotropic glutamate subtype 5 [mGlu[sub]5[/sub]] receptor antagonist) on body temperature in freely moving rats. Temperature was monitored using programmed microchips, implanted subcutaneously in Wistar rats, at several time intervals: 0, 5, 10, 20, 30, 45, 60, 90, 120, 180, and 240 min after intraperitoneal administration of TPM, SIB-1893, and their combination. Statistical evaluation of data with two-way ANOVA with repeated measures of time revealed that SIB-1893 at a dose of 30 mg/kg, significantly decreased the body temperature in rats, at times ranging from 90-240 min after drug administration. In contrast, TPM at doses of 5 and 10 mg/kg, administered alone and TPM (10 mg/kg) in combination with SIB-1893 (30 mg/kg), did not significantly alter the body temperature in freely moving rats. Based on this preclinical study, one can conclude that TPM administered alone and in combination with SIB-1893 had no effect on body temperature in rats up to 240 min after intraperitoneal administration of the drugs.
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