The effects of long-term administration of a standardised extract of Curcuma longa on the explorative activity in aged 24-month-old male Wistar rats were estimated in a hole-board test. The animals received the extract orally
for two months in rodent chow at doses of 10 and 50 mg/kg/day. The correlations between concentration of some neurotransmitters and amino acids in selected brain regions, as well as the level of corticosterone in plasma (described previously), and the parameters of exploration were calculated. The antioxidant processes (GSH, GST, CAT and MDA
levels) in heart and skeletal muscles were also investigated. The results suggested that the explorative activity of plant extract-treated rats was enhanced; however, no correlations between brain neurotransmitter concentration or plasma corticosterone level and the parameters of explorative activity were observed. In biochemical investigation, chronic C. longa extract administration influenced antioxidant processes (CAT, GST and MDA levels) in skeletal muscles of aged rats, but not in the heart muscle.
REFERENCES(84)
1.
Pyrzanowska J, Piechal A, Blecharz-Klin K, Lehner M, Skorzewska A, Turzyńska D, Sobolewska A, Plaznik A, Widy-Tyszkiewicz E: The influence of the long-term administration of Curcuma longa extract on learning and spatial memory as well as the concentration of brain neurotransmitters and level of plasma corticosterone in aged rats. Pharmacol Biochem Beh 2010, 95, 351-358.
Hiserodt R, Hartman TG, Ho CT, Rosen RT: Characterization of powdered turmeric by liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry. J Chromatogr A 1996, 740, 51-63.
Quiles JL, Mesa MD, Ramirez-Tortosa CL, Aguilera CM, Battino M, Gil A, Ramirez-Tortosa MC: Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arterioscler Thromb Vasc Biol 2002, 22, 1225-1231.
Hong J, Bose M, Ju J, Ryu JH, Chen XC, Sang S, Lee MJ, Yang CS: Modulation of arachidonic acid metabolism by curcumin and related b-diketone derivatives: effects on cytosolic phospholipase A2, cyclooxygenases and 5-lipooxygenase. Carcinogenesis 2004, 25, 1671-1679.
Frautschy SA, Hu W, Kim P, Miller SA, Chu T, Harris-White ME, Cole GM: Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol Aging 2001, 22, 993- 1005.
Xu Y, Ku B, Cui L, Li X, Barish PA, Foster TC, Ogle WO: Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain Res 2007, 1162, 9-18.
Sandur SK, Ichikawa H, Pandey MK, Kunnumakkara AB, Sung B, Sethi G, Aggarwal BB: Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects ofcurcumin (diferuloylmethane). Free Radic Biol Med 2007, 43, 568-580.
Daniel S, Limson JL, Dairam A, Watkins GM, Daya S: Through metal binding, curcumin protects against lead- and cadmium- induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain. J Inorg Biochem 2004, 98, 266-275.
Ghoneim AI, Abdel-Naim AB, Khalifa AE, El-Denshary ES: Protective effects of curcumin against ischemia/reperfusion insult in rat forebrain. Pharmacol Res 2002, 46, 273-279.
Zhao J, Zhao Y, Zheng W, Lu Y, Feng G, Yu S: Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats. Brain Res 2008, 1229, 224-232.
Xia X, Cheng G, Pan Y, Xia ZH, Kong LD: Behavioral, neurochemical and neuroendocrine effects of ethanolic extract from Curcuma longa L. in the mouse forced swimming test. J Ethnopharmacol 2007, 110, 356-363.
Bishnoi M, Chopra K, Kulkarni SK: Protective effect of Curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes in rat brain. Pharmacol Biochem Behav 2008, 88, 511-522.
Kulkarni SK, Bhutani MK, Bishnoi M: Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psychopharmacology 2008, 201, 435-442.
Bhutani MK, Bishnoi M, Kulkarni SK: Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes. Pharmacol Biochem Behav 2009, 92, 39-43.
Li YC, Wang FM, Pan Y, Qiang LQ, Cheng G, Zhang WY, Kong LD: Antidepressant-like effects of curcumin on serotonergic receptorcoupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33, 435-449.
Sedlak J, Lindsay RH: Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s Reagent. Anal Biochem 1968, 25, 192-205.
Takeda H, Tsuji M, Matsumiya: Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice. Eur J Pharmacol 1998, 350, 21-29.
Brown GR, Nemes C: The exploratory behaviour of rats in the holeboard apparatus: Is head-dipping a valid measure of neophilia? Behav Procc 2008, 78, 442-448.
Marin MT, Cruz FC, Planeta CS: Chronic restraint or variable stresses differently affect the behavior, corticosterone secretion and body weight in rats. Physiol Behav 2007, 90, 29-35.
Xu Y, Ku BS, Tie L, Yao H, Jiang W, Ma X, Li X: Curcumin reverses the effect of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Brain Res 2006, 1122, 56-64.
Xu Y, Lin D, Li S, Li G, Shyamala SG, Barish PA, Vernon MM, Pan J, Ogle W: Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress. Neuropharmacology 2009, 57, 463-471.
Kumar A, Dogra S, Prakash A: Protective effects of curcumin (Curcuma longa), against aluminium toxicity: Possible behavioral and biochemical alterations in rats. Behav Brain Res 2009, 205, 384-390.
Awasthi H, Tota S, Hanif K, Nath C, Shukla R: Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow. Life Sci 2010, 86, 87-94.
Takeda H, Tsuji M, Ikoshi H, Yamada T, Masuya J, Iimori M, Matsumiya T: Effects of a 5-HT7 receptor antagonist DR4004 on the exploratory behavior in a novel environment and on brain monoamine dynamics in mice. Eur J Pharmacol 2005, 518, 30-39.
Xu Y, Ku BS, Yao HY, Lin YH, Ma X, Zhang YH, Li XJ: Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Pharmacol Biochem Behav 2005, 82, 200- 206.
Nishimura A, Ueda S, Takeuchi Y, Sawada T, Kawata M: Age-related, decrease of serotonergic fibres and S-100 beta immunoreactivity in the rat dentate gyrus. Neuroreport 1995, 6, 1445-1448.
Wang R, Xu Y, Wu HL, Li YB, Li YH, Guo JB, Li XJ: The antidepressant effect of curcumin in the forced swimming test involve 5-HT1 and 5- HT-2 receptors. Eur J Pharmacol 2008, 578, 43-50.
Tsuji M, Takeda H, Matsumiya T: Different effects of 5-HT1A receptor agonists and benzodiazepine anxiolytics on the emotional state of naïve and stressed mice: a study using the hole-board test. Psychopharmacology (Berl) 2000, 152, 157-166.
Motterlini R, Foresti R, Bassi R, Green CJ: Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med 2000, 28, 1303-1312.
Awasthi S, Pandya U, Singhal SS, Lin JT, Thiviyanathan V, Seifert Jr WE, Awasthi YC, Ansari GA: Curcumin-glutahione interactions and the role of human glutathione S-transferase P1-1. Chem Biol Interactions 2000, 128, 19-38.
Balogun E, Hogue M, Gong P, Kileen P, Green CJ, Foresti R, Alam J, Motterlini R: Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. J Biochem 2003, 371, 887-895.
Iqbal M, Sharma SD, Okazaki Y, Fujisawa M, Okada S: Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacol Toxicol 2003, 92, 33-38.
Rushworth SA, Ogborne RM, Charalambos CA, O’Connell MA: Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes. Biochem Biophys Res Commun 2006, 341, 1007-1016.
Wei QY, Chen WF, Zhou B, Yang L, Liu ZL: Inhibition of lipid peroxidation and protein oxidation in rat liver mitochondria by curcumin and its analogues. Biochim Biophys Acta 2006, 1760, 70- 77.
Bhaumik S, Anjum R, Rangaraj N, Pardhasaradhi BV, Khar A: Curcumin mediated apoptosis in AK-5 tumor cells involves the production of reactive oxygen intermediates. FEBS Lett 1999, 456, 311-314.
Fang J, Lu J, Holmgren A: Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity. J Biol Chem 2005, 280, 25284-25290.
Li H, van Berlo D, Shi T, Speit G, Knaapen AM, Borm PJ, Albrecht C, Schins RP: Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line. Toxicol Appl Pharmacol 2008, 227, 115-124.
Chen J, Wanming D, Zhang D, Liu Q, Kang J: Water-soluble antioxidants improve the antioxidant and anticancer activity of low concentrations of curcumin in human leukemia cells. Pharmazie 2005, 60, 57-61.
Kunwar A, Sandur SK, Krishna M, Priyadarsini KI: Curcumin mediates time and concentration dependent regulation of redox homeostasis leading to cytotoxicity in macrophage cells. Eur J Pharm 2009, 611, 8-16.
Gutowicz M, Chołojczyk M, Pyrzanowska J, Widy-Tyszkiewicz E, Barańczyk-Kuźma A: Wpływ kurkuminy na detoksykacyjne i antyoksydacyjne mechanizmy w wątrobie szczurow podczas starzenia (in Polish). Effect of curcumin on detoxicative and anti-oxidative mechanisms in rat’s liver during ageing. Med Wet 2008, 64, 955 957.
Reeta KH, Mehla J, Gupta YK: Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats Brain Res 2009, 1301, 52-60.
Lavoie S, Chen Y, Dalton TP, Gysin R, Cuenod M, Steullet P, Do KQ: Curcumin, quercetin, and tBHQ modulate glutathione levels in mastrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit. J Neurochem 2009, 108, 1410-1422.
El-Demerdash FM, Yousef MI, Radwan FM: Ameliorating effect of curcumin on sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs. Food Chem Toxicol 2009, 47, 249- 254.
Appiah-Opong R, Commandeur JN, Istyastono E, Bogaards JJ, Vermeulen NP: Inhibition of human glutathione S-transferases by curcumin and analogues. Xenobiotica 2009, 39, 302-311.
Ali MS, Mudagal MP, Goli D: Cardioprotective effect of tetrahydrocurcumin and rutin on lipid peroxides and antioxidants in experimentally induced myocardial infarction in rats. Pharmazie 2009, 64, 132-136.
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