RESEARCH PAPER
Isobolographic interaction between AO-294, an enantiomer of losigamone, and valproate in the mouse model of maximal electroshock
 
More details
Hide details
1
Experimental Neuropathophysiology Unit, Department of Pathophysiology, Medical University, Lublin, Poland
 
 
Corresponding author
Kinga Borowicz   

Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland.
 
 
J Pre Clin Clin Res. 2007;1(1):43-44
 
KEYWORDS
ABSTRACT
The objective of the present study was to determine the exact type of interaction between AO-294, the less active enantiomer of a novel antiepileptic drug losigamone and valproate, in the model of maximal electroshock-induced convulsions in mice. Isobolographic analysis of obtained data show that the 2 drugs interact additively. This may suggest that AO-294 may be used in the 2-drug therapy of refractory epilepsy. However, it does not seem to be superior to its maternal antiepileptic, since losigamone (according to previous reports) interacted synergistically with valproate.
REFERENCES (9)
1.
Borowicz KK, Małek R, Kimber-Trojnar Z, Sobieszek G: Isobolographic analysis of the interactions of losigamone, remacemide, zonisamide with conventional antiepileptic drugs in the maximal electroshock test in mice – preliminary report. Neurol Neurochir Pol 2003, 3, 35-36.
 
2.
Bialer M, Johannessen SI, Kupferberg HJ, Levy RH, Loiseau P, Perucca E: Progress report on new antiepileptic drugs: a summary of the 4th Eilat conference (EILAT IV). Epilepsy Res 1999, 34, 1-41.
 
3.
Gąsior M, Ungard JT, Witkin JM: Preclinical evaluation of newly approved and potential antiepileptic drugs against cocaine-induced seizures. J Pharmacol Exp Ther 1999, 290, 1148-1156.
 
4.
Jones FA, Davies JA: The anticonvulsant effects of the enantiomers of losigamone. Br J Pharmacol 1999, 128, 1223-1228.
 
5.
Dimpfel W, Chatterje SS, Noldner M, Ticku MK: Effects of the anticonvulsant losigamone and its isomers on GABA-receptor system. Epilepsia 1995, 36, 983-989.
 
6.
Litchfield JT, Wilcoxon F: A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 1949, 96, 99–113.
 
7.
Loewe S: The problem of synergism and antagonism of combined drugs. Arzneimittelforschung 1953, 3, 285-290.
 
8.
Łuszczki JJ, Czuczwar SJ: Isobolographic characterization of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. Naunyn Schmiedeberg’s Arch Pharmacol 2005, 372, 41-54.
 
9.
Tallarida RJ, Stone DJ, Raffa RB: Efficient designs for studying synergistic drug combinations. Life Sci 1997, 61, 417–425.
 
eISSN:1898-7516
ISSN:1898-2395
Journals System - logo
Scroll to top