Anticonvulsant activity of conventional antiepileptic drugs unaltered by vinpocetine in mouse model of epilepsy
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Experimental Neuropathophysiology Unit, Department of Pathophysiology, Lublin
Department of Pharmacology and Clinical Pharmacology, Medical University, Lublin, Poland
J Pre Clin Clin Res. 2007;1(1):45-46
The objective of the study was to determine the effect of combined treatment with vinpocetine (VIN) (a commonly used nootropic drug blocking voltage-gated Na+ channels) and conventional antiepileptic drugs: carbamazepine (CBZ), valproate (VPA), phenobarbital (PB), and phenytoin (PHT) against maximal electroshock-induced convulsions in mice. Vinpocetine (up to 30 mg/kg) did not present either its own anticonvulsant action or have any effect on the protective effect of antiepileptic drugs. This may indicate that not all Na+ channel inhibitors are effective against electroconvulsions. On the other hand, concomitant treatment with vinpocetine and antiepileptics should not require any dose corrections in epileptic patients.
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