Effect of three glutamatergic metabotropic receptor ligands on electrically-induced seizures in mice
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Experimental Neuropathophysiology Unit, Department of Pathophysiology, Medical University, Lublin, Poland
Corresponding author
Kinga Borowicz   

Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland.
J Pre Clin Clin Res. 2007;1(1):47-48
The objective of this study was to determine whether the effect of 3 agonists of glutamatergic metabotropic receptors (mGluRs): ACPT, DCPG, MTPG. ACPT and DCPG (agonists of mGluR III receptors) administered at the dose of 20 mg/kg increased the electroconvulsive threshold in mice. In contrast, MTPG, an agonist of mGluR II and mGluR III receptors, applied at the same dose (20 mg/kg) significantly decreased the threshold, presenting proconvulsant action. This surprising effect may be due to agonistic properties of MTPG towards mGluR II receptors.
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