Isobolographic interaction between AO-294, an enantiomer of losigamone, and phenobarbital in the mouse model of maximal electroshock
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Experimental Neuropathophysiology Unit, Department of Pathophysiology, Medical University, Lublin, Poland
Corresponding author
Kinga Borowicz   

Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland.
J Pre Clin Clin Res. 2007;1(1):41-42
The objective of the present study was to determine the exact type of interaction between AO-294, the less active enantiomer of a novel antiepileptic drug losigamone and phenobarbital in the model of maximal electroshock-induced convulsions in mice. Isobolographic analysis of obtained data show that the 2 drugs interact additively when administered in proportions of 1:3 and 1:1. Antagonism was found at the dose ratio of 3:1. This may suggest that AO-294 is not a good candidate for 2-drug therapy with phenobarbital, especially when administered at relatively high doses.
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