Influence of coffee drinking on epilepsy control
More details
Hide details
Department of Neurological Diseases, Institute of Medical Education, Świętokrzyska Academy, Kielce, Poland; Department of Neurology, Neuropsychiatric Hospital, Kielce, Poland
Corresponding author
Barbara Błaszczyk   

Department of Neurology, WSZON, Grunwaldzka 47, 25-730 Kielce, Poland
J Pre Clin Clin Res. 2007;1(1):98-99
Caffeine is a global stimulant the increased intake of which leads to a lowering of the seizure threshold, which may result in reduced control of epilepsy. Two cases are reported: a male with well-controlled epilepsy, and a female with drug-resistant, moderately-controlled epilepsy. In both patients, temporary excessive coffee consumption led to increased seizure frequency, and withdrawal of coffee from the diet resulted in a return to the previous status.
Schmidt D, Loscher W: Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms. Epilepsia 2005, 46, 858-877.
Gąsior M, Borowicz K, Buszewicz G, Kleinrok Z, Czuczwar SJ: Anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice during chronic treatment with caffeine and caffeine discontinuation. Epilepsia 1996, 37, 262-268.
Kaufman KR, Sachdeo RC: Caffeinated beverages and decreased seizure control. Seizure 2003, 12, 519-521.
Bonilha L, Li M: Heavy coffee drinking and epilepsy. Seizure 2004, 13, 284-285.
Zagnoni PG, Albano C: Psychostimulants and epilepsy. Epilepsia 2002, 43 (2), 28-31.
Spinella M: Herbal medicines and epilepsy: The potential for benefit and adverse effects. Epilep Behav 2001, 2, 524-532.
Chu N-S: Caffeine- and aminophylline-induced seizures. Epilepsia 1981, 22, 85-94.
Czuczwar SJ, Kleinrok Z: Modulation of the protective efficacy of common antiepileptic drugs by xanthine derivatives: Implications for the clinical use of xanthines in epileptic patients. Pharmacol Res 1990, 22, 661-665.
Czuczwar SJ, Gąsior M, Janusz W, Szczepanik B, Włodarczyk D, Kleinrok Z: Influence of different methylxanthines on the anticonvulsant action of common antiepileptic drugs in mice. Epilepsia 1990, 31, 318-323.
Gąsior M, Borowicz K, Kleinrok Z, Czuczwar SJ: Chronic caffeine and the anticonvulsant potency of antiepileptic drugs against maximal electroshock. Pharmacol Biochem Behav 1996, 54, 639-644.
Vaz J, Kulkarni C, David J, Joseph T: Influence of caffeine on pharmacokinetic profile of sodium valproate and carbamazepine in normal human volunteers. Indian J Exp Biol 1998, 36, 112-114.
Wietholtz H, Zysset T, Kreiten K, Kohl D, Buchsel R, Matern S: Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism. Eur J Clin Pharmacol 1989, 36, 401-406.
Journals System - logo
Scroll to top