The growing popularity of Internet trends promoting poisonous mushrooms as ‘natural therapies’ poses a risk for public health. Amanita phalloides is a highly hepatotoxic species that can cause acute liver failure, while neurological complications are rare. The case is reported of a 57-year-old woman with depression, admitted after a generalized tonic-clonic seizure. She had ingested dried Amanita phalloides for three weeks, and the day before admission an additional powdered dose, which caused diarrhea, loss of consciousness, and convulsions. Believing in the therapeutic effect, she had also placed mushroom fragments in the umbilical region. Laboratory tests showed elevated creatine kinase and mildly increased aminotransferases; EEG revealed temporo-parieto-occipital abnormalities. Supportive treatment led to clinical improvement. The case highlights the risks of Internet-based pseudotherapies, and the importance of thorough history-taking.