Introduction and objective:
Periodontitis is a multifactorial inflammatory disease triggered by the dysbiosis of subgingival microbial biofilm and fuelled by host immune response. Periodontal inflammation may affect other systems and organs. Systemic inflammation is also a main characteristic of severe forms of Corona-Virus-Disease-2019 (COVID-19). Some genetic/ environmental factors in periodontitis patients might implicate the course of COVID-19, thus, the aim of the study was to analyse the association of periodontitis with COVID-19 complications.

Review methods:
Literature available on 13 August 2022 was searched by using the PubMed, Web of Science and Google Scholar databases. Articles were selected that contained the key words: COVID-19, SARS-CoV-2, periodontitis, oral manifestation.

Brief description of the state of knowledge:
From the initial serach, 26 articles were retrieved for final analysis. Available data have shown that periodontitis may be a predisposing factor for the development of severe COVID-19. Periodontitis was associated with increased rates of hospitalization, assisted ventilation and death due to COVID-19 complications. Similar inflammatory pathways are activated in COVID-19 and periodontitis, and periodontal pathogens may contribute to a more severe course of COVID-19.

Since some evidence confirms a relationship between periodontitis and severity of COVID-19, it is essential to maintain periodontal health and good oral hygiene as an important measure for the prevention and management of COVID-19 and its complications.

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