Therapeutic significance of curcumin and its role in cancer treatment
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Military Institute of Medicine, Department of Maxillofacial Surgery, Warsaw, Poland; Department of Periodontology, Medical University of Lublin, Poland
Department of Periodontology, Medical University of Lublin, Poland
Department of Prosthodontics, Medical University of Lublin, Poland
J Pre Clin Clin Res. 2012;6(2):73–76
Curcumin has been used for thousands of years in traditional Indian medicine. Recent in vitro and in vivo animal studies have demonstrated its numerous properties such as: anti-inflammatory, antiviral, antibacterial, antimalarial, antifungal, anaesthetic, chemopreventive, and antineoplastic. Thus, on account of the wide spectrum of properties, curcumin can contribute to modern medicine not only in the treatment of cancer or neurodegenerative diseases, but also in allergies, diabetics, joint diseases, Alzheimer’s, and a number of other chronic diseases. Therefore, most often it has been called the ‘spice for life’.

To present a review of the literature on the potential usage of curcumin in the treatment of diseases of the oral cavity and other dental problems. Furthermore, it indicates the expectations of researchers towards the compound and emphasises its importance in prophylactics.

It is likely that a thorough examination of curcumin and its role in the treatment of cancer, neurodegenerative diseases and allergies, may help to introduce new educational projects and preventive programmes for public health care. The introduction of prophylactics and early treatment could prevent possible complications and advanced stages of the diseases from occurring. On account of the extensive therapeutic properties, curcumin may be used by physicians of various specialities for health promotion. Thus, since health is the key to the development of every civilization, environmental implementation of the new prophylactic projects will improve the quality of life. Nevertheless, the problem of curcumin being rapidly metabolised along with the difficulties with reaching therapeutic levels without side-effects remains significant.

Curcumin may be the new hope for reducing incidence of cancer.

.Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007; 595: 1-75.
Wolanin K, Piwocka K. Kurkumina – od medycyny naturalnej do kliniki (Curcumin – from traditional medicine to the clinic). Kosmos. 2008; 1-2: 53-65 (in Polish).
Chaturvedi TP. Uses of turmeric in dentistry: An update. Indian J Dent Res 2009; 20: 107-109.
Lopez-Lazaro M. Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent. Mol Nutr Food Res. 2008; 52: S103-27.
Syng-Ai C, Kumari AL, Khar A. Effect of curcumin on normal and tumor cells: role of glutathione and bcl-2. Mol Cancer Ther. 2004; 3: 1101-8.
Lopez-Lazaro M, Willmore E, Jobson A et al. Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells. J Nat Prod. 2007; 70: 1884-8.
Cheng AL, Hsu CH, Lin JK, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 2001; 21: 2895-2900.
Lim G P, Chu T, Yang F, et al. The curry spice curcumin reduces oxidative damage and amyloid pathology in an alzheimer transgenic mouse. J Neurosci. 2001; 21: 8370-8377.
Ringman J M, Frautschy S A, et al. A potential role of the curry spice curcumin in Alzheimer’s disease. Curr Alzheimer Res. 2005; 2: 131-136.
Rajasekaran S A. Therapeutic potential of curcumin in gastrointestinal Diseases. World J Gastrointest Pathophysiol. 2011; 2: 1-14.
Syng-Ai C, Kumari AL, Khar A. Effect of curcumin on normal and tumor cells: role of glutathione and bcl-2. Mol Cancer Ther. 2004; 3: 1101-1108.
Shoba G, Joy D, Joseph T, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998; 64: 353-356.
Li L, Braiteh FS, Kurzrock R. Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer 2005; 104: 1322-1331.
Bisht S, Feldmann G, Soni S, et al. Polymeric nanoparticle-encapsulated curcumin (“nanocurcumin”): a novel strategy for human cancer therapy. J Nanobiotechnol. 2007; 5: 3.
Kurien BT, Scofield RH. Oral administration of heat-solubilized curcumin for potentially increasing curcumin bioavailability in experimental animals. Int J Cancer. 2009; 125: 1992-1993.
Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Molecular Pharm. 2007; 4: 807-818.
Gandini S, Negri E, Boffetta P, Vecchia CL, Boyle P. Mouthwash and Oral Cancer Risk Quantitative Meta-analysis of Epidemiologic Studies. Ann Agric Environ Med. 2012; 19(2): 173-180.
Zebib B, Mouloungui Z, Noirot V. Stabilization of Curcumin by Complexation with Divalent Cations in Glycerol/Water System. Bioinorg Chem Appl. 2010; 2010: doi:10.1155/2010/292760.
Li L, Braiteh FS, Kurzrock R. Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer. 2005; 104: 1322-1331.
Sharma RA, Gescher AJ, Steward WP. Curcumin: the story so far. Eur J Cancer. 2005; 41: 1955-1968.
Rai B, Kaur J, Jacobs R, et al. Possible action mechanism for curcumin in pre-cancerous lesions based on serum and salivary markers of oxidative stress. J Oral Sci. 2010; 52(2): 251-6.
Pyrzanowska J, Piechal A, Blecharz-Klin K, et al. Influence of long-term administration of Curcuma longa extract on explorative activity in aged rats. J Pre-Clin. Clin Res. 2010; 4(2):134-140.
Guimaraes M R, Coimbra L S, de Aquino S G, et al. Potent antiinflammatory effects of systemically administered curcumin modulate periodontal disease in vivo. J Periodont Res. 2011; 46: 269-279.
O’Sullivan-Coyne G, O’Sullivan G C, O’Donovan T R, et al. Curcumin induces apoptosis-independent death in oesophageal cancer cells. Br J Cancer. 2009; 101(9): 1585-1595.
Piotrowska A, Iżykowska I, Podhorska-Okołów M, et al. Budowa białek z rodziny NF-kB i ich rola w procesie apoptozy (The structure of NF-kB family proteins and their role in apoptosis). Postepy Hig Med Dosw. 2008; 62: 64-74 (in Polish).
Milacic V, Banerjee S, Landis-Piwowar K R et al. Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo. Cancer Res. 2008; 68(18): 7283-7292.
Park J, Conteas CN. Anti-carcinogenic properties of curcumin on colorectal cancer. World J Gastrointest Oncol. 2010; 2: 169-176.
Kim K, Lee C. Curcumin Induces Downregulation of E2F4 Expression and Apoptotic Cell Death in HCT116 Human Colon Cancer Cells; Involvement of Reactive Oxygen Species. Korean J Physiol Pharmacol. 2010; 14(6): 391-397.
Yingjie Yu, Shailender S Kanwar, Bhaumik B Patel, et al. Elimination of Colon Cancer Stem-Like Cells by the Combination of Curcumin and FOLFOX. Transl Oncol. 2009; 2(4): 321-328.
Garcea G, Berry DP, Jones DJ, et al. Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiol Biomarkers Prev. 2005; 14: 120-125.
Rafiee P, Binion DG, Wellner M, et al. Modulatory effect of curcumin on survival of irradiated human intestinal microvascular endothelial cells: role of Akt/mTOR and NF-{kappa}B. Am J Physiol Gastrointest Liver Physiol. 2010; 298(6): G865-77.
Bharat B, Harikumar K B. Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases. Int J Biochem Cell Biol. 2009; 41(1): 40-59.
Kozuch P L, Hanauer S B. Treatment of inflammatory bowel disease: A review of medical therapy. World J Gastroenterol. 2008; 14(3): 354-377.
Sahu R P, Batra S, Srivastava S K. Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells. Br J Cancer. 2009; 100(9): 1425-1433.
Subramaniam D, Ramalingam S, Linehan D C et al. RNA Binding Protein CUGBP2/CELF2 Mediates Curcumin-Induced Mitotic Catastrophe of Pancreatic Cancer Cells. PLoS One 2011; 6(2): e16958.
Friedman L, Lin L, Ball S, et al. Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells. Anticancer Drugs. 2009 July; 20(6): 444-449.
Yoysungnoen P, Wirachwong P, Bhattarakosol P, et al. Antiangiogenic activity of curcumin in hepatocellular carcinoma cells implanted nude mice. Clin Hemorheol Microcirc. 2005; 33: 127-135.
Chuang SE, Kuo ML, Hsu CH et al. Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. Carcinogenesis 2000; 21: 331-335.
Hamaguchi T, Ono K, Yamada M. REVIEW: Curcumin and Alzheimer’s disease. CNS Neurosci Ther 2010: 16 (5): 285-97.
Mathew A, Fukuda T, Nagaoka Y, Hasumura T, Morimoto H, et al. Curcumin Loaded-PLGA Nanoparticles Conjugated with Tet-1 Peptide for Potential Use in Alzheimer’s Disease. PLoS One, 2012; 7 (3): e32616.
Ye F, Zhang GH, Guan BX, Xu XC. Suppression of esophageal cancer cell growth using curcumin, (-)-epigallocatechin-3-gallate and lovastatin. World J Gastroenterol. 2012; 18(2): 126-35.
Subramaniam D, Ponnurangam S, Ramamoorthy P, Standing D, Battafarano RJ, et al. Curcumin Induces Cell Death in Esophageal Cancer Cells through Modulating Notch Signaling. PLoS One, 2012;7(2): e30590.
Babaei E, Sadeghizadeh M, Hassan ZM, Feizi MA, Najafi F, Hashemi SM. Dendrosomal curcumin significantly suppresses cancer cell proliferation in vitro and in vivo. Int Immunopharmacol. 2012; 12 (1): 226-34.
Lai HW, Chien SY, Kuo SJ, Tseng LM, Lin HY, Chi CW, Chen DR. The Potential Utility of Curcumin in the Treatment of HER-2-Overexpressed Breast Cancer: An In Vitro and In Vivo Comparison Study with Herceptin. Evid Based Complement Alternat Med. 2012; 2012: 486568.
Bojar I, Bilinski P, Boyle P, et. al. Prevention of female reproductive system cancer among rural and urban Polish pregnant women. Ann Agric Environ Med. 2011; 18(1): 183-188.