The influence of cyclosporine A, cyclothiazide and luzindole on the electroconvulsive threshold in mice
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Experimental Neuropathophysiology Unit, Department of Pathophysiology, Medical University, Lublin, Poland
Kinga Borowicz   

Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland.
J Pre Clin Clin Res. 2007;1(1):49–50
The objective of this study was to determine the effect of cyclosporine A (CSA) (a widely used immunosuppressant drug), cyclothiazide (CTZ) (an inhibitor of desensitization of glutamatergic AMPA receptors) and luzindole (LZ) (an antagonist of melatonin MT2 receptors) on the threshold in the electroconvulsive test in mice. Cyclosporine A and luzindole (up to 50 mg/kg) did not affect this parameter. Cyclothiazide (5-20 mg/kg) dose-dependently lowered the threshold. Our results suggest that cyclothiazide should be avoided in epileptic patients. In contrast to chemically-evoked convulsions, cyclosporine A does not seem to affect electrically-induced convulsions. Finally, the protective action of melatonin is probably not mediated via MT2 receptors.
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