RESEARCH PAPER
The influence of cyclosporine A, cyclothiazide and luzindole on the electroconvulsive threshold in mice
| 1 | Experimental Neuropathophysiology Unit, Department of Pathophysiology, Medical University, Lublin, Poland |
CORRESPONDING AUTHOR
Kinga Borowicz
Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland.
Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland.
J Pre Clin Clin Res. 2007;1(1):49–50
KEYWORDS
ABSTRACT
The objective of this study was to determine the effect of cyclosporine A (CSA) (a widely used immunosuppressant drug), cyclothiazide (CTZ) (an inhibitor of desensitization of glutamatergic AMPA receptors) and luzindole (LZ) (an antagonist of melatonin MT2 receptors) on the threshold in the electroconvulsive test in mice. Cyclosporine A and luzindole (up to 50 mg/kg) did not affect this parameter. Cyclothiazide (5-20 mg/kg) dose-dependently lowered the threshold. Our results suggest that cyclothiazide should be avoided in epileptic patients. In contrast to chemically-evoked convulsions, cyclosporine A does not seem to affect electrically-induced convulsions. Finally, the protective action of melatonin is probably not mediated via MT2 receptors.
REFERENCES (10)
1.
Pierzchała E: Cyklosporyna A – znaczenie i zastosowanie w dermatologii. Derm Klin 2004, 6, 18-22.
2.
Shuto H, Kataoka Y, Kananya A, Matsanunaga K, Sueyasu M, Oishi R: Enhancement of serotoninergic neural activity contributes to cyclosporine-induced tremors in mice. Eur J Pharmacol 1998, 341, 33-37.
3.
Sun Y, Olson R, Horning M, Armstrong N, Mayer M, Gouaux E: Mechanism of glutamate receptor desensitization. Nature 2002, 417, 245-253.
4.
Hogan M, El-Sherif Y, Wieraszko A: The modulation of neuronal activity by melatonin: in vitro studies on mouse hippocampal slices. J Pineal Res 2001, 30, 87-96.
5.
Litchfield JT, Wilcoxon F: A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 1949, 96, 99-113.
6.
Asanuma M, Nishibayashi S, Kondo Y, Iwata E, Tsuda M, Ogawa E: Effects of single cyclosporine A pretreatment on pentylenetetrazolinduced convulsion and on TRE-binding activity in the rat brain. Mol Brain Res 1995, 33, 29-36.
7.
Deierhoi MH, Kalayoglu M, Sollinger HW, Belzer FO: Cyclosporine neurotoxicity in liver transplant recipients: report of three cases. Transplant Proc 1988, 20, 116-118.
8.
Borowicz KK, Łuszczki J, Szadkowski M, Kleinrok Z, Czuczwar SJ: Influence of LY 300164, an antagonist of AMPA/kainate receptors, on the anticonvulsant activity of clonazepam. Eur J Pharmacol 1999, 380, 67-72.
9.
Sandyk R, Tsagas N, Anninos PA: Melatonin as a proconvulsive hormone in humans. Int J Neurosci 1992, 63, 125-135.
10.
Borowicz KK, Kamiński R, Gąsior M, Kleinrok Z, Czuczwar SJ: Influence of melatonin upon the protective action of conventional antiepileptic drugs against maximal electroshock in mice. Eur Neuropharmacol 1999, 9, 185-190.
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