CASE REPORT
Successful surgical treatment in a patient with a giant pituitary macroadenoma accompanied by obstructive hydrocephalus
| 1 | Chair and Department of Neurology, Medical University, Lublin, Poland |
| 2 | Student Research Group of Neurology, Medical University, Lublin, Poland |
CORRESPONDING AUTHOR
J Pre Clin Clin Res. 2019;13(3):130–133
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Pituitary adenomas are the most common tumours of the sella turcica region, representing 10–15% of all primary intracranial tumors. They can be divided into macroadenomas and microadenomas, and also into non-active adenomas and hormonally active tumors. Although they are usually limited to the sellar region, larger ones can cause its destruction, infiltrate or compress adjacent structures, such as the optic chiasm, and therefore lead to a more aggressive clinical course. The case report is presented of a 66-year-old female patient with a giant pituitary tumour accompanied by obstructive hydrocephalus, in which the tumour was big enough to cause severe neurological symptoms and required urgent surgical intervention.
Objective:
The aim of the study was to describe the correct management in the case of giant pituitary tumours which could lead to rapid deterioration of the general and neurological condition of the patient.
Pituitary adenomas are the most common tumours of the sella turcica region, representing 10–15% of all primary intracranial tumors. They can be divided into macroadenomas and microadenomas, and also into non-active adenomas and hormonally active tumors. Although they are usually limited to the sellar region, larger ones can cause its destruction, infiltrate or compress adjacent structures, such as the optic chiasm, and therefore lead to a more aggressive clinical course. The case report is presented of a 66-year-old female patient with a giant pituitary tumour accompanied by obstructive hydrocephalus, in which the tumour was big enough to cause severe neurological symptoms and required urgent surgical intervention.
Objective:
The aim of the study was to describe the correct management in the case of giant pituitary tumours which could lead to rapid deterioration of the general and neurological condition of the patient.
REFERENCES (12)
1.
Beatriz M, Lopes S. The 2017 World Health Organization classification of tumors of the pituitary gland: a summary. Acta Neuropathol. 2017; 134(4): 521–535. https://doi.org/10.1007/s00401....
2.
Dekkers OM, Hammer S, de Keizer RJW, Roelfsema F, Schutte PJ, Smit JWA. The natural course of non-functioning pituitary macroadenomas. Eur J Endocrinol. 2007; 156: 217–224. https://doi.org/10.1530/eje.1.....
3.
Manojlovic-Gacic E, Engström BE, Casar-Borota O. Histopathological classification of non-functioning pituitary neuroendocrine tumors. Pituitary. 2018; 21(2): 119–129. https://doi.org/10.1007/s11102... 0855-1.
4.
Sadik ZHA, Voormolen EHJ, Depauw PRAM, Burhani B, Nieuwlaat WA, Verheul J, et al. Treatment of Nonfunctional Pituitary Adenoma Postoperative Remnants: Adjuvant or Delayed Gamma Knife Radiosurgery? World Neurosurgery 2017; 100: 361–368. https://doi. org/10.1016/j.wneu.2017.01.028.
5.
Ferrante E, Ferraroni M, Castrignano T, Menticatti L, Anagni M, Reimondo G, et al. Non-functioning pituitary adenoma database: a useful resource to improve the clinical management of pituitary tumours. Eur J Endocrinol. 2006; 155(6): 823–829.
6.
Honegger J, Ernemann U, Psaras T, Will B. Objective criteria for successful transsphenoidal removal of suprasellar nonfunctioning pituitary adenomas. A prospective study. Acta Neurochir. 2007; 149(1): 21–9.
7.
Little AS, Chicoine MR, Kelly DF, Sarris CE, Mooney MA, White WL. Evaluation of Surgical Resection Goal and Its Relationship to Extent of Resection and Patient Outcomes in a Multicenter Prospective Study of Patients With Surgically Treated, Nonfunctioning Pituitary Adenomas: A Case Series. Oper Neurosurg (Hagerstown) 2019. https:// doi.org/10.1093/ons/opz085.
8.
Buchfelder M, Kreutzer J. Transcranial surgery for pituitary adenomas. Pituitary 2008; 11(4): 375–384. https://doi.org/10.1007/s11102... 0120–8.
9.
Freda PU, Beckers AM, Katznelson L, Molitch ME, Montori VM, Post KD, et al. Pituitary Incidentaloma. An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011; 96(4): 894–904. https://doi.org/10.1210/jc.201....
10.
Chandler WF, Barkan AL. Treatment of pituitary tumours: a surgical perspective. Endocrinol Metab Clin North Am. 2008; 37(1): 51–66. https://doi.org/10.1016/j.ecl.....
11.
Park P, Chandler WF, Barkan AL, Orrego JJ, Cowan JA, Griffith KA, et al. The role of radiation therapy after surgical resection of nonfunctional pituitary macroadenomas. Neurosurgery 2004; 55: 100–106.
12.
Greenman Y, Quaknine G, Veshchev I, Reider-Groswasser II, Segev Y, Stern N. Postoperative surveillance of clinically nonfunctioning pituitary macroadenomas: markers of quiescence and regrowth. Clin Endocrinol. (Oxf) 2003; 58(6): 763–769.
The Journal of Pre-Clinical and Clinical Research welcomes article
submissions and does not charge a publication fee.
Submit your article today and gain worldwide visibility for your article.
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.