RESEARCH PAPER
Tumour cell growth-inhibiting properties of water extract isolated from heated potato fibre (Potex)
| 1 | Department of Medical Biology, Institute of Agricultural Medicine, Lublin, Poland |
| 2 | Department of Virology and Immunology, Maria Curie-Skłodowska University, Lublin, Poland |
| 3 | Department of Cell and Organism Biology, Lund University, Lund, Sweden |
CORRESPONDING AUTHOR
Ewa Langner
Department of Medical Biology, Institute of Agricultural Medicine, Jaczewskiego 2, 20-950, Lublin, Poland.
Department of Medical Biology, Institute of Agricultural Medicine, Jaczewskiego 2, 20-950, Lublin, Poland.
J Pre Clin Clin Res. 2009;3(1):36–41
KEYWORDS
ABSTRACT
Commercially available potato fibres are used as a food supplement which greatly improves the texture and stability of food. Food enriched with potato fibre is often cooked, baked and roasted. Such treatment creates new compounds with potential new biological activities. The aim of the study was an in vitro evaluation of the anticancer activity of water extract obtained from heated potato fibre (Potex). An antiproliferative effect of heated Potex extract is demonstrated in all tested tumour cell cultures, including rabdomyosarcoma-medulloblastoma (TE671), glioma (C6), breast (T47D), colon (HT-29) and lung (A549) carcinoma. The study also showed that the tested extract produced remarkable morphological changes in tumour cells, decreased cancer cell motility, and induced apoptotic cell death. What is essential is that the applied concentrations of heated Potex extract did not influence the viability of normal human skin fibroblasts (HSF), rat oligodendrocytes (OLN-93) and mouse neurons. The potential role of heated potato fibre as a dietary chemopreventive is therefore suggested.
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