Introduction and objective:
The skin is the most important external organ, protecting against pathogens, physical and chemical injuries, as well as ultraviolat (UV) radiation. Continuous exposure to UV radiation, allergens, and pollutants, as well as consumption of highly processed foods, all promote the development and exacerbation of skin diseases, which appear highly differentiated. Skin diseases have a significant impact on the patient’s quality of life and psychological well-being, which is why finding effective therapeutic compounds appears to be so important, especially since multiple conditions still remain untreated. The benefits of flavonoids in the management of psoriasis, acne, atopic dermatitis, urticaria, ringworm, and other skin diseases, are discussed in this review.

Review methods:
A search was conducted using PubMed and Google Scholar databases for articles, to assess the effect of flavonoids in the prevention and treatment of skin diseases. Articles in both Polish and English were searched for. To eliminate duplicate works, the bibliography was reviewed.

Brief description of the state of knowledge:
Flavonoids’ antioxidant and photoprotective properties are the primary factors influencing their preventive use in the development of skin diseases. The risk of tumour formation is significantly reduced as a result of these two applications. They hasten the healing of long-lasting wounds and ulcers due to their circulation-stimulating properties. Plants high in flavonoids are used in dressings and poultices. Their extracts are used in creams and solutions to treat and prevent a variety of skin diseases.

The antioxidant and anti-inflammatory effects of flavonoids makes them an important reference in the treatment of skin diseases. The advancement of natural medicinal substances is a critical aspect of modern medicine.

Wyszkowska-Kolatko M, Koczurkiewicz-Adamczyk P, Wójcik-Pszczoła K, Pękala E. Medicinal plants used in skin diseases treatment. Postępy Fitoterapii. 2015;3:184–92.
Wszołek K, Piotrowska A. Plant polyphenols in cosmetology. In: Maciąg M, Maciąg K, editors. Medical aspects of cosmetology and dietetics. Lublin; 2018. p. 67–79.
Ostrowska J, Skrzydlewska E. The biological activity of flavonoids. Postępy Fitoterapii. 2005;(3–4):71–79.
Stołowska M, Kłobus G. Charakterystyka flawonoidów i ich rola w kosmetyce i terapii. Postępy Kosmetologii. Wrocław. 2010: 8–12.
Domaszewska-Szostek A, Puzianowska-Kuźnicka M, Kuryłowicz A. Flavonoids in Skin Senescence Prevention and Treatment. Int J Mol Sci. 2021;22(13):6814.
Reuter J, Merfort I, Schempp CM. Botanicals in dermatology: an evidence-based review. Am J Clin Dermatol. 2010;11(4):247–67.
Fernandes I, Pérez-Gregorio R, Soares S, Mateus N, de Freitas V. Wine Flavonoids in Health and Disease Prevention. Molecules. 2017;22(2):292.
Rorteau J, Chevalier FP, Fromy B, Lamartine J. Functional integrity of aging skin, from cutaneous biology to anti-aging strategies. Med Sci (Paris). 2020;36(12):1155–1162.
Rudyk A, Jurzak M. Składniki aktywne kosmetyków i dermokosmetyków stosowane w pielęgnacji skóry z atopowym zapaleniem. In: Goździalska A, Jaśkiewicz J, editors. Stan skóry wykładnikiem stanu zdrowia. Kraków: Oficyna Wydawnicza AFM; 2012. p.107–119.
Rajesh A, Wise L, Hibma M. The role of Langerhans cells in pathologies of the skin. Immunol Cell Biol. 2019;(8):700–713.
Rivera-Yanez CR, Ruiz-Hurtado PA, Mendoza-Ramos MI, Reyes-Reali J, García-Romo GS, Pozo-Molina G, Reséndiz-Albor AA, Nieto-Yanez O, Méndez-Cruz AR, Méndez-Catalá CF, Rivera-Yanez N. Flavonoids Present in Propolis in the Battle against Photoaging and Psoriasis. Antioxidants (Basel). 2021;10(12):2014.https://doi.org10.3390/antiox1....
Burgdorf WHC, Plewig G, Wolff HH, Landthaler M, et al. DERMATOLOGIA Braun-Falco. 3rd ed. Lublin; 2017.
Chamcheu JC, Esnault S, Adhami VM, Noll AL, Banang-Mbeumi S, Roy T, Singh SS, Huang S, Kousoulas KG, Mukhtar H. Fisetin, a 3,7,3’,4’-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models. Cells. 2019;8(9):1089.
Kuźniewski R, Krzyżyńska-Malinowska E. Naturalne surowce w terapii i profilaktyce łuszczycy. Zeszyty naukowe ALMAMER. 2014;2:43–54.
Xian D, Guo M, Xu J, Yang Y, Zhao Y, Zhong J. Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses. Redox Rep. 2021;26(1):134–146.
Soleymani S, Farzaei MH, Zargaran A, Niknam S, Rahimi R. Promising plant-derived secondary metabolites for treatment of acne vulgaris: amechanistic review. Arch Dermatol Res. 2020;312(1):5–23.
Schoelermann AM, Weber TM, Arrowitz C, Rizer RL, Qian K, Babcock M. Skin compatibility and efficacy of a cosmetic skin care regimen with licochalcone A and 4-t-butylcyclohexanol in patients with rosacea subtype I. J Eur Acad Dermatol Venereol. 2016;30(S1):21–7.
Park CH, Min SY, Yu HW, Kim K, Kim S, Lee HJ, Kim JH, Park YJ. Effects of Apigenin on RBL-2H3, RAW264.7, and HaCaT Cells: Anti-Allergic, Anti-Inflammatory, and Skin-Protective Activities. Int J Mol Sci. 2020;21(13):4620.
Wu S, Pang Y, He Y, Zhang X, Peng L, Guo J, Zeng J. A comprehensive review of natural products against atopic dermatitis: Flavonoids, alkaloids, terpenes, glycosides and other compounds. Biomed Pharmacother. 2021;140:111741.
Hosseini Farahabadi S, Tavakkol-Afshari J, Ganjali R, Rafatpanah H, Ghaffari J, Farid-Hosseini R. Association between the polymorphism of TGF-beta1 gene promoter (-509C>T) and idiopathic chronic urticaria. Iran J Allergy Asthma Immunol. 2006;5(3):109–13.
Bae JS, Kim SH, Ye YM, Yoon HJ, Suh CH, Nahm DH, Park HS. Significant association of Fc?RI? promoter polymorphisms with aspirin-intolerant chronic urticaria. J Allergy Clin Immunol. 2007;119(2):449–56.
Antia C, Baquerizo K, Korman A, Bernstein JA, Alikhan A. Urticaria: A comprehensive review: Epidemiology, diagnosis, and work-up. J Am Acad Dermatol. 2018;79(4):599–614.
Daszkiewicz M. The role of nutrition in the prevention and therapy of selected skin disorders, Aesth Cosmetol Med. 2021;10(4):175–179.
Gnat S, Łagowski D. Nowe syntetyczne i naturalne antymykotyki w kontekście terapii dermamykoz. Postępy mikrobiologii. 2020;59(1): 63–74.
Kalwa K. Właściwości antyoksydacyjne flawonidów oraz ich wpływ na zdrowie człowieka. Kosmos-problemy nauk biologicznych. 2019;68:153–159.
Kędzia B, Hołderna-Kędzia E. The use of honey in infections. Herbalism. 2020;1(6).
de Lima Cherubim DJ, Buzanello Martins CV, Oliveira Farina L, da Silva de Lucca RA. Polyphenols as natural antioxidants in cosmetics applications. J Cosmet Dermatol. 2020;(1):33–37.
Maciejewska P, Skrzypczak N. Moda na flawonoidy – o co tyle szumu? Tutoring Gedanensis. 2021;6(3):55–64.
Journals System - logo
Scroll to top