Primary spleen lymphoma visualized with contrast enhanced ultrasound – Case report
More details
Hide details
Ist Department of Medical Radiology, Medical University of Lublin
Corresponding author
Joanna Kurzepa   

Ist Department of Medical Radiology, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, Poland
J Pre Clin Clin Res. 2017;11(2):157-159
The case is reported of an extremely rare primary splenic lymphoma (PSL) and summarizes the basic concepts and techniques of contrast enhanced ultrasonography (CEUS), focusing on splenic applications for the diagnosis of malignant splenic lesions.

Case report:
A 52-year-old male with no co-morbidities presented with a history of left upper abdominal pain for one month, and chronic fatigue. Abdominal ultrasound was performed in which suspicious focal lesions in the enlarged spleen was detected, and assessed with contrast enhanced ultrasound, followed by magnetic resonance imaging (MRI). The diagnosis of malignant splenic tumour was made based on history, clinical examinations and radiographic appearance in CEUS and MRI.

In the presented case contrast enhanced ultrasound allowed establishing the diagnosis of malignancy within the spleen, which was later confirmed with MRI and histopathological examination

Kaza RK, Azar S, Al-Hawary MM, Francis IR. Primary and secondary neoplasms of the spleen. Cancer Imaging. 2010; 10: 173-82.
Caremani M, Occhini U, Caremani A, Tacconi D, Lapini L, Accorsi A, et al. Focal splenic lesions: US findings. J Ultrasound. 2013; 16: 65-74.
Vancauwenberghe T, Snoeckx A, Vanbeckevoort D, Dymarkowski S, Vanhoenacker FM. Imaging of the spleen: what the clinician needs to know. Singapore Med J. 2015; 56: 133-44.
Catalano O, Lobianco R, Sandomenico F, D'Elia G, Siani A. Real-time contrast-enhanced ultrasound of the spleen: examination technique and preliminary clinical experience. Radiol Med. 2003; 106: 338-56.
Chiavaroli R, Grima P, Tundo P. Characterization of nontraumatic focal splenic lesions using contrast-enhanced sonography. Journal of Clinical Ultrasound. 2011; 39: 310-5.
Piscaglia F, Nolsoe C, Dietrich CF, Cosgrove DO, Gilja OH, Bachmann Nielsen M, et al. The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound (CEUS): update 2011 on non-hepatic applications. Ultraschall Med. 2012; 33: 33-59.
Sutherland T, Temple F, Galvin A, Hennessy O. Contrast-enhanced ultrasound of the spleen: an introduction and pictorial essay. Insights Imaging. 2011; 2: 515-24.
Hopkins A CD, Antypa EG, Piperopolus PN. Contrast enhanced sonographic study of the spleen. Hellenic Journal of Radiology. 2017; 2: 49-65.
Dachman AH FA. Radiology of the spleen. St. Louis, MO: Mosby; 1993.
Saboo SS, Krajewski KM, O'Regan KN, Giardino A, Brown JR, Ramaiya N, et al. Spleen in haematological malignancies: spectrum of imaging findings. Br J Radiol. 2012; 85: 81-92.
Chiorean L, Zdrenghea M, Badea R. Ultrasonography of the spleen. Pictorial essay. Med Ul-trason. 2014; 16: 48-59.
Wan YL, Cheung YC, Lui KW, Tseng JH, Lee TY. Ultrasonographic findings and differen-tiation of benign and malignant focal splenic lesions. Postgrad Med J. 2000; 76: 488-93.
von Herbay A, Barreiros AP, Ignee A, Westendorff J, Gregor M, Galle PR, et al. Contrast-enhanced ultrasonography with SonoVue: differentiation between benign and malignant le-sions of the spleen. J Ultrasound Med. 2009; 28: 421-34.
Luna A VJ, da Cruz LC Jr., Rossi SE. Functional Imaging in Oncology. Clinical Applications. Berlin, Heidelberg: Springer; 2014.
Journals System - logo
Scroll to top