Mandibular odontogenic cysts associated with basal cell carcinoma in a patient with Gorlin-Goltz syndrome – Case Report
More details
Hide details
Department of Maxillofacial Surgery. Medical University of Lublin, Poland
Medical University of Lublin, Poland
Corresponding author
Anna Gaweda   

Department of Maxillofacial Surgery. Medical University of Lublin, The Medical University of Lublin, Staszica 11, 20-081 Lublin, Poland, 20-081 Lublin, Poland
J Pre Clin Clin Res. 2018;12(3):95–99
Gorlin-Goltz syndrome (GGS) is a genetic disease of autosomal dominant inheritance. It is characterized by the presence of multiple basal-cell carcinoma foci, odontogenic keratocysts and anomalies of the skin, eyes, bones, nervous and endocrine system. Patients are predisposed to various neoplasms, such as medulloblastoma and fibrosarcoma. Rare incidence of the syndrome and multi-organ manifestations require providing patients with multi-specialist care, in particular, with dermatologists, dentists and surgeons. This is a case report of a 63-year-old patient with Gorlin-Goltz syndrome treated for odontogenic keratocysts of the mandible and basal-cell carcinoma. The report includes an extensive review of the GGS with regard to its etiology, features, clinical examination, diagnostic criteria and treatment modalities
Manjima S, Naik Z, Keluskar V, Bagewadi A. Multiple jaw cyst-unveiling the Gorlin-Gotz syndrome, Contemp Clin Dent. 2015 Mar; 6(*Supp 1): 102–105.
Sirous M, Tayari N. A case report of Gorlin–Goltz syndrome as a rare hereditary disorder, J Res Med Sci. 2011 Jun; 16(6): 836–840 Available from: URL:
Khaliq M, Shah A, Ahmad I,Hasan S, Jangam S, Farah. Keratocystic odontogenic tumors realted to Gorlin-Goltz syndrome: A clinicopathological study, Craniofacial Research Foundation, 2016 May-Aug; 6(2): 93–100.
Farndon PA, Del MastroRG at al. Location of gene for Gorlin-Goltz syndrome. Lancet. 1992, 339–581–2.
Huang YF, Chen YJ, Yang HW: Nevoid basal cell carcinoma syndrome – case report and genetic study. J Dent Sciences, 2010; 5: 166–70 14.
Ramesh M., Krishanan R., Chalakkal P., Paul G. Gorlin-Goltz Syndrome: Case report and literature review. J Oral Maxillofac Path.2015, 19, 2:267–79.
Kiwilsza M, Sporniak-Tutak K. Gorlin-Goltz syndrome – a medical condition requiring a multidisciplinary approach, Med Sci Monit, 2012; 18(9); RA145–153.
Deneswari M, Reddy MSR. Genetic mutations in Gorlin-Goltz-syndrom. Indian J Hum.Genet.2013, 19,3,369–372.
Burdgorf WHC, Plewing G, Wolf HH, Landhaler M.Braun-FalcoDermatologia. Carcinoma basocellulare. Refenberg J.Ruzicka T.Wydaw.Czelej, Lublin 2011, 1378–1379.
Kulkarni GH, Khaji SI, Kulkarni R. Multiple keratocysts of the mandible in association with Gorlin-Goltz syndrome: A rare case report. Contemp Clin Dent. 2014 Jul-Sep; 5(3): 419–421.
Manfredi M, Vescovi P, Bonanini M, Porter S. Basal cell carcinoma syndrome: a review of the literature Int. J. Oral Maxillofac. Surg. 2004; 33: 117–124 Nevoid.
KimonisVE, Golddstein AM, Pastiakia B at al. Clinical manifestation in 105 persons with nevoid basal cell carcinoma syndrome. Am J Med Genet. 1997,69,299–308.
Alanna F. Bree and Maulik R. Shah for the BCNS Colloquium Group. 2011. Consensus Statement From the First International Colloquium on Basal Cell Nevus Syndrome(BCNS) Am J. of medical genetics Part A 155:2091–2097.
Borzecki A, Pilat P, Raszewska-Famielec M, Pilat J. Combination therapy of basal-cell carcinoma in 31-year-old patient with nevoid basal cell carcinoma syndrome – Case study, JPCCR, 2016, Vol 10, No 1, 66–68.
Brzozowski F, Wanyura H, Stopa Z, Kowalska K. Odontogenic keratocysts in the material of the Department of Craniomaxillofacila Surgery, Medical University of Warsaw. Czas Stomatol, 2010; 2: 69–78 24.
Booth PW, Schendel SA, Hausamen JE, Maxillofacial Surgery, Second Edition, Volume 1, Churchill Livingstone Elsevier, 2006.
Bahadure RN, Jain ES, Badole GP, Gorlin and Goltz Syndrome. A Case Report with Surgical Review, Int J Clin Pediatr Dent. 2013 May-Aug; 6(2): 104–108 Available from: doi: 10.5005/jp-journals-10005-1199.