Benign pancreatic hyperenzymemia (BPH) or Gullo’s Syndrome is a persistent elevation of pancreatic enzymes activity, observed for at least one year, with no pancreatic disorder. This diagnosis is extremely important because it allows us to avoid many unnecessary examinations performed during the diagnostic process. The case is presented of a 25-year-old man who was examined for recurrent elevated lipase and amylase serum values over a time period of 2 years who presentedwith non-specific abdominal complaints. Interestingly, his routine tests showed sustained elevated serum amylase and lipase activity. He was intensively diagnosed due to pancreatic hyperenzymemia, but no pancreatic disease was detected. The observation lasted two years. The serum lipase and serum amylase levels continued to increase after that time. This diagnosis requires attention because BPH can be the first symptom of pancreatic cancer.
BPH – benign pancreatic hyperenzymemia PE – pancreatic enzymes HIV – human immunodeficiency virus CEA – carcinoembryonic antigen CA19-9 – carbohydrate antigen 19-9 AFP – alpha-fetoprotein CA125 – carbohydrate antigen 125 NOD2 – nucleotide-binding oligomerization domain containing 2 PRSS1 – serine protease 1 SPINK1 – serine protease inhibitor Kazal-type 1 CAPH – chronic asymptomatic pancreatic hyperenzymemia EUS – endoscopic ultrasonography s-MRCP – secretin-magnetic resonance cholangiopancreatography MRCP – magnetic resonance cholangio-pancreatography
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The authors declare that they have no competing interests.
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