The study presents an atypical location of Non-Hodgkin lymphoma of the oral cavity in the area of the palate. Pathological changes of the mucosa of the palate in an 85-year-old female patient had been developing for many years as a result of upper denture irritation without any major symptoms. Histological examination revealed a Diffuse large B cell lymphoma. Due to being advanced in years, the patient was qualified for the local radiotherapy. In this particular case, the clinical picture of lymphoma imitated an inflammation of the mucosa of the oral cavity which resulted in delayed diagnosis and treatment.
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