Vitamin D3 levels in healthy people, including a group aged over 60, in relation to BMI
More details
Hide details
Faculty of Medicine, University of Rzeszow, Poland
Subcarpathian Centre of Lung Diseases – Clinic of Pulmonology and Allergology, Rzeszow, Poland
Department of Hygiene of Nutrition and Epidemiology, Medical University, Lodz, Poland
JPCCR 2017;11(1):25–29
Vitamin D plays a role not only in the remodeling of bone, but also in functions involving other organs. Its tissue availability depends on dermal synthesis and/or ingestion from diet, as well as on the amount of adipose tissue binding vitamin D into its cells. This study evaluates vitamin D concentrations in relation to body-mass index (BMI) in healthy people aged over 60 and living in the Subcarpathian Province of southeastern Poland. The study involved 246 participants – 172 women (69.9%), 74 men (31,1%), with an average age of 65.9 (±11.9). The mean concentrations of vitamin D, assessed with ECLIA method, was 18 ng/ml, which indicates a marked deficiency in vitamin D. Defined vitamin D deficiency (<20ng/ml) was noted in 62% of participants without any difference between males and females. There was no correlation between BMI and vitamin D deficiency in the studied group. The results suggest the need for vitamin supplementation in healthy people aged over 60 according to the guidelines
Sławomir Tokarski
Sławomir Tokarski MD PhD, ul. Rycerska 2, 35-241 Rzeszów, Poland
1. Holick M. Vitamin D deficiency. N Engl J Med. 2007; 357: 266–281.
2. Armas LA, Dowell S, Akhter M, et al. Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: the effect of UVB dose and skin color. J Am Acad Dermatol. 2007; 57: 588–593.
3. Alpert PT, Shaikh U. The effects of vitamin D deficiency and insufficiency on the endocrine and paracrine systems. Biol Res Nurs. 2007; 9: 117–129.
4. Grygiel-Górniak B, Puszczewicz M. Witamina D – nowe spojrzenie w medycynie i reumatologii. Postępy Hig Med Dosw (online) 2014; 68: 359–368.
5. Pawliczak R. Witamina D – znaczenie w chorobach obturacyjnych. Zjawisko stare, dane kliniczne nowe. Terapia 2014; 9(2): 21–25.
6. Bonakdar ZS, Jahanshahifar L, Jahanshahifar F, Gholamrezaei A. Vitamin D deficiency and its association with disease activity in new cases of systemic lupus erythematosus. Lupus, 2011; 20: 1155–1160.
7. Haussler MR, Norman A. Chromosomal receptor for a vitamin D metabolite. Proc Natl Acad Sci. USA, 1969; 62: 155–162.
8. DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004; 80: 1689–1696.
9. DeLuca HF, Cantorna M. Vitamin D: its role and uses in immunology. FASEB J, 2001; 15: 2579–2585.
10. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J ClinNutr. 2008; 87(4): 1080–1086.
11. Abbas MA. Physiological functions of vitamin D in adipose tissue. J Steroid Biochem Mol Biol. 2017; 165: 369–381.
12. Koszowska AU, Nowak J, Dittfeld A, et al. Obesity, adipose tissue function and the role of vitamin D. Centr Eur J Immunol. 2014; 39: 260–264.
13. Mehmood ZTNH. Papandreou D: An updated mini review of vitamin D and obesity: adipogenesis and inflammation state. Open Access Maced. J Med. 2016; 4: 526–532.
14. Bruyere O, Slomian J, Beaudart C, et al. Prevalence of vitamin D inadequacy in European women aged over 80 years. Arch Gerontol Geriatr. 2014; 59: 78–82.
15. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001; 22: 477–501.
16. Charzewska J, Chlebna-Sokół D, Chybicka A. i wsp. Aktualne (2009) polskie zalecenia dotyczące profilaktyki niedoboru witaminy D. Med. Prakt Pediatr. 2010; 1: 40–46.
17. Karczmarewicz E, Czekuć-Kryśkiewicz E, Płudowski P. Effect of vitamin D status on pharmacological treatment efficiency. Dermatoloendocrinol. 2013; 5: 1–6.
18. Marcinkowska-Suchowierska E, Walicka M. Niedobory witaminy D -narastający problem społeczny. Fam Med Prim Care Rev. 2009; 11: 691–69.
19. Kramer J, Diehl A, Lehnert H. Epidmiological study on the dimension of vitamin D deficiency in North Germany. Dtsch Med Wochenschr. 2014; 139(10): 470–475.
20. Valtueňa J, Gonzales-Gross M, Hybrechts I, et al. Factors associatedwith vitamin D defficiency in European adolescens: the Helena Study. J Nutr Sci Vitaminol. 2013; 59(3): 161–171.
21. Kaehler ST, Baumgartner H, Jeske M, et al. Prevalence of hypovitaminosis D and folate deficiency in healthy young female Austrian students in a health care profession. Eur J Nut. 2012; 51(8): 1021–1031.
22. Marcinkowska-Suchowierska E, Walicka M. Niedobory witaminy D – narastający problem społeczny. Fam Med Prim Care Rev. 2009; 11: 691–698.
23. Bruyere O, Malaise O, Neuprez A, et al. Prevalence of vitamin D inadequacy in European postmenopausal women. Curr Med Res Opin. 2007; 23(8): 1939–1944.
24. Gaugris S, Heaney RP, Boonen S, et al. Vitamin D inadequacy among postmenopausal women: a systematic review. QJM. 2005; 98(9): 667–676.
25. Merlo C, Ross C, Trummler M, et al. Prevalence and symptoms of vitamin D deficiency in general practice. Praxis. 2012; 101(22): 1417– 1422.
26. Napiórkowska L, Budlewski T, Jakubas-Kwiatkowska i wsp. Częstość występowania małego stężenia witaminy D w surowicy starszych kobiet w Polsce. Pol Arch Med Wewn. 2009; 119: 669.
27. Kaczmarewicz E, Łukaszkiewicz J, Lorenc R. Witamina D — mechanizm działania, badania epidemiologiczne, zasady suplementacji. Lab Forum 2007; 11: 3–8.
28. Lucas J, Bolland M, Grey A, et al. Determinants of vitamin D status in older women living in a subtropical climate. Osteoporo Int. 2005; 16: 1641–1648.
29. Saadi H, Nagelkerke N, Benedict S, et al. Predictors and relationships of serum 25-hydroxyvitamin D concentration with bone turnover markers, bone mineral density, and vitamin D receptor genotype in Emirati women. Bone 2006; 39: 1136–1143.
30. Hannemann A, Thuesen BH, Friedrich N et al. Adiposity measures and vitamin D concentrations in Northeast Germany and Denmark. Nutr Metab (Lond). 2015; 10,12: 24.
31. Czerwińska E, et al. Calcium homeostasis and biochemical markers of bone turnover in patients with morbid obesity. Obesity Reviews 2006; 7(Suppl 2): 139.
32. Dhaliwal R, Mikhail M, Feuerman M et al. The vitamin d dose response in obesity. EndocrPract. 2014; 20: 12.
33. Wortsman J, et al. Decreased bioavailability of vitamin D in obesity.Am J Clin Nutr. 2000; 72: 690–693.