RESEARCH PAPER
Vitamin D3 levels in healthy people, including a group aged over 60, in relation to BMI
1, 2,
3
| 1 | Faculty of Medicine, University of Rzeszow, Poland |
| 2 | Subcarpathian Centre of Lung Diseases – Clinic of Pulmonology and Allergology, Rzeszow, Poland |
| 3 | Department of Hygiene of Nutrition and Epidemiology, Medical University, Lodz, Poland |
JPCCR 2017;11(1):25–29
KEYWORDS:
ABSTRACT:
Vitamin D plays a role not only in the remodeling of bone, but also in functions involving other organs. Its tissue availability depends on dermal synthesis and/or ingestion from diet, as well as on the amount of adipose tissue binding vitamin D into its cells. This study evaluates vitamin D concentrations in relation to body-mass index (BMI) in healthy people aged over 60
and living in the Subcarpathian Province of southeastern Poland. The study involved 246 participants – 172 women (69.9%), 74 men (31,1%), with an average age of 65.9 (±11.9). The mean concentrations of vitamin D, assessed with ECLIA method, was 18 ng/ml, which indicates a marked deficiency in vitamin D. Defined vitamin D deficiency (<20ng/ml) was noted in 62%
of participants without any difference between males and females. There was no correlation between BMI and vitamin D deficiency in the studied group. The results suggest the need for vitamin supplementation in healthy people aged over 60 according to the guidelines
CORRESPONDING AUTHOR:
Sławomir Tokarski
Sławomir Tokarski MD PhD, ul. Rycerska 2, 35-241 Rzeszów, Poland
REFERENCES (33):
| 1. | Holick M. Vitamin D deficiency. N Engl J Med. 2007; 357: 266–281. |
| 2. | Armas LA, Dowell S, Akhter M, et al. Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: the effect of UVB dose and skin color. J Am Acad Dermatol. 2007; 57: 588–593. |
| 3. | Alpert PT, Shaikh U. The effects of vitamin D deficiency and insufficiency on the endocrine and paracrine systems. Biol Res Nurs. 2007; 9: 117–129. |
| 4. | Grygiel-Górniak B, Puszczewicz M. Witamina D – nowe spojrzenie w medycynie i reumatologii. Postępy Hig Med Dosw (online) 2014; 68: 359–368. |
| 5. | Pawliczak R. Witamina D – znaczenie w chorobach obturacyjnych. Zjawisko stare, dane kliniczne nowe. Terapia 2014; 9(2): 21–25. |
| 6. | Bonakdar ZS, Jahanshahifar L, Jahanshahifar F, Gholamrezaei A. Vitamin D deficiency and its association with disease activity in new cases of systemic lupus erythematosus. Lupus, 2011; 20: 1155–1160. |
| 7. | Haussler MR, Norman A. Chromosomal receptor for a vitamin D metabolite. Proc Natl Acad Sci. USA, 1969; 62: 155–162. |
| 8. | DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004; 80: 1689–1696. |
| 9. | DeLuca HF, Cantorna M. Vitamin D: its role and uses in immunology. FASEB J, 2001; 15: 2579–2585. |
| 10. | Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J ClinNutr. 2008; 87(4): 1080–1086. |
| 11. | Abbas MA. Physiological functions of vitamin D in adipose tissue. J Steroid Biochem Mol Biol. 2017; 165: 369–381. |
| 12. | Koszowska AU, Nowak J, Dittfeld A, et al. Obesity, adipose tissue function and the role of vitamin D. Centr Eur J Immunol. 2014; 39: 260–264. |
| 13. | Mehmood ZTNH. Papandreou D: An updated mini review of vitamin D and obesity: adipogenesis and inflammation state. Open Access Maced. J Med. 2016; 4: 526–532. |
| 14. | Bruyere O, Slomian J, Beaudart C, et al. Prevalence of vitamin D inadequacy in European women aged over 80 years. Arch Gerontol Geriatr. 2014; 59: 78–82. |
| 15. | Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001; 22: 477–501. |
| 16. | Charzewska J, Chlebna-Sokół D, Chybicka A. i wsp. Aktualne (2009) polskie zalecenia dotyczące profilaktyki niedoboru witaminy D. Med. Prakt Pediatr. 2010; 1: 40–46. |
| 17. | Karczmarewicz E, Czekuć-Kryśkiewicz E, Płudowski P. Effect of vitamin D status on pharmacological treatment efficiency. Dermatoloendocrinol. 2013; 5: 1–6. |
| 18. | Marcinkowska-Suchowierska E, Walicka M. Niedobory witaminy D -narastający problem społeczny. Fam Med Prim Care Rev. 2009; 11: 691–69. |
| 19. | Kramer J, Diehl A, Lehnert H. Epidmiological study on the dimension of vitamin D deficiency in North Germany. Dtsch Med Wochenschr. 2014; 139(10): 470–475. |
| 20. | Valtueňa J, Gonzales-Gross M, Hybrechts I, et al. Factors associatedwith vitamin D defficiency in European adolescens: the Helena Study. J Nutr Sci Vitaminol. 2013; 59(3): 161–171. |
| 21. | Kaehler ST, Baumgartner H, Jeske M, et al. Prevalence of hypovitaminosis D and folate deficiency in healthy young female Austrian students in a health care profession. Eur J Nut. 2012; 51(8): 1021–1031. |
| 22. | Marcinkowska-Suchowierska E, Walicka M. Niedobory witaminy D – narastający problem społeczny. Fam Med Prim Care Rev. 2009; 11: 691–698. |
| 23. | Bruyere O, Malaise O, Neuprez A, et al. Prevalence of vitamin D inadequacy in European postmenopausal women. Curr Med Res Opin. 2007; 23(8): 1939–1944. |
| 24. | Gaugris S, Heaney RP, Boonen S, et al. Vitamin D inadequacy among postmenopausal women: a systematic review. QJM. 2005; 98(9): 667–676. |
| 25. | Merlo C, Ross C, Trummler M, et al. Prevalence and symptoms of vitamin D deficiency in general practice. Praxis. 2012; 101(22): 1417– 1422. |
| 26. | Napiórkowska L, Budlewski T, Jakubas-Kwiatkowska i wsp. Częstość występowania małego stężenia witaminy D w surowicy starszych kobiet w Polsce. Pol Arch Med Wewn. 2009; 119: 669. |
| 27. | Kaczmarewicz E, Łukaszkiewicz J, Lorenc R. Witamina D — mechanizm działania, badania epidemiologiczne, zasady suplementacji. Lab Forum 2007; 11: 3–8. |
| 28. | Lucas J, Bolland M, Grey A, et al. Determinants of vitamin D status in older women living in a subtropical climate. Osteoporo Int. 2005; 16: 1641–1648. |
| 29. | Saadi H, Nagelkerke N, Benedict S, et al. Predictors and relationships of serum 25-hydroxyvitamin D concentration with bone turnover markers, bone mineral density, and vitamin D receptor genotype in Emirati women. Bone 2006; 39: 1136–1143. |
| 30. | Hannemann A, Thuesen BH, Friedrich N et al. Adiposity measures and vitamin D concentrations in Northeast Germany and Denmark. Nutr Metab (Lond). 2015; 10,12: 24. |
| 31. | Czerwińska E, et al. Calcium homeostasis and biochemical markers of bone turnover in patients with morbid obesity. Obesity Reviews 2006; 7(Suppl 2): 139. |
| 32. | Dhaliwal R, Mikhail M, Feuerman M et al. The vitamin d dose response in obesity. EndocrPract. 2014; 20: 12. |
| 33. | Wortsman J, et al. Decreased bioavailability of vitamin D in obesity.Am J Clin Nutr. 2000; 72: 690–693. |
Related articles
