RESEARCH PAPER
No eff ect of water extract of Scutellariae radix on the anticonvulsant action
of valproate, tiagabine and topiramate in two animal models of epilepsy
1
Department of Physiopathology, Institute of Agricultural Medicine, Lublin, Poland
2
Department of Pathophysiology, Medical University, Lublin, Poland
Corresponding author
Marta Andres-Mach
Department of Physiopathology, Institute of Agricultural Medicine, Jaczewskiego 2, 20-090 Lublin, Poland.
Department of Physiopathology, Institute of Agricultural Medicine, Jaczewskiego 2, 20-090 Lublin, Poland.
J Pre Clin Clin Res. 2009;3(2):95-98
KEYWORDS
ABSTRACT
Water extract of Scutellariae radix (SR) was previously reported to display a signifi cant anticonvulsant eff ect on maximal electroshock (MES)-induced seizures, and little anticonvulsant eff ect in pentylenetetrazole (PTZ)-induces
clonic seizure model in mice. The aim of this study was to examine whether water extract of SR has any impact on anticonvulsant properties of valproate (VPA) and tiagabine (TGB) in PTZ-induced clonic seizure model in mice and
VPA and topiramat (TPM) in the mouse MES test. Results indicated that water extract of SR did not signifi cantly aff ect the anticonvulsant action of VPA and TPM against MES-induced tonic seizures. The experimentally derived median eff ective doses (ED50 values) for VPA administered alone and in combination with water extract of SR were 219 and 203 mg/kg and for TPM administered alone, and in combinations with water extract of SR were 41.6 and 40.8 mg/kg, respectively. Likewise, no eff ect of water extract of SR was observed on VPA and TGB in PTZ-induced clonic seizure models. The ED50 values for TGB administered alone and in combination with water extract of SR were 0.84 and 0.71 mg/kg, while those for VPA were 158 and 129 mg/kg, respectively. In conclusion, water extract of SR had no eff ect on the anticonvulsant activity of TPM and VPA in the mouse MES seizure model and on the antiseizure activity of VPA and TGB in PTZ-induced clonic seizures in mice.
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