Metallothioneins in neoplastic cells – distribution in subfractions
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1. Department of Environmental Hygiene, Institute of Agricultural Medicine, Lublin, Poland; 2. Department of Neurosurgery and Children’s Neurosurgery Clinic, Medical University, Lublin, Poland
Department of Neurosurgery and Children’s Neurosurgery Clinic, Medical University, Lublin, Poland
J Pre Clin Clin Res. 2007;1(2):182–184
Metallothioneins are intracellular macromolecules with a high potential for binding metallic ions. They are proteins which bind metals indispensable for the organism, as well as proteins which have found their way into the body by chance as a result of environmental pollution (e.g. cadmium, lead). Further studies have shown that the content of metallothioneins rises in neoplastic cells. Apart from metals entering a cell, metallothionein synthesis induction can be triggered by some inflammatory agents or reactive forms of oxygen. It follows from the studies of metallothionein content in a cell that these proteins are present in all cellular subfractions, and the highest content of metallotioneins is present in the cytosol subfraction. It has been found that the cellular subfractions of a neoplasm are characterized by significant changes in the distribution of metallothioneins.
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