RESEARCH PAPER
Effect of three glutamatergic metabotropic receptor ligands on electrically-induced seizures in mice
 
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Experimental Neuropathophysiology Unit, Department of Pathophysiology, Medical University, Lublin, Poland
CORRESPONDING AUTHOR
Kinga Borowicz   

Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland.
 
J Pre Clin Clin Res. 2007;1(1):47–48
 
KEYWORDS
ABSTRACT
The objective of this study was to determine whether the effect of 3 agonists of glutamatergic metabotropic receptors (mGluRs): ACPT, DCPG, MTPG. ACPT and DCPG (agonists of mGluR III receptors) administered at the dose of 20 mg/kg increased the electroconvulsive threshold in mice. In contrast, MTPG, an agonist of mGluR II and mGluR III receptors, applied at the same dose (20 mg/kg) significantly decreased the threshold, presenting proconvulsant action. This surprising effect may be due to agonistic properties of MTPG towards mGluR II receptors.
 
REFERENCES (10)
1.
Danysz W, Sopala M: Jonotropowe receptory glutaminianergiczne. Farm Pol 2000, 56, 9-14.
 
2.
Acher FC, Tellier FJ, Azerad R, Brabet IN, Fagni L, Pin JP: Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J Med Chem 1997, 40, 3119-3129.
 
3.
Thomas NK, Wright RA, Howson PA, Kingston AE, Schoepp DD, Jane DE: (S)-3,4-DCPG, a potent and selective mGluR8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology 2001, 40, 311-315.
 
4.
Chapman AG, Talebi A, Yip PK, Meldrum BS: Anticonvulsant activity of a mGlu4α receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane- 1,2,4 tricarboxylic acid. Eur J Pharmacol 2001, 424, 107-113.
 
5.
Jane DE, Pittaway K, Sunter DC, Thomas NK, Watkins JC: New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. Neuropharmacology 1995, 34, 851-856.
 
6.
Moldrich RX, Chapman AG, De Sarro G, Meldrum BS: Glutamate metabotropic receptors as targets for drug therapy in epilepsy. Eur J Pharmacol 2003, 476, 3-16.
 
7.
Litchfield JT, Wilcoxon F: A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 1949, 96, 99-113.
 
8.
Shigemoto R, Kinoshita A, Wada E, Nomura S, Ohishi H, Takada M, Flor PJ, Neki A, Abe T, Nakanishi S, Mizuno N: Differential presynaptic localization of metabotropicglutamate receptor subtypes in the rat hippocampus. J Neurosci 1997, 17, 7503-7522.
 
9.
Folbergrova J, Haugvicova R, Mares P: Attenuation of seizures induced by metabotropic glutamate group II and group III receptor agonists. Brain Res 2001, 908, 120-129.
 
10.
Borowicz KK, Kaminski R, Gąsior M, Kleinrok Z, Czuczwar SJ: Influence of melatonin upon the protective action of conventional antiepileptic drugs against maximal electroshock in mice. Eur Neuropharmacol 1999, 9, 185-190.
 
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