REVIEW PAPER
 
KEYWORDS
TOPICS
ABSTRACT
Introduction and objective:
Metabolic disorders are associated with a number of negative health consequences. Therefore, the aim of this review was to define the relationships between overweight and obesity, lipid metabolism disorders, hypertension, disorders of carbohydrate metabolism, and cognitive functions.

Abbreviated description of the state of knowledge:
Metabolic disorders may be linked to the reduction of cognitive functions, such as memory, abstract reasoning, verbal fluency, attention and psychomotor speed. Obesity may lead to changes in the hippocampus, one of the main structures involved in learning and memory. The evidence reviewed suggests that obesity, by inducing inflammation, leads to the dysfunction of brain structures such as the frontal cortex and corpus callosum involved in plasticity processes and cognitive functions. In addition, obesity has been found to be associated with abnormalities in the white matter and glial cells in the brain, which may also cause reduction in processing speed. It is possible that there is a non-linear relationship between lipids and cognitive function moderated by age and the pro-inflammatory process. Disturbances in carbohydrate metabolism can also lead to cognitive impairment, such as: memory, verbal fluency or abstract reasoning.

Conclusions:
Metabolic disorders are associated with a higher risk of developing cognitive impairment. This association can be moderated by additional factors: lifestyle, oxidative stress, pro-inflammatory processes, genetic factors, age and education.

Łopuszańska U, Cholewa K, Kozyra M. Cognitive consequences of metabolic disorders. J Pre-Clin Clin Res. doi: 10.26444/jpccr/129264
 
REFERENCES (64)
1.
Cornejo MP, Hentges ST, Maliqueo M, et al. Neuroendocrine Regulation of Metabolism. J Neuroendocrinol. 2016; 28(7): 10.1111/jne.12395. ht t ps://doi.org /10.1111/jne.12395.
 
2.
Hruby A, Hu FB. The Epidemiology of Obesity: A Big Picture. Pharmacoeconomics. 2015; 33(7): 673–689. https://doi.org/10.1007/s40273....
 
3.
Afshin A, Forouzanfar MH, Reitsma MB, et al. Health Effects of Overweight and Obesity in 195 Countries over 25 Years. N Engl J Med. 2017; 6;377(1): 13–27. https://doi.org/10.1056/NEJMoa....
 
4.
Mellendijk L, Wiesmann M, Kiliaan AJ. Impact of Nutrition on Cerebral Circulation and Cognition in the Metabolic Syndrome. Nutrients. 2015; 7(11): 9416–39. https://doi.org/10.3390/nu7115....
 
5.
Shi TH, Wang B, Natarajan S. The Influence of Metabolic Syndrome in Predicting Mortality Risk Among US Adults: Importance of Metabolic Syndrome Even in Adults With Normal Weight. Prev Chronic Dis. 2020; 17: 200020. http://dx.doi.org/10.5888/pcd1....
 
6.
Değirmenci T, Kalkan-Oğuzhanoğlu N, Sözeri-Varma G, Özdel O, Fenkçi S. Psychological Symptoms in Obesity and Related Factors. Noro Psikiyatr Ars. 2015; 52(1): 42–46. https://doi.org/10.5152/npa.20....
 
7.
Fulton M, Srinivasan VN. Obesity, Stigma And Discrimination. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2020. https://www.ncbi.nlm.nih.gov/b..., (access 10.10.2020).
 
8.
Anstey KJ, Cherbuin N, Budge M, et al. Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies. Obes Rev. 2011; 12(5): 426–37. https://doi.org/10.1111/j.1467....
 
9.
Guicciardi M, Crisafulli A, Doneddu A, Fadda D, Lecis R. Effects of Metabolic Syndrome on Cognitive Performance of Adults During Exercise. Front Psychol. 2019; 10: 1845. https://doi.org/10.3389/fpsyg.....
 
10.
Gunstad J, Strain G, Devlin J, et al. Improved memory function 12 weeks after bariatric surgery. Surg Obes Relat Dis. 2011; 7(4): 465–472. https://doi.org/10.1016/j.soar....
 
11.
Stanek KM, Grieve SM, Brickman AM, et al. Obesity is associated with reduced white matter integrity in otherwise healthy adults. Obesity (Silver Spring). 2011; 19(3): 500–4. https://doi.org/10.1038/oby.20....
 
12.
Hou Q, Guan Y, Yu W, et al. Associations between obesity and cognitive impairment in the Chinese elderly: an observational study. Clin Interv Aging. 2019; 14: 367–373, https://doi.org/10.2147/CIA.S1....
 
13.
Cheng J, East P, Blanco E, et al. Obesity leads to declines in motor skills across childhood. Child Care Health Dev. 2016; 42(3): 343–350. https://doi.org /10.1111/cch.12336.
 
14.
Gustafson DR, Bäckman K, Joas E, et al. 37 years of body mass index and dementia: observations from the prospective population study of women in Gothenburg, Sweden. J Alzheimers Dis. 2012; 28(1): 163–71. https://doi.org/10.3233/JAD-20....
 
15.
Anjum I, Fayyaz M, Wajid A, et al. Does Obesity Increase the Risk of Dementia: A Literature Review. Cureus. 2018; 10(5): e2660. https://doi.org/10.7759/cureus....
 
16.
Ellulu MS, Patimah I, Khaza’ai H, et al. Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci. 2017; 13(4): 851–863. https://doi.org/10.5114/aoms.2....
 
17.
Wersching H, Duning T, Lohmann H, et al. Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function. Neurology. 2010; 74(13): 1022–9. https://doi.org/10.1212/WNL.0b....
 
18.
Roy A, Jana M, Corbett GT, et al. Regulation of CREB and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor α. Cell Rep. 2013; 4(4): 724–737. https://doi.org/10.1016/j.celr....
 
19.
Vainik U, Baker TE, Dadar M, et al. Neurobehavioral correlates of obesity are largely heritable. Proc Natl Acad Sci USA. 2018; 115(37): 9312–9317. https://doi.org/10.1073/pnas.1....
 
20.
Linton MRF, Yancey PG, Davies SS, et al. The Role of Lipids and Lipoproteins in Atherosclerosis. [Updated 2019 Jan 3]. In: Feingold KR, Anawalt B, Boyce A, et al, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000, https://www.ncbi.nlm.nih.gov/b... (access 18.09.2020).
 
21.
Kraal AZ, Moll AC, Arvanitis NR, et al. Metabolic syndrome is negatively associated with cognition among endothelial nitric oxide synthase (eNOS)- 786C carriers in schizophrenia-spectrum disorders. J Psychiatr Res. 2019; 117: 142–147. https://doi.org/10.1016/j.jpsy....
 
22.
Ancelin ML, Ripoche E, Dupuy AM, et al. Gender-specific associations between lipids and cognitive decline in the elderly. Eur Neuropsychopharmacol. 2014; 24(7): 1056 – 66. https://doi.org/10.1016/j.euro....
 
23.
He Q, Li Q, Zhao J, et al. Relationship between plasma lipids and mild cognitive impairment in the elderly Chinese: a case-control study. Lipids Health Dis. 2016; 15(1): 146. https://doi.org/10.1186/s12944....
 
24.
Liu Y, Chan DKY, Thalamuthu A, et al. Plasma lipidomic biomarker analysis reveals distinct lipid changes in vascular dementia. Comput Struct Biotechnol J. 2020; 18: 1613–1625. https://doi.org/10.1016/j.csbj....
 
25.
Wendell CR, Zonderman AB, Katzel LI, et al. Nonlinear associations between plasma cholesterol levels and neuropsychological function. Neuropsychology. 2016; 30(8): 980–987. https://doi.org/10.1037/neu000....
 
26.
Liu Y, Chan DKY, Thalamuthu A, et al. Plasma lipidomic biomarker analysis reveals distinct lipid changes in vascular dementia. Comput Struct Biotechnol J. 2020; 18: 1613–1624. https://doi.org/10.1016/j.csbj....
 
27.
Leritz EC, McGlinchey RE, Salat DH, et al. Elevated levels of serum cholesterol are associated with better performance on tasks of episodic memory. Metab Brain Dis. 2016; 31(2): 465–473. https://doi.org/10.1007/s11011....
 
28.
Morley JE, Banks WA. Lipids and cognition. J Alzheimers Dis. 2010; 20(3): 737–47. https://doi.org/10.3233/JAD-20....
 
29.
Tsoupras A, Lordan R, Zabetakis I. Inflammation, not Cholesterol, Is a Cause of Chronic Disease. Nutrients. 2018; 10(5): 604. https://doi.org/10.3390/nu1005....
 
30.
Bojar I, Wojcik-Fatla A, Owoc A, et al. Polymorphisms of apolipoprotein E gene and cognitive functions of postmenopausal women, measured by battery of computer tests – Central Nervous System Vital Signs. Neuro Endocrinol Lett. 2012; 33(4): 385–92.
 
31.
Bojar I, Owoc J, Wójcik-Fatla A, et al. Cognitive functions, lipid profile, and Apolipoprotein E gene polymorphism in postmenopausal women. Ann Agric Environ Med. 2015; 22(2): 313–9. https://doi.org/10.5604/123219....
 
32.
Tan BL, Norhaizan ME. Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function. Nutrients. 2019; 11(11): 2579. ht t ps://doi.org /10.3390/nu11112579.
 
33.
Mergenthaler P, Lindauer U, Dienel GA, et al. Sugar for the brain: the role of glucose in physiological and pathological brain function. Trends Neurosci. 2013; 36(10): 587–597. https://doi.org/10.1016/j.tins....
 
34.
Zanchi D, Meyer-Gerspach AC, Schmidt A, et al. Acute Effects of Glucose and Fructose Administration on the Neural Correlates of Cognitive Functioning in Healthy Subjects: A Pilot Study. Front Psychiatry. 2018; 9: 71. https://doi.org/10.3389/fpsyt.....
 
35.
Papunen S, Mustakallio-Könönen A, Auvinen J, et al. The association between diabetes and cognitive changes during aging. Scand J Prim Health Care. 2020; 38(3): 281–290. https://doi.org/10.1080/028134....
 
36.
Chong CP, Shahar S, Haron H, et al. Habitual sugar intake and cognitive impairment among multi-ethnic Malaysian older adults. Clin Interv Aging. 2019; 14: 1331–1342. https://doi.org/10.2147/CIA.S2....
 
37.
Mortby ME, Janke AL, Anstey KJ, et al. High “Normal” Blood Glucose Is Associated with Decreased Brain Volume and Cognitive Performance in the 60s: The PATH through Life Study. PLoS One. 2013; 8(9): 73697. https://doi.org/10.1371/journa....
 
38.
Qiu Q, Lin X, Sun L, et al. Cognitive decline is related to high blood glucose levels in older Chinese adults with the ApoE ε3/ε3 genotype. Transl Neurodegener. 2019; 8: 12, https://doi.org/10.1186/s40035....
 
39.
Moheet A, Mangia S, Seaquist ER. Impact of diabetes on cognitive function and brain structure. Ann N Y Acad Sci. 2015; 1353: 60–71. ht t ps://doi.org /10.1111/nyas.12807.
 
40.
Kerti L, Witte AV, Winkler A, et al. Higher glucose levels associated with lower memory and reduced hippocampal microstructure. Neurology. 2013; 81(20): 1746–52. https://doi.org/10.1212/01.wnl....
 
41.
Prasad S, Sajja RK, Naik P, Cucullo L. Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview. J Pharmacovigil. 2014; 2(2): 125. https://doi.org/10.4172/2329-6....
 
42.
Kim B & Feldman EL. Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome. Exp Mol Med. 2015: 47(3): 149. https://doi.org/10.1038/emm.20....
 
43.
Gudala K, Bansal D, Schifano F, et al. Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies. J Diabetes Investig. 2013; 4(6): 640–650. https://doi.org/10.1111/jdi.12....
 
44.
Zilliox LA, Chadrasekaran K, Kwan JY, et al. Diabetes and Cognitive Impairment. Curr Diab Rep. 2016; 16(9): 87. https://doi.org/10.1007/s11892....
 
45.
Nazaribadie M, Amini M, Ahmadpanah M, et al. Executive functions and information processing in patients with type 2 diabetes in comparison to pre-diabetic patients. J Diabetes Metab Disord. 2014; 13(1): 27. https://doi.org/10.1186/2251-6....
 
46.
Kim HG. Cognitive dysfunctions in individuals with diabetes mellitus. Yeungnam Univ J Med. 2019; 36(3): 183–191. https://doi.org/10.12701/y ujm.2019.00255.
 
47.
Chudiak A, Uchmanowicz I, Mazur G. Relation between cognitive impairment and treatment adherence in elderly hypertensive patients. Clin Interv Aging. 2018; 13: 1409–1418. https://doi.org/10.2147/CIA.S1....
 
48.
Walker KA, Power MC, Gottesman RF. Defining the Relationship Between Hypertension, Cognitive Decline, and Dementia: a Review. Curr Hypertens Rep. 2017; 19(3): 24. https://doi.org/10.1007/s11906... 0724-3.
 
49.
Yuenyongchaiwat K, Baker I, Maratos F, et al. Do Cardiovascular Responses to Active and Passive Coping Tasks predict Future Blood Pressure over a 10-Month Later? Span J Psychol. 2016; 14: 10. https://doi.org/10.1017/sjp.20....
 
50.
Li T, Bai Y, Xiang J, et al. Duration of hypertension is associated with cognitive function: a cross-sectional study in Chinese adults. Chin Med J. 2014; 127(11): 2105–10.
 
51.
Vyas S, Rodrigues AJ, Silva JM, et al. Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration. Neural Plast. 2016; 2016: 6391686. https://doi.org/10.1155/2016/6....
 
52.
Uiterwijk R, Huijts M, Staals J, et al. Subjective Cognitive Failures in Patients With Hypertension Are Related to Cognitive Performance Urszula Łopuszańska, Krystian Cholewa, Magdalena Kozyra. Cognitive consequences of metabolic disordersand Cerebral Microbleeds. Hypertension. 2014: 64(3): 653–7. https://doi.org/10.1161/HYPERT....
 
53.
Fiford CM, Nicholas JM, Biessels GJ, et al. High blood pressure predicts hippocampal atrophy rate in cognitively impaired elders. Alzheimers Dement (Amst). 2020; 12(1): e12035. https://doi.org/10.1002/dad2.1....
 
54.
Shinohara M, Sato N, Shimamura M, et al. Possible modification of Alzheimer’s disease by statins in midlife: interactions with genetic and non-genetic risk factors. Front Aging Neurosci. 2014; 23(6): 71. https://doi.org/10.3389/fnagi.....
 
55.
Chen ST, Siddarth P, Ercoli LMet al. Modifiable Risk Factors for Alzheimer Disease and Subjective Memory Impairment across Age Groups. PLoS One. 2014; 9(6): e98630. https://doi.org/10.1371/journa....
 
56.
Forte G, De Pascalis V, Favieri F, Casagrande M. Effects of Blood Pressure on Cognitive Performance: A Systematic Review. J Clin Med. 2019; 9(1): 34. https://doi.org/10.3390/jcm901....
 
57.
Rochlani Y, Pothineni NV, Kovelamudi S, et al. Metabolic syndrome: pathophysiology, management, and modulation by natural compounds. Ther Adv Cardiovasc Dis. 2017; 11(8): 215–225. https://doi.org/10.1177/175394....
 
58.
Yates KF, Sweat V, Lai YP, et al. Impact of Metabolic Syndrome on Cognition and Brain: A Selected Review of the Literature. Arterioscler Thromb Vasc Biol. 2012; 32(9): 2060–2067. https://doi.org/10.1161/ATVBAH....
 
59.
Cavalieri M, Ropele S, Petrovic K, et al. Metabolic Syndrome, Brain Magnetic Resonance Imaging, and Cognition. Diabetes Care. 2010; 33(12): 2489–2495. https://doi.org/10.2337/dc10-0....
 
60.
Exalto LG, van der Flier WM, van Boheemen CJ, et al. The metabolic syndrome in a memory clinic population: relation with clinical profile and prognosis. J Neurol Sci. 2015; 351(1–2): 18–23. https://doi.org/10.1016/j.jns.....
 
61.
Levin BE, Llabre MM, Dong C, et al. Modeling metabolic syndrome and its association with cognition: the Northern Manhattan study. J Int Neuropsychol Soc. 2014: 20(10): 951–60. https://doi.org/10.1017/S13556....
 
62.
Yaffe K, Vittinghoff E, Pletcher MJ, et al. Early adult to midlife cardiovascular risk factors and cognitive function. Circulation. 2014; 129(15): 1560–7. https://doi.org/10.1161/CIRCUL....
 
63.
Mehra A, Suri V, Kumari S, et al. Association of mild cognitive impairment and metabolic syndrome in patients with hypertension. Asian J Psychiatr. 2020; 30; 53: 102185. https://doi.org/10.1016/j.ajp.....
 
64.
Bajerska J, Wozniewicz M, Suwalska A, et al. Eating patterns are associated with cognitive function in the elderly at risk of metabolic syndrome from rural areas. Eur Rev Med Pharmacol Sci. 2014; 18(21): 3234–45.
 
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