10
MNiSW
71.22
ICV
RESEARCH PAPER
 
CC BY-NC 3.0 Unported
 
 

Antidepressant activity of ethanolic extract of oleo gum resins of Ferula asafoetida Linn

T Bharath Kumar 1  ,  
R Rushendran 1,  
T Mamatha 1,  
J Roja 1,  
 
1
Department of Pharmacology, Krishna teja pharmacy college, Tirupati, Andhra Pradesh, India
2
Professor, HOD, Department of Pharmacology, Krishna teja pharmacy college, Tirupati, Andhra Pradesh, India
3
Department of Pharmacognosy, Sree Vidyanikethan Pharmacy College, Tirupati, Andhra Pradesh, India
JPCCR 2017;11(1):50–60
KEYWORDS:
ABSTRACT:
Objective:
The study was undertaken to evaluate the antidepressant activity of ethanolic extract of Ferula asafoetida oleo gum resins.

Material and Methods:
Five groups of rats (180–200g) and mice (20–30g) of both genders, each group comprising six animals, were used (i.e., normal, positive control, standard, FAEE 200mg/kg, and FAEE 400mg/kg treated groups). Forced swimming test (FST), Tail suspension test (TST), Potentiation of Norepinephrine-Induced Toxicity (PNEIT), Haloperidol- Induced Catalepsy(HIC), and Reserpine-Induced Hypothermia (RIH), were used as the validate models of depression in rodents. The study was confirmed by brain monoamines estimation (i.e. Dopamine, Norepinephrine and 5-HT), MAO levels and invivo antioxidant studies (CAT and SOD).

Results:
FAEE treated animals showed a significant and dose dependent effect on a decrease in immobility time in FST, TST, and decrease in catalepsy time in HIC. FAEE and imipramine (15mg/kg) showed a significant increase in body temperature in RIH, and also showed a potent lethaltiy in PNEIT. FAEE treated animals showed a significant increase in the level of brain monoamies, in vivo antioxidants, and a significant decrease in MAO levels.

Conclusions:
Results of present study indicate that FAEE has potent antidepressant-like activity, and this effect may be due to the anti-oxidant property of Ferulic acid and umbellifedrone, or may be due to neuroprotective activity of other major phytoconstituent, e.g. flavonoids, phenolic acids and polysulfide compounds. To identifiy the particular compound responsible for the antidepressant-like activity required further molecular level studies

CORRESPONDING AUTHOR:
T Bharath Kumar   
Department of Pharmacology, Krishna teja pharmacy college
 
REFERENCES:
1. Sudhakar Pemminati, Gopalakrishna H.N, Ashok K Shenoy, Sudhanshu Sekhar Sahu, Shishir Mishra, Vinayak Meti, Nair Vinod. Antidepressant activity of aqueous extract of fruits of Emblicaofficinalis in mice. International Journal of Applied Biology and Pharmaceutical Technology 2010; 1(2): 449–454.
2. Ravindra C. Sutar, Sanjay B. Kasture, V.K. Kalaichelvan. Evaluation of antidepressant activity of leaf extracts of Holoptelea integrifolia (roxb) plant in experimental animals. Int J Pharm Pharm Sci. 2014; 6(6): 250–253.
3. Ginpreet Kaur, Mihir Invally, Resham Sanzagiri, Harpal S. Buttar. Evaluation of the antidepressant activity of Moringa oleifera alone and in combination with Fluoxetine. Journal of Ayurveda & Integrative Medicine 2015; 6(4): 273–279.
4. Saldanha D, Kaspate, B. Karmarkar, K. Shah, S. Narkhede. Evaluation of antidepressant activity of ethanolic extract momordica charantia unripen fruit. International Journal of Pharmaceutical Sciences and Drug Research 2015; 7(1): 68–71.
5. Arvind Agarwal, Deepika Bora, Chanderpriya Agarwal, Ratendra Kumar and Veermaram Choudhary. CNS stimulant and antidepressant activity of seeds of Abelmoschus esculentus in rats. Bull Pharm Res. 2015; 5(2): 1–4.
6. Santosh P, Venugopl R, Nilakash AS, Kunjbihari S, Dr. Mangala L. Antidepressant Activity of methanolic extract of Passiflora foetida leaves in mice. International Journal of Pharmacy and Pharmaceutical Sciences 2011; 3(1): 112–115.
7. Mishra Swati, Jena Monalisa, Pal Abhisek. Evaluation of antidepressant activity of Eclipta alba using animal models. Asian J Pharm Clin Res. 2013; 6(3): 118–120.
8. Porsolt RD, Anton G, Blavet N, Jalfre M. Behavioral despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol. 1978; 47: 379–381.
9. Saldanha, D Kaspate, B Karmarkar, K Shah, S Narkhede. Evaluation of antidepressant activity of ethanolic extract momordica charantia unripen fruit. International Journal of Pharmaceutical Sciences and Drug Research 2015; 7(1): 68–71.
10. Steru L, Chermat R, Thierry B, Simon P. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl). 1985; 85: 367–70.
11. Jamwal Neetu Singh, Kumar Sunil, Rana A.C. Antidepressant activity of methanolic extract of Foeniculum vulgare (Fennel) fruits in experimental animal models. Journal of Applied Pharmaceutical Science 2013; 3(9): 65–70.
12. Pamminati, V. Nair, P. Dorababu, H.N. Gopala Krishna, M.R.S.M. Pai. Effect of ethanolic leaf extract of Ocimum sanctum on haloperidol induced catalepsy in albino mice. Inidian jorunal of pharmacology 2013; 39(2): 87–89.
13. Parle Milind and Gurditta. Papita Fruit: A Delicious Remedy for Depression. IJRAP. 2011; 2 (4): 1358–1364.
14. H.Grehard Vogel. Drug discovery and evalution. second eition, Springer 2012.
15. Sigg FB. Pharmacological studies with Tofranil. Canadian Psychiat A J. 1959; 4: 575.
16. Habibur Rahman, M.C Eswaraiah, Simple spectroscopic Methods for estimating Brain Neurotransmitters, Antioxidant Enzymes of Laboratory animals like Mice: A review. Pharmatutor Art. 1244, 2008.
17. Ajit Kumar Thakur, Shyam Sunder Chatterjee and Vikas Kumar. Antidepressant-like activity of Andrographis paniculata in type-2 diabetic rats. Clinical Pharmacology and Biopharmaceutics 2014; S2: 2–9.
18. Shao-Xiao Yan, Jun-Lian Lang, Yan-Ying Song, Yu-Ze Wu, Meng-Han Lv, Xia Zhao, Yan-Hong Liu and Chun-Yan Xu. Studies on anti-depressant activity of four flavonoids isolated from Apocynum venetum linn (apocynaceae) leaf in mice. Tropical Journal of Pharmaceutical Research 2015; 14(12): 2269–2277.
19. Dharani Prasad, V. Ravi chandiran, K. Pavan Kumar, S. Kavimani and V. Suba. Pharmacological Evidences for The Antiamnesic Effect of Dalbergia Latifoia Roxb in Mice. IJPCBS. 2013; 3(3): 955–961.
20. Claiborne JY, Malinowski DP, Fridovich I. “Purification and characterization of hydroperoxidase II of Escherichia coli B”. J Biol Chem. 1979; 254(22): 11664–11668.
21. Mishra HP, Fridovich I. “The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase”. J BiolChem 1972; 247: 3170–3175.
22. Bancroft JD, Gamble M. Theory and Practice of Histological Techniques. Churchill Livingstone, 5th Edition. Harcourt Publisher Limited, London 2002, 153.
23. Farshad Homayouni Moghadam, Maryam Dehghan, Ehsan Zarepur, Reyhaneh Dehlavi, Fatemeh Ghaseminia, Shima Ehsani, Golnaz Mohammadzadeh, Kazem Barzega. Oleo gum resins of Ferula assa-foetida L. ameliorates peripheral neuropathy in mice. Journal of ethnopharmacology 2014; 154(1): 183–189.
24. Arshiya Sultana, Asma K, Khaleequr Rahman and Shafeequr Rahman. Oleo-gum-resins of Ferula asafoetida: A traditional culinary spice with versatile pharmacological activities. Research Journal of Recent Sciences 2015; 4: 16–22.
25. Santosh P, Venugopl R, Nilakash A S, Kunjbihari S, Dr. Mangala L. Antidepressant Activity of methanolic extract of Passiflora foetida leaves in mice. International Journal of Pharmacy and Pharmaceutical Sciences 2011; 3(1): 112–115.
26. Saldanha, D. Kaspate, B. Karmarkar, K. Shah, S. Narkhede. Evaluation of antidepressant activity of ethanolic extract momordica charantia unripen fruit. International Journal of Pharmaceutical Sciences and Drug Research 2015; 7(1): 68–71.
27. Parle Milind and Gurditta. Papita Fruit: A Delicious Remedy for Depression. IJRAP. 2011; 2(4): 1358–1364.
28. Singh G. K. And Kumar V. Neuropharmacological screeningand lack of antidepressant activity of Standardized extract of Fumaria indica. Electronic Journal of Pharmacology and Therapy 2010; 3: 19–28.
29. H.Grehard Vogel. Drug discovery and evalution, second eition, Springer 2012.
30. Warner DS, Sheng H, Batinić-Haberle I. Oxidants, antioxidants and the ischemic brain. J Exp Biol. 2004; 207: 3221–3231.
31. Kareparamban, PH Nikam, AP Jadhav, VJ Kadam. Ferula foetida “Hing”: A Review. 2012 RJPBCS. 2012; 3(2): 775–786.
32. Farshad Homayouni Moghadam, Behzad Vakili Zarch, Mohammad Shafie. Double edged effect of gum-resins of ferula assa-foetida on lifespan of neurons. Iranian journal of basic medical sciences 2013; 16(4): 660.
Copy url
Share
 
 
eISSN:1898-7516
ISSN:1898-2395