Anti-tubercular substances produced by plants
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Institut of Rural Health in Lublin
Department of Medical Biology and Translational Research, Faculty of Medicine, University of Information Technologyn and Management, Rzeszów, Poland
Żaneta Polak   

Institut of Rural Health in Lublin, Jaczewskiego 2, 20-090 Lublin, Poland
J Pre Clin Clin Res. 2017;11(2):147–152
Tuberculosis is one of the common causes of death worldwide, and according to the World Health Organization, in 2015, about 10.4 mln people globally is suffering from that disease. Despite great development in medicine and discovery of many antimycobacterial drugs, tuberculosis remains an unsolved problem. The populations of countries in Africa, Asia and South America have difficult access to hygiene, medical care and medicines, and they therefore resort to consulting traditional practitioners who mainly use drugs from natural sources which they prepare themselves. Plants are the biggest source of such medicines and are used as extracts, decoctions or powders, often without any evidence of their actual activity. Isolates from plants sometimes contain unknown substances or some second metabolites of microorganisms. In vitro studies have shown that some of these medicines have effective antimycobacterial properties, even against clinical, resistant strains. This is hopeful in the situation where more and more cases of tuberculosis prove to be resistant to standard drugs. Extracts of medicinal plants are often synergistic with synthetic drugs. Substances with insufficient MIC can be a basis for derivatives which have better properties. This thesis summarizes the current international knowledge of the use of plant substances used in the treatment of tuberculosis that could be potential new antituberculous drugs.
G. Virella. Mikrobiologia i choroby zakaźne. Wyd.1. Urban&Partner. 1999. p.191-199.
WHO. Global tuberculosis report 2016.
K. Kruczak, E. Niżankowska-Mogilnicka. Gruźlica wielolekooporna – współczesne problemy. Pneumonol. Alergol, Pol. 2009. nr 77. p. 276-283.
CDC. Extensively Drug-Resistant Tuberculosis – United States. 1993-2006.
J. R.S. Tabuti, C. B. Kukunda, P. J. Waako Medicinal plants used by traditional medicine practitioners in the treatment of tuberculosis and related ailments in Uganda.. Journal of Ethnopharmacology. 2010; 127: 130–136.
B. G. Elkington, K. Sydara, A. Newsome, C. Hwa Hwang, D.C. Lankin, C. Simmler, et al. New finding ofananti-TBcompoundinthegenus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos. Journal of Ethnopharmacology. 2014. 151: 903–911.
S. B. Sanusi, M. Fadzelly A.Bakar, M. Mohamed, S. F. Sabran, M. M. Mainasara. Southeast Asian Medicinal Plants as a Potential Source of Antituberculosis Agent. Evidence-Based Complementary and Alternative Medicine. 2017.
R. Gomez-Cansino, S.L. Guzman-Gutierrez, M. G. Campos-Lara, C. I. Espitia-Pinzon, R. Reyes-Chilpa. Natural Compounds from Mexican Medicinal Plants as Potential Drug Leads for Anti-Tuberculosis Drugs. An. Acad. Bras. Ciênc. 2017. 89(1):31-43.
S. B. Lirio, A.P. G. Macabeo, E. M. Paragasb, M. Knornc, P. Kohls, S. G. Franzblau, et al. Antitubercular constituents from Premna odorata Blanco. Journal of Ethnopharmacology 2014. 154(2):471-4.
M. A. Tan, H. Takayama, N. Aimi, M. Kitajima, S. G. Franzblau, M. G. Nonato. Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis. J Nat Med. 2008. 62: 232–235.
A. P. G. Macabeo, F. A Tudla, K. Krohn, S. G Franzblau. Antitubercular activity of the semi-polar extractives of Uvaria rufa. Asian Pacific Journal of Tropical Medicine. 2012. 5(10):777-780.
YC Chien, CH Lin, M. Y. Chiang, HS Chang, CH Liao, IS Chen et al.. Secondary metabolites from the root of Ehretia longiflora and their biological activities. Phytochemistry. 2012. 80:50–57.
H. Seo, S. Kim, H. Al Mahmud, M. I. Islam, KW Nam, BE Lee et al. In vitro Antitubercular Activity of 3- Deoxysappanchalcone Isolated From the Heartwood of Caesalpinia sappan Linn. Phytother. Res. 2017. 31(10):1600-1606.
W. S. Jang, M. A. Jyoti, S. Kim, KW Nam, T. K. Quy Ha, W. K. Oh et al. In vitro antituberculosis activity of diterpenoids from the Vietnamese medicinal plant Croton tonkinensis. J Nat Med. 2016. 70(1):127-32.
M. Bhatnagar, N. Sarkar, N. Gandharv , O. Apang, S. Singh, S. Ghosal. Evaluation of antimycobacterial, leishmanicidal and antibacterial activity of three medicinal orchids of Arunachal Pradesh, India. BMC Complementary and Alternative Medicine. 2017. 17(1):379.
Sanna G, Madeddu S, Giliberti G, Ntalli NG, Cottiglia F, De Logu A, et al. (2015) Limonoids from Melia azedarach Fruits as Inhibitors of Flaviviruses and Mycobacterium tubercolosis. PLoS ONE. 2015. 10(10):e0141272.
LFN Trevizana, K F do Nascimentoa, JA Santosb, CA L Kassuyab, CAL Cardosoc, MD C. Vieira et al. Anti-inflammatory, antioxidant and anti-Mycobacterium tuberculosis activity of viridiflorol: the major constituent of Allophylus edulis (A. St.-Hil., A. Juss. & Cambess.) Radlk. Journal of Ethnopharmacology, 2016. 192:510-515.
D. Dey, R. Ray, B. Hazra. Antitubercular and Antibacterial Activity of Quinonoid Natural Products Against Multi-Drug Resistant Clinical Isolates. Phytother. Res. 2014. 28(7):1014-21.
KF do Nascimento, FMF Moreira, JA Santos, CAL Kassuya, JHR Croda, CAL Cardoso et al. Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol, Journal of Ethnopharmacology. 2018. 10;210:351-358.
RB Ishikawa, MM Leitão, RM Kassuya, LF Macorini, FMF Moreira, CAL Cardoso et al. Anti-inflammatory, antimycobacterial and genotoxic evaluation of Doliocarpus dentatus, Journal of Ethnopharmacology. 2017. 204:18-25.
GM Molina-Salinas, J Bórquez, S Said-Fernández, LA Loyola, A Yam-Puc, P Becerril-Montes, et al. Antituberculosis activity of alkylated mulinane diterpenoids. Fitoterapia. 2010. 81(3):219–222.
TE O’Neill, H Li,a CD Colquhoun, JA Johnson, D Webster, CA Gray. Optimisation of the Microplate Resazurin Assay for Screening and Bioassay-guided Fractionation of Phytochemical Extracts against Mycobacterium tuberculosis. Phytochemical Anal. 2014. 25(5):461–467.
H Hussain, J Hussain, A Al-Harrasi, IR Green. Chemistry and biology of the genus Voacanga. Pharmaceutical Biology. 2012. 50(9): 1183–1193.
N.I. Mongalo, L.J. McGaw, T.V. Segapelo, J.F. Finnie and J. Van Staden, Ethnobotany, Phytochemistry, Toxicology and Pharmacological properties of Terminalia sericea Burch. ex DC. (Combretaceae)- A review, Journal of Ethnopharmacology. 2016. 194:789-802.
BS.Siddiqui, HA.Bhatti, S Begum, S Perwaiz. Evaluation of the antimycobacterium activity of the constituents from Ocimum basilicum against Mycobacterium tuberculosis. J.Ethnopharmacol. 2012. 144 (1): 220–222.
SS Nair, SS. Gaikwad, SP Kulkarni, AP Mukne. Allium sativum Constituents Exhibit Anti-tubercular Activity In vitro and in RAW 264.7 Mouse Macrophage Cells Infected with Mycobacterium tuberculosis H37Rv. Pharmacogn Mag. 2017. 13(Suppl 2): S209–S215.
C Oosthuizen, M Arbach, D Meyer, C Hamilton, N Lall. Diallyl Polysulfides from Allium sativum as Immunomodulators, Hepatoprotectors, and Antimycobacterial Agents. J Med Food. 2017. 20(7):685-690.
Y Zheng, X Jiang, F Gao, J Song, J Sun, L Wang, et al. Identification of plant-derived natural products as potential inhibitors of the Mycobacterium tuberculosis proteasome. BMC Complement. Altern. Med. 2014, 14:400.
T Askun, E M Tekwu, F Satil, S Modanlioglu, H Aydeniz. Preliminary antimycobacterial study on selected Turkish plants (Lamiaceae) against Mycobacterium tuberculosis and search for some phenolic constituents. BMC Complement. Altern. Med. 2013. 13:365.
S Ullah, S Hussain, SN Khan, M Khurram, I Khan, MA Khan. The medicinal plants in the control of tuberculosis: Laboratory study on medicinal plants from the Northern Area of Pakistan. Int J Mycobacteriol 2017. 6(1):102-5.
HT Kuo, CF Peng, HY Huang, CH Lin, IS Chen, IL Tsai. Chemical Constituents and Antitubercular Activity of Formosan Pisonia umbellifera.. Planta. Med. 2011. 77(7): 736–741.
J Spavieri, M Kaiser, R Casey, S Hingley-Wilson, A Lalvani, G Blunden et al. Antiprotozoal, Antimycobacterial and Cytotoxic Potential of Some British Green Algae. Phytother. Res.2010. 24(7): 1095–1098.
HY Huang, T Ishikawa, CF Peng, S Chen, IS Chen. Secondary Metabolites from the Root Wood of Zanthoxylum wutaiense and Their Antitubercular Activity. Chem. Biodivers.2011. 8(5):880-6.
Ampicillin identification. DrugBank. (24.10.2017).
YF Guan, X Song, MH Qiu, SH Luo, BJ Wang, NV Hung et al. Bioassay-Guided Isolation and Structural Modification of the Anti-TB Resorcinols from Ardisia gigantifolia.. Chem. Biol. Drug Des 2016. 88(2):293-301.
V.O. Fadipe, N. I. Mongal, A.R. Opoku, P. M. Dikhoba. T. J. Makhafola. Isolation of anti-mycobacterial compounds from Curtisia dentata (Burm.f.) C.A.Sm (Curtisiaceae). BMC Complement. Altern. Med. 2017. 17:306.
H Yuan, R He, B Wan, Y Wang, GF Pauli, SG Franzblau, AP Kozikowski. Modification of the side chain of micromolide, an anti-tuberculosis natural product. Bioorg. Med. Chem. Lett. 2008. 18 (19):5311–5315.
J Perez-Meseguer, E del Olmo, B Alanis-Garza, R Escarcena, E Garza-González, R Salazar-Aranda et al. Synthesis of Leubethanol derivatives and evaluation against Mycobacterium tuberculosis. Bioorg. Med. Chem. 2012 20 (13):4155–4163.
P Mutai, E Pavadai, I Wiid, A Ngwane, B Baker, K Chibale, Synthesis, Antimycobacterial evaluation and pharmacophore modeling of analogues of the natural product formononetin. Bioorg. Med. Chem. Lett. 2015. 25(12):2510-3.
YL Chen, ST Huang, FM Sun, YL Chiang, CJ Chiang, CM Tsai et al. Transformation of cinnamic acid from trans- to cis-form raises a notable bactericidal and synergistic activity against multiple-drug resistant Mycobacterium tuberculosis. Eur. J. Pharm. Sci. 2011. 43 (3):188–194.
S Warit, K Rukseree, T Prammananan, P Hongmanee, P Billamas, S Jaitrong et al. In Vitro Activities of Enantiopure and Racemic 1 0 -Acetoxychavicol Acetate against Clinical Isolates of Mycobacterium tuberculosis.. Sci. Pharm. 2017. 85: 32.
C Mei, BS Flinn. The Use of Beneficial Microbial Endophytes for Plant Biomass and Stress Tolerance Improvement. Recent Pat. on Biotechno. 2010, 4(1):81-95.
A Alvin, KI Miller, BA Neilan. Exploring the Potential of Endophytes from 1 Medicinal Plants as Sources of Antimycobacterial Compounds. Microbiol. Res. 2014. 169(7-8):483-95.
AY Gordien, AI Gray, K Ingleby, SG Franzblau, V Seidel. Activity of Scottish Plant, Lichen and Fungal Endophyte Extracts against Mycobacterium aurum and Mycobacterium tuberculosis, Phytother. Res. 2010. 24(5):692–698.
A Shah, MA Rather, QP Hassan, MA Aga, S Mushtaq, AM Shah et al. Discovery of anti-microbial and anti-tubercular molecules from Fusarium solani: an endophyte of Glycyrrhiza glabra.. J. Appl. Microbiol. 2017. 122(5):1168-1176.
JH Pan, Y Chen, YH Huang, YW Tao, J Wang, Y Li et al. Antimycobacterial Activity of Fusaric Acid from a Mangrove Endophyte and its Metal Complexes. Arch Pharm Res.2011. 34(7): 1177-1181.
KW Nam, WS Jang, MA Jyoti, S Kim, BE Lee, HY Song. In vitro activity of (-)-deoxypergularinine, on its own and in combination with anti-tubercular drugs, against resistant strains of Mycobacterium tuberculosis. Phytomedicine. 2016. 23(5):578-82.
PN Fauziyah, EY Sukandar, DK Ayuningtyas. Combination Effect of Antituberculosis Drugs and Ethanolic Extract of Selected Medicinal Plants against Multi-Drug Resistant Mycobacterium tuberculosis Isolates. Sci. Pharm. 2017. 85(1):14.