CASE REPORT
Three interesting cases of syndrome of inappropriate antidiuretic hormone secretion
 
More details
Hide details
1
Chair and Department of Internal Diseases, Medical University of Lublin, Poland
2
Chair and Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, Poland
3
The Scientific Society of Students at the Department of Internal Diseases, Medical University of Lublin, Poland
4
Chair and Departament of Internal Diseases, Medical University of Lublin, Poland
CORRESPONDING AUTHOR
Anna Grzywa-Celińska   

Chair and Department of Pneumonology, Oncology and Allergology, Medical University, Lublin, Staszica 16, 20-081 Lublin, Poland
 
J Pre Clin Clin Res. 2015;9(2):174–176
KEYWORDS
ABSTRACT
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is an etiologically-diverse pathological condition resulting from the elevation in both ectopic and autonomic secretion of the antidiuretic hormone (ADH) by neoplastic tissue; excessive stimulation of the hypothalamic-pituitary axis, e.g. in pulmonary diseases, central nervous system (CNS) abnormalities, endocrine glands dysfunction or due to the use of some medications; intensification of renal ADH action by certain medications and action of substances chemically-related to vasopressin. The clinical characteristics of the syndrome are comprised of the presence of inadequately concentrated urine, hyponatremia, and hypo-osmolal blood serum, as well as weight gain. To show the variety of its causes and courses the article presents three cases of patients diagnosed with SIADH in the Department of Internal Medicine. In each of them the syndrome of inappropriate antidiuretic hormone secretion manifested in clinical laboratory tests in the form of hyponatremia.
 
REFERENCES (16)
1.
Platania M, Verzoni E, Viali M. Hyponatremia in cancer patients. Tumori. 2015; 28: 101(2): 246–8.
 
2.
Grohe C, Berardi R, Burst V. Hyponatraemia – SIADH in lung cancer diagnostic and treatment algorithms. Crit Rev Oncol Hematol. 2015; (Epub ahead to print).
 
3.
Karczmarek-Borowska B, Zielińska K, Bukała A. Hyponatremia in the course of small cell lung cancer-a case repor. Pol Merk Lek. 2014; 37(217): 49–52.
 
4.
Amoako AO, Brown C, Ruley T. Syndrome of inappropriate antidiuretic hormone secretion: a story of duloxetine – induced hyponatraemia, BMJ Case Rep. 2015: 24.
 
5.
Lange-Asschenfeldt C, Kojda G, Cordes J, Hellen F, Gillmann A, Grohmann R, et al. Epidemiology, symptoms, and treatment characteristics of hyponatremic psychiatric inpatients. J Clin Psychopharmacol. 2013; 33(6): 799–805.
 
6.
Padhi R, Panda BN, Jagati S, Patra SC. Hyponatremia in critically ill patients. Indian J Crit Care Med. 2014; 18(2): 83–87.
 
7.
Zgliczyński S. Nadmierne wydzielanie hormonu antydiuretycznego – zespół Schwartz-Barttera. PAMW 1971; 47: 555–561 (in Polish).
 
8.
Olsson K, Öhlin B, Melander O. Epidemiology and characteristics of hyponatremia in the emergency department. Eur J Intern Med. 2013; 24(2): 110–116.
 
9.
Krysiak R, Okopień B. Zespół nieadekwatnego wydzielania wazopresyny, Przegl Lek. 2014; 71(5): 277–285 (in Polish).
 
10.
Witek P. Postępy w rozpoznawaniu i leczeniu hiponatremii. Postepy Nauk Med. 2008; 2: 75–82 (in Polish).
 
11.
Hoorn EJ, van der Lubbe N, Zietse R. SIADH and hyponatraemia: why does it matter? NDT Plus. 2009; 2 [Suppl 3]: iii5–iii11.
 
12.
Hannon MJ, Thompson CJ. The syndrome of inappropriate antidiuretic hormone: prevalence, causes and consequences. Eur J Endocrinol. 2010; 162: 5–12.
 
13.
Zhang YZ, Qie JY, Zhang QH. Incidence and mortality prognosis of dysnatremias in neurologic critically ill patients. Eur Neurol. 2015; 73(1–2): 29–36.
 
14.
Saleem S, Yousuf I, Gul A, Gupta S, Verma S. Hyponatremia in stroke. Ann Indian Acad Neurol. 2014; 17(1): 55–7.
 
15.
Funk GC, Lindner G, Druml W, Metnitz B, Schwarz C, Bauer P, Metnitz PG. Incidence and prognosis of dysnatremias present on ICU admission. Intensive Care Med. 2010; 36(2): 304–11.
 
16.
Basu A, Ryder RE. The syndrome of inappropriate antidiuresis is associated with excess long-term mortality: a retrospective cohort analyses. J Clin Pathol. 2014; 67(9): 802–6.
 
eISSN:1898-7516
ISSN:1898-2395