CASE REPORT
Severe hyponatremia due to inappropriate antidiuretic hormone secretion – a case report
 
More details
Hide details
1
Department of Internal Medicine, Medical University, Lublin, Poland
CORRESPONDING AUTHOR
Andrzej Prystupa   

Department of Internal Medicine, Medical University, Staszica 16, 20-081 Lublin, Poland.
 
J Pre Clin Clin Res. 2012;6(1):61–63
KEYWORDS
ABSTRACT
Inappropriate antidiuretic hormone secretion syndrome (SIADH) is the most common cause of normovolemic hypotonic hyponatremia in hospital settings. The article describes the case of a female patient admitted to hospital because of life threatening hyponatremia, probably due to SIADH. Laboratory tests and imaging were made to exclude possible causes of inadequate ADH release. 3% saline infusion together with dietary salt supplementation and fluid restriction were applied to restore sodium balance. The patient was successfully treated and discharged home without evident neurological deficits.
 
REFERENCES (13)
1.
Upadhyay A, Jaber BL, Madias NE. Incidence and prevalence of hyponatremia. Am J Med. 2006; 119(7 Suppl 1): S30-5.
 
2.
Patel GP, Balk RA. Recognition and treatment of hyponatremia in acutely ill hospitalized patients. Clin Ther. 2007; 29(2): 211-29.
 
3.
Thompson C, Hoorn EJ. Hyponatraemia: an overview of frequency, clinical presentation and complications. Best Pract Res Clin Endocrinol Metab. 2012; 26 Suppl 1: S1-6.
 
4.
Thompson C, Berl T, Tejedor A, Johannsson. Differential diagnosis of hyponatremia. Best Pract Res Clin Endocrinol Metab. 2012; 26 Suppl 1: S7-15.
 
5.
Vu T, Wong R Fracp, Hamblin PS, Zajac J Fracp, Grossman M Fracp. Patients Presenting with Severe Hypotonic Hyponatremia: Etiological Factors, Assessment, and Outcomes. Hosp Pract. (Minneap) 2009; 37(1): 128-136.
 
6.
Baylis PH. The syndrome of inappropriate antidiuretic hormone secretion. Int J Biochem Cell Biol. 2003; 35(11): 1495-9.
 
7.
Pillai BP, Unnikrishnan AG, Pavithran PV. Syndrome of inappropriate antidiuretic hormone secretion: Revisiting a classical endocrine disorder. Indian J Endocrinol Metab. 2011; 15 Suppl 3: S208-15.
 
8.
Siragy HM. Hyponatremia, fluid-electrolyte disorders, and the syndrome of inappropriate antidiuretic hormone secretion: diagnosis and treatment options. Endocr Pract. 2006; 12(4): 446-57.
 
9.
Peri A, Combe C. Considerations regarding the management of hyponatremia secondary to SIADH. Best Pract Res Clin Endocrinol Metab. 2012; 26 Suppl 1: S16-26.
 
10.
Hwang SB, Lee HY, Kim HY, Less ES, Bae JW. Life-threatening acute hyponatremia with generalized seizure induced by low-dose cyclophosphamide in a patient with breast cancer. J Breast Cancer. 2011; 14(4): 345-8.
 
11.
Umadevi V, Rajesh J, Kumar SS, Shakir RM, Vijayashankar C, Prasad CV. Deep vein thrombosis and euvolemic hyponatremia in a hypothyroid patient. J Assoc Physicians India. 2011; 59: 740-1.
 
12.
Khanna A, Menon MC. The use of vasopressin receptor antagonists in hyponatremia. Curr Opin Investig Drugs. 2010; 11(9): 1007-14.
 
13.
Ghali JK, Tam SW. The critical link of hypervolemia and hyponatremia in heart failure and the potential role of arginine vasopressin antagonist. J Card Fail. 2010; 16(5): 419-31.
 
eISSN:1898-7516
ISSN:1898-2395