Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumour of the gastrointestinal tract. Liver metastasis and diffuse intraabdominal spread are typical manifestation of advanced malignancy. A 59-year-old female patient was admitted to the Internal Department with synchronous liver metastases. Clinical examination revealed a palpable abdominal mass in the left epigastrum. Gastroscopy examination revealed an advanced neoplasmatical tumour of the stomach. The histological findings showed GIST with strong CD117 and CD34 reactivity. GIST was characterised by oncogenic mutations of the KIT receptor tyrosine kinase. Imatinib (tyrosine kinase inhibitor) was used in the treatment of metastatic GIST.
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