RESEARCH PAPER
Influence of prolonged manganese intoxication on memory processes in hypoxic mice
 
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1
Department of Physiopathology, Institute of Agricultural Medicine, Lublin, Poland
2
Department of Hygiene, Medical University, Lublin, Poland
CORRESPONDING AUTHOR
Krzysztof Łukawski   

Department of Physiopathology, Institute of Agricultural Medicine, Jaczewskiego 2, 20-090 Lublin, Poland.
 
J Pre Clin Clin Res. 2010;4(1):43–46
KEYWORDS
ABSTRACT
Exposure to high levels of manganese in the workplace can result in the development of neurotoxic symptoms in humans. It is also known that exposure to heavy metals, including manganese, can lead to learning and memory deficits. Recently, it has been demonstrated that hypoxic mice in the model of bilateral clamping of the carotid arteries (BCCA) can be more vulnerable to the effects of lead or cadmium. The purpose of the present study was to examine the effect of prolonged manganese intoxication – up to 10 days – on memory processes in mice exposed to transient cerebral oligemic hypoxia induced by 30 min of BCCA. In the current study, long-term memory was evaluated using the step-through passive avoidance task. Spatial working memory was assessed by recording spontaneous alternation in the Y-maze test. In the passive avoidance task, manganese administered at a dose of 7.95 mg/kg i.p. did not impair retention in BCCA mice. Manganese at the same dose of 7.95 mg/kg i.p. did not alter alternation behaviour in the Y-maze either. These findings suggest that hypoxia induced by BCCA combined with prolonged manganese intoxication does not affect memory functions of mice.
 
REFERENCES (29)
1.
Smith MZ, Auer RN, Sjesjo BK: The density and distribution of ischemic brain injury in rats following 2-10 min of forebrain ischemia. Acta Neuropathol 1984, 64, 319-332.
 
2.
Ginsberg MD, Takagi K, Globus MY-T: Release of neurotransmitters in cerebral ischemia: relevance to neuronal injury. In: Krieglstein J, Oberpichler-Schwenk H (Eds.): Pharmacology of cerebral ischemia. Wiss Verl-Ges, Stuttgart, 1992, 177-190.
 
3.
Sontag K-H, Heim C, Block F, Sieklucka M, Schmidt-Kastner R, Melzacka M, Osborne N, Laer S, Huther G, Kunkel M, Ulrich F, Bortolotto Z, Weiner N, Wesemann W: Cerebral oligemic hypoxia and forebrain ischemia-common and diff erent long-lasting consequences. In: Krieglstein J, Oberpichler-Schwenk H (Eds.): Pharmacology of Cerebral Ischemia. Wiss Verl-Ges, Stuttgart, 1992, 471-479.
 
4.
Heim C, Sieklucka M, Block F, Schmidt-Kastner R, Jaspers R, Sontag K-H: Transient occlusion of carotid arteries leads to disturbed spatial learning and memory in the rat. In: Krieglstein J, Oberpichler H (Eds.): Pharmacology of Cerebral Ischemia. Wiss Verl-Ges, Stuttgart, 1990, 53-61.
 
5.
Morris RGM, Garrund P, Rawlins JNP, O’Keefe J: Place navigation impaired in rats with hippocampal lesions. Nature 1982, 297, 681- 683.
 
6.
Block F, Sieklucka M, Schmidt-Kastner R, Heim C, Sontag K-H: Electrophysiological, metabolic and biochemical approaches to the eff ects of bilateral clamping of carotid arteries in normotensive rats. In: Krieglstein J, Oberpichler H (Eds.): Pharmacology of Cerebral Ischemia. Wiss Verl-Ges, Stuttgart, 1990, 47-52.
 
7.
Sieklucka M, Heim C, Block F, Sontag K-H: Transient reduction of cerebral blood fl ow leads to long-lasting increase in GABA content in vulnerable structures and decreased susceptibility to bicuculline induced seizures. J Neural Transm 1992, 88, 87-94.
 
8.
Laer S, Block F, Huther G, Heim C, Sontag K-H: Eff ect of transient reduction of cerebral blood fl ow in normotensive rats on striatal dopamine-release. J Neural Transm (Gen Sect) 1993, 92, 203-211.
 
9.
Heim C, Zhang J, Lan J, Sieklucka M, Kurz T, Riederer P, Gerlach M, Sontag K-H: Cerebral oligaemia episode triggers free radical formation and late cognitive defi ciencies. Eur J Neurosci 2000, 12, 715-725.
 
10.
ATSDR: Toxicological profi le for manganese. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry. Atlanta, Georgia, USA 2008.
 
11.
Dobson AW, Erikson KM, Aschner M: Manganese neurotoxicity. Ann N Y Acad Sci 2004, 1012, 115-128.
 
12.
Guilarte TR, Chen MK: Manganese inhibits NMDA receptor channel function: implications for psychiatric and cognitive eff ects. Neurotoxicology 2007, 28, 1147-1152.
 
13.
Bird ED, Anton AH, Bullock B: The eff ect of manganese inhalation on basal ganglia dopamine concentrations in rhesus monkey Neurotoxicology 1984, 5, 59-65.
 
14.
Shukakidze A, Lazriev I, Mitagvariya N: Behavioral impairments in acute and chronic manganese poisoning in white rats. Neurosci Behav Physiol 2003, 33, 263-267.
 
15.
Łukawski K, Nieradko B, Sieklucka-Dziuba M: Eff ects of cadmium on memory processes in mice exposed to transient cerebral oligemia. Neurotoxicol Teratol 2005, 27, 575-584.
 
16.
Łukawski K, Sieklucka-Dziuba M: Eff ect of lead exposure on memory mprocesses in mice after cerebral oligemia. Pharmacol Rep 2007, 59, 691-698.
 
17.
Sarter M, Bodewitz G, Stephens DN: Attenuation of scopolamineinduced impairment of spontaneous alternation behavior by antagonist but not inverse agonist and agonist β-carbolines. Psychopharmacology 1988, 94, 491-495.
 
18.
Venault P, Chapouthier G, Prado de Carvalho L, Simiand J, Morre M, Dodd RH, Rossier J: Benzodiazepine impairs and β-carboline enhances performance in learning and memory tasks. Nature 1986, 321, 864- 866.
 
19.
Joźwiak L, Sieklucka-Dziuba M, Kleinrok Z: Behavioral studies of the eff ects of moderate oligemic hypoxia caused by bilateral clamping of carotid arteries in mice. Impairment of spatial working memory. Pol J Pharmacol 1998, 50, 279-289.
 
20.
Bortolotto ZA, Heim C, Sieklucka M, Block F, Sontag K-H, Cavalheiro EA: Eff ects of bilateral clamping of carotid arteries on hippocampal kindling in rats. Physiol Behav 1991, 49, 667-671.
 
21.
Joźwiak L, Łukawski K, Czuczwar SJ, Sieklucka-Dziuba M: Competitive NMDA receptor antagonists and agonists: eff ects on spontaneous alternation in mice exposed to cerebral oligemia. Pol J Pharmacol 2004, 56, 59-66.
 
22.
Roth JA, Garrick MD: Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese. Biochem Pharmacol 2003, 66, 1-13.
 
23.
Guilarte TR: Manganese and Parkinson’s disease: a critical review and new fi ndings. Environ Health Perspect 2010, 118, 1071-1080.
 
24.
Roth JA: Are there common biochemical and molecular mechanisms controlling manganism and parkinsonism? Neuromolecular Med 2009, 11, 286-296.
 
25.
Brouillet EP, Shinobu L, McGarvey U, Hochberg F, Beal MF: Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism. Exp Neurol 1993, 120, 89-94.
 
26.
Vezer T, Kurunczi A, Naray M, Papp A, Nagymajtenyi L: Behavioral eff ects of subchronic inorganic manganese exposure in rats. Neurotoxicology 2007, 28, 1147-1152.
 
27.
Heim C, Kolasiewicz W, Sontag K-H: The eff ects of the 21-aminosteroid U-74389 on spatial orientation in rats after a cerebral oligemic episode and iron-induced oxidative stress. J Neural Transm 2000, 107, 95- 104.
 
28.
Nam J, Kim K: Abnormal motor function and the expression of striatal dopamine D2 receptors in manganese-treated mice. Biol Pharm Bull 2008, 31, 1894-1897.
 
29.
Fitsanakis VA, Au C, Erikson KM, Aschner M: The eff ects of manganese on glutamate, dopamine and gamma-aminobutyric acid regulation. Neurochem Int 2006, 48, 426-433.
 
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