Upper cervical spine giant cell tumour of the vertebra – Case Report
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Neurosurgery and Paediatric Neurosurgery Department, Clinical Hospital SPSK4, Lublin, Poland
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Pawel Szmygin   

Neurosurgery and Paediatric Neurosurgery Department, Clinical Hospital SPSK4 in Lublin
J Pre Clin Clin Res. 2016;10(2):133-135
Giant cell tumour (GCT) is a benign aggressive tumour, which affects the axial and peripheral skeleton. Pathological fractures often occur in cases where epiphyses are affected. GCT located in the cervical spine is rare and poses a serious surgical challenge and as far as approach and range of operation is concerned, is subject of debate. We report a case of GCT involving two vertebral bodies, C2 and C3, treated with posterior occipito-cervical junction stabilization, denosumab chemotherapy and transoral corpectomy.
Turcotte RE. Giant cell TUMOUR of bone. Orthop Clin North Am. 2006; 37(1): 35–51.
Eckardt JJ, Grogan TJ. Giant cell tumor of bone. Clin Orthop Relat Res. 1986; 204(2): 45–58.
McGrath PJ. Giant-cell tumour of bone: an analysis of fifty-two cases. J Bone Joint Surg Br. 1972; 54(2): 216–29.
Hart RA, Boriani S, Biagini R, Currier B, Weinstein JN. A system for surgical staging and management of spine tumors. A clinical outcome study of giant cell TUMOURs of the spine. Spine (Phila Pa 1976) 1997; 22: 1773–1782. discussion 1783.
Thomas DM, Skubitz T. Giant-cell tumour of bone. Curr Opin Oncol. 2009; 21: 338–344.
Bertoni F, Present D, Sudanese A, Baldini N, Bacchini P, Campanacci M. Giant-cell tumor of bone with pulmonary metastases. Six case reports and a review of the literature. Clin Orthop Relat Res. 1988; 237(2): 275–85.
Pai SB, Lalitha RM, Prasad K, Rao SG, Harish K. Giant cell tumor of the temporal bone—a case report. BMC Ear Nose Throat Disord. 2005; 5: 8.
Siebenrock KA, Unni KK, Rock MG. Giant-cell tumour of bone metastasising to the lungs. A long-term follow-up. J Bone Joint Surg Br. 1998; 80(1): 43–7.
Werner, M. Giant cell tumour of bone: morphological, biological and histogenetical aspects. Springer-Verlag. 2006; 30: 484–489.
Muheremu A, Niu X. Pulmonary metastasis of giant cell tumor of bones. World J Surg Oncol. 2014; 12: 261.
Lackman RD, Khoury LD, Esmail A, Donthineni-Rao R. The treatment of sacral giant-cell tumours by serial arterial embolisation. J Bone Joint Surg Br. 2002; 84: 873–877.
Hudson T M. Fluid levels in aneurysmal bone cysts: a CT feature. AJR Am J Roentgenol. 1984; 142(5): 1001–1004.
Seon Chun K, Wonik C, Ung-Kyu C, Sang Min Y. Clinical Outcome of Treatment for Patients with Giant Cell Tumor in Spine. J Korean Neurosurg Soc. 2015 Sep; 58(3): 248–253.
Ozaki T, Liljenqvist U, Halm H, Hillmann A, Gosheger G, Winkelmann W. Giant cell tumor of the spine. Clin Orthop Relat Res. 2002; 401: 194–201.
Sanjay BK, Sim FH, Unni KK, McLeod RA, Klassen RA. Giant-cell tumours of the spine. J Bone Joint Surg Br. 1993;75:148–154.
Gille O, Oliveira Bde A, Guerin P, Lepreux S, Richez C, Vital JM. Regression of giant cell tumor of the cervical spine with bisphosphonate as single therapy. Spine (Phila Pa 1976) 2012; 37: E396–E399.
Lee CG, Kim SH, Kim DM, Kim SW. Giant cell tumor of upper thoracic spine. J Korean Neurosurg Soc. 2014; 55: 167–169.
Marcove RC, Lyden JP, Huvos AG, Bullough PB. Giant-cell tumors treated by cryosurgery. A report of twenty-five cases. J Bone Joint Surg Am. 1973; 55: 1633–1644.
Boriani S, Bandiera S, Casadei R, Boriani L, Donthineni R, Gasbarrini A, et al. Giant cell tumor of the mobile spine: A review of 49 cases. Spine (Phila Pa 1976) 2012; 37: E37–45.
Dahlin D C. Giant-cell tumor of vertebrae above the sacrum: a review of 31 cases. Cancer. 1977; 39(3): 1350–1356.
Lopes A A, Cassidy J D, Yong-Hing K. Giant-cell tumour in the cervical spine: a case report. J Can Chiropr Assoc. 1989; 33(22): 76–81.
Santiago N M, Ferreira A, Otta G, et al. Giant cell tumor of the cervical spine: review and case report. Arq Bras Neurocir. 2012; 31(4): 245–248.
Balke M, Schremper L, Gebert C, et al. Giant cell tumor of bone: treatment and outcome of 214 cases. J Cancer Res Clin Oncol. 2008; 134(9): 969–978.
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