The P300 event-related brain potential, relationship with functional, familial and chronic subtypes of alcohol dependence
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Institute of Rural Health, Lublin, Poland
Institute of Physiology and Pathology of Hearing, Warsaw
Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland
College of Humanities and Natural Sciences, Sandomierz, Poland
Corresponding author
Roman Chwedorowicz   

Institute of Rural Health, Lublin, Poland
J Pre Clin Clin Res. 2016;10(2):82-86
The results of contemporary studies confirm that the electrophysiological characteristics of alcoholics, such as low P300 amplitude of the Event-Related Potential (ERP), are related with high risk in their offspring, and are considered to be biological endophenotypes of predisposition to develop alcohol use disorders. The purpose of this study was to evaluate the differences in the theta (4–7 Hz) ERP occurring in the P300 response in the resting EEG of alcoholics in comparison to normal age- and gender-matched control subjects. The study included individuals of Polish ancestry with three generations (parents, siblings, spouses, marrying into the family, and children) from families with a positive diagnosis of alcohol dependence. Next, the group of alcoholics was subdivided into five distinct groups, according to the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The control group consisted of 25 unaffected individuals from families who were screened and assessed to be negative for a diagnosis of alcohol dependence. The theta band (4–7 Hz) visual ERP occurring in the P300 response in the resting EEG were examined to explore the electrophysiological effects of alcohol on the brain in patients with alcohol addiction. The amplitude and latency of auditory P300 response was recorded in the frontal, central, occipital and temporal regions, in control and alcohol dependent individuals. The amplitude of auditory P300 response in the central areas of the brain was lower in alcoholics in all studied groups, compared to the control subjects, except for the young adult subtype. No statistical difference in the amplitude of P300 potential in the studied brain regions was observed between the young adult subtype, and the control group. Similar P300 amplitude values in the young adult subtype and in the controls, and different values in the remaining alcoholics in the study, allow the differentiation into two subtypes of young alcoholics, based on the P300 amplitude as the biological endophenotype, and provide the background related with causative environmental and genetic factors in alcohol addiction.
Dick DM, Agrawal A, Wang JC, et al. Alcohol dependence with comorbid drug dependence: Genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk. Addiction. 2007; 102: 1131–1139.
Bell RL, Hauser S, Rodd ZA, et al. A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. Int Rev Neurobiol. 2016; 126: 179–261.
Devor EJ, Cloniger CR. Genetics of alcoholism. Annu Rev Genet. 1989; 23: 19–36.
Hill SY, O’Brien J. Psychological and neurobiological precursors of alcohol use disorders in high-risk youth. Curr Addict Rep. 2015; 2: 104–113.
Sutton S, Braren M, Zubin J, John E. Evoked potential correlates of stimulus uncertainty. Science. 1965; 150: 1187–1188.
Bauer LO, Hesselbrock VM. P300 decrements in teenagers with conduct problems: implications for substance abuse risk and brain development. Biol Psychiatry. 1999; 46: 264–272.
Handy TC. Event-Related Potentials, A methods Handbook. ed. by Todd C. Handy. Massachusetts Institute of Technology; 2005.
Kropotov JD. Quantitative EEG, Event-Related Potentials and Neurotherapy. Academic Press, San Diego, USA; 2009.
Begleiter H, Porjesz B, Bihari B, Kissin B. Event-related brain potentials in boys at risk for alcoholism. Science. 1984; 225: 1493–1496.
Huang W J, Chen WW, Zhang X. The neurophysiology of P 300 –an integrated review. Eur Rev Med Pharmacol Sci. 2015; 19: 1480–1488.
Euser AS, Arends LR, Evans BE, et al. The P300 event-related brain potential as a neurobiological endophenotype for substance use disorders: a meta-analytic investigation. Neurosci Biobehav Rev. 2012; 36: 572–603.
Dick DM, Jones K, et al. Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism. Behav Gen. 2006; 36: 112 – 126.
Frodl-Bauch T, Bottlender R, Hegerl U. Neurochemical substrates and neuroanatomical generators of the event-related P300. Neuropsychobiology. 1999; 40: 86–94.
Cservenka A. Neurobiological phenotypes associated with a family history of alcoholism. Drug Alcohol Depend. 2016; 58: 8–21.
Kamarajan C, Pandey AK, Chorlian DB, et al. Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. Int J Psychophysiol. 2015; 98: 182–200.
Cservenka A, Nagel BJ. Risky decision-making: an fMRI study of youth at high risk for alcoholism. Alcohol Clin Exp Res. 2012; 36: 604–615.
Moss HB, Chen ChM, Yi H. Subtypes of Alcohol Dependence in a Nationally Representative Sample. Drug Alcohol Depend. 2007; 91(2–3): 149–158.
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