MicroRNA are small RNA molecules about 22 nucleotides long that do not encode proteins. Their function is to change the expression of proteins by attaching to their mRNA. They participate in various biological processes and pathogenesis of many diseases, including cancer. MicroRNA-26a-5p (miR-26a-5p) takes part in developing many disease entities and may become a potential therapeutic agent.

The article aims to present the current knowledge on miR-26a-5p and consider the possible therapeutic use of this molecule.

State of knowledge:
Many studies on cell lines and model organisms indicate the suppressive function of miR-26a-5p in such neoplasms as breast cancer, pancreatic cancer, prostate cancer, thyroid cancer, or acute myeloid leukemia. In turn, in osteosarcoma cells, miR-26a-5p has an oncogenic character. miR-26a-5p is also associated with other diseases. Many authors have shown that this molecule is related to such entities as rheumatoid arthritis, osteoarthritis, preeclampsia, myocardial injury, or diabetic nephropathy.

Understanding the functions of miR-26a-5p and its participation in human diseases’ pathogenesis gives the possibility of the therapeutic use of this molecule in the future. However, knowledge of this subject is still limited. Further research to assess the efficacy and safety of the therapeutic use of miR-26a-5p is mandatory.

The authors thank Karolina Szela for her help in collecting materials
Zapolnik P, Zapolnik B. MicroRNA-26a-5p: multiple functions, multiple possibilities- a mini-review. J Pre-Clin Clin Res. 2020; 14(4): 130–133.doi: 10.26444/jpccr/128009
Xie T, Huang M, Wang Y, et al. MicroRNAs as Regulators, Biomarkers and Therapeutic Targets in the Drug Resistance of Colorectal Cancer. Cell Physiol Biochem. 2016; 40(1–2): 62–76.
Li Z, Lin C, Zhao L, et al. Oncogene miR-187-5p is associated with cellular proliferation, migration, invasion, apoptosis and an increased risk of recurrence in bladder cancer. Biomed Pharmacother. 2018; 105: 461–469.
Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009; 136(2): 215–23.
Wu L, Belasco JG. Let me count the ways: mechanisms of gene regulation by miRNAs and siRNAs. Mol Cell. 2008; 29(1): 1–7.
Yu T, Chen D, Zhang L, et al. microRNA-26a-5p Promotes Proliferation and Migration of Osteosarcoma Cells by Targeting HOXA5 in vitro and in vivo. Onco Targets Ther. 2019; 12: 11555–11565.
Wang Z, Liu T, Xue W, et al. ARNTL2 promotes pancreatic ductal adenocarcinoma progression through TGF/BETA pathway and is regulated by miR-26a-5p. Cell Death Dis. 2020; 11(8): 692.
Yang Y, Sun Y, Wang H, et al. MicroRNA-221 induces autophagy through suppressing HDAC6 expression and promoting apoptosis in pancreatic cancer. Oncol Lett. 2018; 16(6): 7295–7301.
Zhang XX, Chen H, Li HY, et al. Long non-coding RNA small nucleolar RNA host gene 6 aggravates pancreatic cancer through upregulation of far upstream element binding protein 1 by sponging microRNA-26a-5p. Chin Med J (Engl). 2020; 133(10): 1211–1220.
Shi D, Wang H, Ding M, et al. MicroRNA-26a-5p inhibits proliferation, invasion and metastasis by repressing the expression of Wnt5a in papillary thyroid carcinoma. Onco Targets Ther. 2019; 12: 6605–6616.
Huang ZM, Ge HF, Yang CC, et al. MicroRNA-26a-5p inhibits breast cancer cell growth by suppressing RNF6 expression. Kaohsiung J Med Sci. 2019; 35(8): 467–473.
Jiang W, Min J, Sui X, et al. MicroRNA-26a-5p and microRNA-23b-3p up-regulate peroxiredoxin III in acute myeloid leukemia. Leuk Lymphoma. 2015; 56(2): 460–471.
Guo K, Zheng S, Xu Y, et al. Loss of miR-26a-5p promotes proliferation, migration, and invasion in prostate cancer through negatively regulating SERBP1. Tumour Biol. 2016; 37(9): 12843–12854.
Tothova Z, Gilliland DG. FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system. Cell Stem Cell. 2007; 1(2): 140–152.
Zhang YT, Feng LH, Zhong XD, et al. Vincristine and irinotecan in children with relapsed hepatoblastoma: a single-institution experience. Pediatr Hematol Oncol. 2015; 32(1): 18–25.
Zhang Y, Zhao Y, Wu J, et al. MicroRNA-26-5p functions as a new inhibitor of hepatoblastoma by repressing lin-28 homolog B and aurora kinase a expression. Hepatol Commun. 2018; 2(7): 861–871.
Ghanbari R, Mosakhani N, Asadi J, et al. Downregulation of Plasma MiR-142-3p and MiR-26a-5p in Patients With Colorectal Carcinoma. Iran J Cancer Prev. 2015; 8(3): e2329.
Rasheed Z, Al-Shobaili HA, Rasheed N, et al. MicroRNA-26a-5p regulates the expression of inducible nitric oxide synthase via activation of NF-κB pathway in human osteoarthritis chondrocytes. Arch Biochem Biophys. 2016; 594: 61– 67.
Jin Z, Ren J, Qi S. Human bone mesenchymal stem cells-derived exosomes overexpressing microRNA-26a-5p alleviate osteoarthritis via down-regulation of PTGS2. Int Immunopharmacol. 2020; 78: 105946.
Zhang H, Lu X, Hao Y, et al. MicroRNA-26a-5p alleviates neuronal apoptosis and brain injury in intracerebral hemorrhage by targeting RAN binding protein 9. Acta Histochem. 2020; 122(5): 151571.
Kong B, Qin Z, Ye Z, et al. microRNA-26a-5p affects myocardial injury induced by coronary microembolization by modulating HMGA1. J Cell Biochem. 2019; 120(6): 10756 –10766.
Duan Y, Luo Q, Wang Y, et al. Adipose mesenchymal stem cell-derived extracellular vesicles containing microRNA-26a-5p target TLR4 and protect against diabetic nephropathy [published online ahead of print, 2020 Jun 24]. J Biol Chem. 2020; jbc.RA120.0125.
22. A120.01252222. Müller-Deile J, Schröder P, Beverly-Staggs L, et al. Overexpression of preeclampsia induced microRNA-26a-5p leads to proteinuria in zebrafish. Sci Rep. 2018; 8(1): 3621.
Huang Z, Xing S, Liu M, et al. MiR-26a-5p enhances cells proliferation, invasion, and apoptosis resistance of fibroblast-like synoviocytes in rheumatoid arthritis by regulating PTEN/PI3K/AKT pathway. Biosci Rep. 2019; 39(7): BSR 20182192. 20182192.
Chen L, Zeng W, Yang B, et al. Expression of antisense of microRNA-26a-5p in mesenchymal stem cells increases their therapeutic effects against cirrhosis. Am J Transl Res. 2017; 9(3): 1500–1508.
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