Mechanism of action of 4-hydroxyphenylpyruvate dioxygenase inhibitor herbicide on homoterm animals and humans
More details
Hide details
Hygiene and Ecology Institute Bogomolets National Medical University, Ukraine
Institute of Rural Health in Lublin, Poland
Corresponding author
Iwona Bojar   

Institute of Rural Health, Jaczewskiego 2, 20–090 Lublin, Poland
J Pre Clin Clin Res. 2015;9(2):145-150
It was found that the main mechanisms of action of 4-hydroxyphenylpyruvatedioxygenase inhibitors are the development of tyrosinemia and alternations in thyroid hormone level as a result of hepatic enzyme induction. The main target organs of its action are the eyes, liver and thyroid gland. It was proved that the most adequate model for extrapolation of the effects of tyrosinemia on humans are mice, because their tyrosine aminotransferase activity level is similar to that in humans.
da Silva JG, Nwanze KF, Cousin E. The State of Food Insecurity in the World 2013. The multiple dimensions of food security; FAO, IFAD and WFP: Rome, 2013: pp. 52.
How to Feed the World in 2050, High level expert forum (Rome, 12–13 October 2009); FAO: Rome, 2009: pp. 35.
Tsyhuleva O. The effects of pesticides on health, MAMA-86- Kharkiv Publ: Kharkiv, 2003: pp. 234.
Bergman Å, Heindel JJ, Jobling S, et al. State of the Science of Endocrine Disrupting Chemicals-2012; UN Environment Programme and the WHO: Geneva, 2013: pp. 260.
Balenko NV, Chernychenko IO, Tsymbaliuk SN, et al. Thyroid cancer as a problem of anthropogenic pollution (part-I). Envir Health. 2014; 1(69): 33–37.
Salminen R, Batista MJ, Bidovec M, et al. I – Iodine. In: Geochemical Atlas of Europe. Part 1 – Background Information, Methodology and Maps. Salminen R, (ed.). GTK-FOREGS: Espoo, Finland, 2005: 205–208.
Blair A. Disease and Injury Among Participants in the Agricultural Health Study. J Agric Saf Health. 2005; 11(2): 141–150.
Lee WJ. Cancer Incidence Among Pesticide Applicators Exposed to alachlor in the Agricultural Health Study. Am J Epidem. 2004; 159(4): 373–380.
Herbicide Resistance Action Committee (HRAC). The World of Herbicides (According to HRAC classification on mode of action 2010). Retrieved from: (access: 24.04.2015).
Global availability of information on agrochemicals. Retrieved from: (access: 24.04.2015).List of pesticides and agrochemicals allowed to application in Ukraine. Yunіvest marketing: Кiev, 2014: p. 832.
Boas M, Feldt-Rasmussen U, Skakkebaek NE, Main KM. Environment chemicals and thyroid function. Eur J Endocrinol. 2006; 154: 599–611.
SSanRN–98. Hygienic classification of pesticides by hazard. Approv. By Ministry of Health of Ukraine, 1998.
Pyrazolate, pyrazolinate: Pesticides and plant growth regulators. International agroportal. Directory of ACC. Retrieved from: (access: 24.04.2015).
Tefuryltrione (Ref: AVH-301). Retrieved from: (access: 24.04.2015).
The e-Pesticide Manual: A World Compendium. The e-Pesticide Manual Version 3.2 2005–06. Thirteenth Edition:, 2005. (CD).
US EPA-Pesticides-Fact Sheets for Tembotrione-fs_PC-012801_01-Sep-07.pdf. United States Environmental Protection Agency Washington, D.C. 64 p. Retrieved from: (access: 24.04.2015).
Opinion on the evaluation of mesotrione in the context of council directive 91/414/EEC concerning the placing of plant protection products on the market. European commission: Scientific committee of Plants, 18 July 2002. 14 p. Retrieved from: (access: 24.04.2015).
Matsumoto H. Mode of action of pyrazole herbicides pyrazolate and pyrazoxyfen: HPPD inhibition by common metabolite. New discoveries in agrocemicals; Clark JM, Ohkawa H, Eds. ACS Symposium Series; American Chemical Society: Washington, DC, 2004, 161–171. Chapter doi: 10.1021/bk-2005–0892.ch015.
Beltran E, Fenet H, Cooper JF, Costle CM. Kinetics of chemical degradation of isoxaflutole: influence of the nature of aqueous buffers (alkanoic acid/sodium salt vs. phosphate). Pest Manage Sci. 2001; 57(4): 366–371.
Conclusion on the peer review of the pesticide risk assessment of the active substance tembotrione. EFSA Journal: Parma, Italy, 2013; 11(3): 3131–3181.
Koval`chuk, NM. Toxicological and hygienic substantiation of norms and regulations for herbicides based on 2,4-dichlorphenoxyacetic acid and mesotrione in Ukraine, including radioactively polluted territories Extended abstract of PhD dissertation (medical sciences). Vernadsky National Library of Ukraine, Kiev; 2009.
Antonenko AM, Korshun MM, Peculiarities of toxicodynamics and hazard evaluation of the new oxazole herbicide topramezone. Nauk Visn of NMU. 2011; 2(33): 59–66.
Kovalchuk NM, Bardov VG, Sasinovych LM, et al. Peculiarities of toxicolgical assessment of hazard of substances belonging to triketone class and extrapolation of the results of their experimental research on animals for human. Envir Health. 2008; 3(46): 11–18.
Komatsubara K, Sekino K, Yamada Y, et al. Discovery and development of a new herbicide, benzobicyclon. J Pesticide Sci. 2009; 34(2): 136–144.
Davydov VV, Kleshhev NF. Basics of general biochemistry. Davydov VV, Kleshhev NF, Eds. NTU KhPI Publ: Kharkiv, 2006: pp. 380.
Wu N. Herbicide sulcotrione. Herbicides, Theory and Applications. Soloneski S, Larramendy ML, Eds. InTech, 2011: pp. 527–544.
Rüetschi U, Cerone R, Pérez-Cerda C, et al. Mutations in the 4-hydroxyphenylpyruvate dioxygenase gene (HPD) in patients with tyrosinemia type III. Hum Genet. 2000; 106(6): 654–662.
Rabinowitz LG, Williams LR, Anderson CE, et al. Painful keratoderma and photophobia: hallmarks of tyrosinemia type II. J Pediatr. 1995; 126(2): 266–269.
Boels D, Monteil-Ganière C, Turcant A, et al. Triketone toxicity: a report on two cases of sulcotrione poisoning. Hum Exp Toxicol. 2013; 32(7): 778–782.
Journals System - logo
Scroll to top