RESEARCH PAPER
Helicobacter pylori and rheumatoid arthritis
1
The Parker Institute, Frederiksberg Hospital, Denmark
2
Frederiksberg Hospital, Department of Clinical Microbiology, Rigshospitalet, Denmark
3
Department of Pathology, Denmark
4
Department of Clinical Microbiology , Denmark
5
Deceased
6
Department of Gastroenterology, Denmark
7
Copenhagen University Library, Section for Science and Medicine, Denmark
J Pre Clin Clin Res. 2007;1(1):68–73
KEYWORDS
ABSTRACT
The aim of the research was to evaluate a possible relationship between Helicobacter pylori (H. pylori) and rheumatoid arthritis. The presence of and sero-prevalence of IgG antibodies to H. pylori were determined in 59 Danish rheumatoid-arthritis patients. The sero-prevalence was compared to the prevalence of controls and the background population. H. pylori in infected and uninfected patients were compared with regards to clinical and demographic characteristics, and the extent of their inflammatory disease activity. H. pylori was found in 18 patients (31%). The sero-prevalence of H. pylori was 32%, non-significant to the prevalence of controls (36%), and of the background population (26%). H. pylori /HLO positive and H. pylori /HLO negative patients were similar with regards to clinical and demographic characteristics and inflammatory disease activity. Our results did not show an aetiologic relationship between H. pylori and rheumatoid arthritis, but further studies are needed to discard the hypothesis completely.
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