Future perspectives of the role of Taxines derived from the Yew (Taxus baccata) in research and therapy
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Department of Disease Biology, Faculty of Life Sciences, Copenhagen University, Denmark
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Karina Andersen   

DVM Department of Disease Biology, Faculty of Life Sciences, Copenhagen University, Ridebanevej 9, DK-1870 Frederiksberg C, Denmark
J Pre Clin Clin Res. 2009;3(1):1-4
Yew (Taxus baccata) is a poisonous shrub, who´s toxic properties have been known since antiquity. Recently a molecule, paclitaxel, derived from the Yew has proved to have anticancerous properties, and now this paper raises the debate as to whether or not another molecule, Taxine B, also derived from the Yew, could be a potent new pharmacodrug. Further research in this area is now desperately required, but if positive results are found, they could change our perception of the Yew from being a toxic shrub to being the new medicinal super plant.
Theodoridis GG, Laskaris ELM, van Rozendaal, Verpoorte R: Analysis of taxines in taxus plant material and cell cultures by HPLC photodiode array and HPLC-electrospray mass spectrometry. J Liq Chromatogr R T 2001, 24(15), 2267- 2282.
Jenniskens LHD, van Rozendaal ELM, van Beek TA: Identifi cation of six taxine alkaloids from Taxus baccata needles. J Nat Prod. 1996, 59, 117-123.
Alloatti G, Penna C, Levi RC, Gallo MP, Appendino G,I. Fenoglio I: Eff ects of yew alkaloids and related compounds on guinea-pig isolated perfused heart and papillary muscle. Life Sci 1996, 58(10), 845-854.
Wilson CR, Sauer JM, Hooser SB: Taxines: a review of the mechanism and toxicity of yew (Taxus spp.) alkaloids. Toxicon 2001, 39, 175-185.
von der Werth J, Murphy JJ: Cardiovascular toxicity associated with yew leaf ingestion. Br Heart J 1994, 72, 92-93.
Yersin B, Frey JG, Schaller MD, Nicod P,C. Perret C: Fatal cardiac arrhythmias and shock following yew leaves ingestion. Ann Emerg Med 1987, 16(12), 1396-1397.
Willaert W, Claessens P B, Vankelecom B, Vanderheyden M: Intoxication with Taxus Baccata: Caridac arrythmias following yew leaves ingestion. J Pacing Clin Electrophysiol 2002, 24, (4(I)), 511-512.
Andersen KB, Brimer L, Skaanild MT, Bertelsen MF: Personal communication. 2009.
Tekol Y: Negative chronotropic and atrioventricular blocking eff ects of taxin on isolated frog hearts and its acute toxicity in mice. Planta Med 1985, 51(5), 357-360.
Tekol Y, Kameyama M: Electrophysiologische Untersuchungen uber den Wirkungsmechanismus des Eibentoxins Taxin auf das Herz Arzneimittelforschung 1987, 37(4), 428-431.
Tekol Y, Gogusten B: Comparative Determination of the Cardioselectivity of Taxine and Verapamil in the Isolated Aorta, Atrium and Jejunum Preperations of Rabbits. Artzneimittelforschung. 1999, 49(8), 673- 678.
Tekol Y, Erenmemisoglu A, Erdogan N, Ustun H, Sunguroglu H: Subacute and chronic toxicity of taxine in mice. Hamdard 1991, 34, 67-72.
Tekol Y: The Medieval Physician Avicenna Used an Herbal Calcium Channel Blocker, Taxus baccata L. Phytothe Res 2007, 21, 701-702.
Tiwary AK, Puschner B,H. Kinde H: Diagnosis of Taxus (Yew) poisoning in a horse. J Vet Diagn Invest 2005, 17, 252-255.
Cunningham JG: Textbook of Veterinary Physiology. Third Edition. WB. Saunders Company, 2002, USA.
Nelson RW, Couto CG: Small Animal Internal Medicine. Third edition. Mosby, Missouri, 2003, USA.
Ellekvist P, Ricke CH, Litman T, Salanti A, Colding H, Zeuthen T, Klaerke DA: Molecular cloning of the K+ channel from the malaria parasite Plasmodium falciparum. Biochem Bioph Res Commun 2004, 318, 477-484.
Ellekvist P, Maciel J, Mlambo G, Ricke CH, Colding H, Klaerke DA, Kumar N(2008): Critical role of a K+ channel in Plasmodium berghei transmission revealed by targeted gene disruption. PNAS 2008, 105(17), 6398-6402.
DiFrancesco D: Funny channels in the control of cardiac rhytm and mode of action of selective blockers. Pharmacol Res 2006, 53, 399- 406.
Hare WR: Bovine Yew (Taxus spp.) Poisoning. Large animal practice 1998, l. 19, 24-28.
Thomas PA, Polwart A: Taxus baccata L. J Ecol. 2003, 91(3), 489- 524.
Tekol Y: Acute toxicity of taxine in mice and rats. Vet Hum Toxicol 1991, 33(4) 337-338.
Beasley V: (1999): Other Plants that Aff ect the Heart. I: Beasley V & R.H. Poppenga (editors) (1999): Veterinary Toxicology. (Electronic Textbook). International Veterinary Information Service – IVIS, Ithaca NY 14852, USA. chapter_frm.asp?LA=1# (5. August 2008).
Shanker K, Pathak NKR, Trived VP, Chansuria JPN, Pandey VB: An evaluation of toxicity of Taxus baccata Linn. (Talispatra) in experimental animals. J Ethnopharmacol. 2002, 79, 69-73.
Wikimedia Foundation (2009a): search for: Heart failure. Last modifi ed on 22. May 2009. Heart_failure (9. June 2009).
Wikimedia Foundation (2009b): (webpage) search for: Malaria. Last modifi ed on 1. June 2009. wiki/Malaria (9. June 2009).
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