Effect of environmental parameters on the concentration of nickel (Ni) in bones of the hip joint from patients with osteoarthritis
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Department of Biology and Medical Parasitology, Pomeranian Medical University, Szczecin, Poland
Department of Health Education, University of Szczecin, Szczecin, Poland
Chair and Clinic of Orthopaedics and Traumatology, Pomeranian Medical University, Szczecin, Poland
Corresponding author
Danuta Kosik-Bogacka   

Department of Biology and Medical Parasitology, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland
J Pre Clin Clin Res. 2016;10(1):6-11
Bone trace elements levels including nickel (Ni) depend on biological and environmental factors: age, gender, remodeling state, exposure to occupational and environmental pollution, smoking, diet, and surgical implants.

The aim of this study was to determine Ni concentrations in bones of femur heads obtained from patients with osteoarthritis.

Material and Methods:
A total of 111 samples of hip joint bones (cartilage, cancellous bone and compact bone) collected from patients from north-western Poland were examined. Ni concentration was determined by ICP-AES (atomic absorption spectrophotometry).

It was found that differences in Ni concentrations were statistically significant between cartilage and compact bone. Cartilage Ni concentrations were higher in patients with fractured femur neck than patients with osteoarthritis. Furthermore, higher Ni levels were also found in samples obtained from smokers compared to nonsmokers. In cancellous bone, higher Ni concentrations were found in samples from patients who had received implants than those without them. Moreover, higher Ni concentrations in cancellous bone were found in patients occupationally exposed to heavy metals than in those not exposed.

The bone tissue reflects long-term exposure to Ni and may be used as a bioindicator to study the process of Ni accumulation in the human body.

Iyaka YA. Nickel in soils: A review of its distribution and impacts. Sci Res Essays. 2011; 6: 6774–6777.
Pizzutelli S. Systemic nickel hypersensitivity and diet: myth or reality? Eur Ann Allergy Clin Immunol. 2011; 43: 5–18.
Sunderman JF. Biological monitoring of nickel in humans (Conference Paper). Scand J Work Environ Health. 1993; 19: 34–38.
Poonkothai M, Shyamala Vijayavathi B. Nickel as an essential element and a toxicant. Int J Environ Sci. 2012; 1: 285–288.
Eisler R. Nickel hazards to fish, wildlife and invertebrates: a synoptic review. Contaminant Hazard Rev. 1998; report no.: 34.
Zhao J, Shi X, Castranova V, Ding M. Occupational toxicology of nickel and nickel compounds. J Environ Pathol Toxicol Oncol. 2009; 28: 177–208.
Barceloux DG. Nickel. Clin Toxicol. 1999; 37: 239–258.
Kabata-Pendias A, Mukherjee AB. Trace Elements from Soil to Human. Berlin: Springer-Verlag, 2007.
Megaye R, Zhao J, Bowman L, Ding M. Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles. Exp Ther Med. 2012; 4: 551–561.
Yoshinaga J, Suzuki T, Morita M, Hayakawa M. Trace elements in ribs of elderly people and elemental variation in the presence of chronic diseases. Sci Total Environ. 1995; 162: 239–252.
Cempel M, Nikel G. Nickel: A review of its sources and environmental toxicology. Pol J Environ Stud. 2006; 15: 375–382.
Świerczyńska-Machura D, Kieć-Świerczyńska M, Kręcisz B, Pałczyński C. Allergy to components of implants. Alergia Astma Immunol. 2004; 9: 128–132.
Hallab NJ, Merrit K, Jacobs JJ. Metal sensitivity in patients with orthopaedic implants. J Bone Joint Surg. (Am) 2001; 83: 428–436.
Kubaszewski U, Zio A-Frankowska A, Frankowski M, Rogala P, Gasik Z, Kaczmarczyk J, Nowakowski A, Dabrowski M, Labedz W, Mi Ksisiak G, Gasik R. Comparison of trace element concentration in bone and intervertebral disc tissue by atomic absorption spectrometry techniques. J Orthop Surg Res. 2014; 9: 99.
Lanocha N, Kalisinska E, Kosik-Bogacka DI, Budis H, Sokolowski S, Bohatyrewicz A, Lanocha A. The effect of environmental factors on concentration of trace elements in hip joint bones of patients after hip replacement surgery. Ann Agric Environ Med. 2013; 20: 487–493.
Lanocha N, Kalisinska E, Kosik-Bogacka DI, Budis H, Sokolowski S, Bohatyrewicz A. Concentrations of trace elements in bones of the hip joint from patients after hip replacement surgery. J Trace Elem Med Biol. 2012; 26: 20–25.
Budis H, Kalisinska E, Lanocha N, Kosik-Bogacka D, Sokolowski S, Dobiecki K, Kolodziej L, Bohatyrewicz A. The concentration of manganese, iron, and strontium in hip joint bone obtained from patients undergoing hip replacement surgery. J Trace Elem Med Biol. 2014; 28: 39–44.
Brodziak-Dopierała B, Kwapulinski J, Okrajni J, Kowol J, Kosterska E, Suchy A, Sobczyk K. The estimation of nickel interaction with other elements in an osseous tissue of femur head. Acta Toxicol. 2007; 15: 69–74.
Brodziak-Dopierala B, Kwapulinski J, Sobczyk K, Kowol J. The occurrence of nickel and other elements in tissues of the hip joint. Ecotox Environ Saf. 2011; 74: 630–635.
Kwapulinski J, Brodziak-Dopierala B, Kosterska E. Accumulation of Ni and Cr in the tissue of the femoral head. Environ Med. 2010; 13: 15–22.
Sameer AA, Fawzi B, Mohai F. Sorption of copper and nickel by spent animal bones. Chemosphere 1999; 39: 2087–2096.
Law MR, Hackshaw AK. A metaanalysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect. BMJ 1997; 315: 841–846.
Compston J. Editorial: smoking and the skeleton. J Clin Endocr Metab. 2007; 92: 428–429.
Kwapulinski J, Nogaj E, Babula M, Suflita M. The effect of passive smoking on the nickel content in the pharyngeal tonsils in children. Environ Med. 2010; 13: 23–30.
Stojanovic D, Nikic D, Lazarevic K. The level of nickel In smoker’s blond and urine. Cent Eur J Publ Health. 2004; 12: 187–189.
Langauer-Lewowicka H, Pawlas K. Nickel – environmental allergen. Environ Med. 2010; 13: 7–10.
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