RESEARCH PAPER
Effect of environmental parameters on the concentration of nickel (Ni) in bones of the hip joint from patients with osteoarthritis
| 1 | Department of Biology and Medical Parasitology, Pomeranian Medical University, Szczecin, Poland |
| 2 | Department of Health Education, University of Szczecin, Szczecin, Poland |
| 3 | Chair and Clinic of Orthopaedics and Traumatology, Pomeranian Medical University, Szczecin, Poland |
CORRESPONDING AUTHOR
Danuta Kosik-Bogacka
Department of Biology and Medical Parasitology, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland
Department of Biology and Medical Parasitology, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland
J Pre Clin Clin Res. 2016;10(1):6–11
KEYWORDS
ABSTRACT
Introduction:
Bone trace elements levels including nickel (Ni) depend on biological and environmental factors: age, gender, remodeling state, exposure to occupational and environmental pollution, smoking, diet, and surgical implants.
Objective:
The aim of this study was to determine Ni concentrations in bones of femur heads obtained from patients with osteoarthritis.
Material and Methods:
A total of 111 samples of hip joint bones (cartilage, cancellous bone and compact bone) collected from patients from north-western Poland were examined. Ni concentration was determined by ICP-AES (atomic absorption spectrophotometry).
Results:
It was found that differences in Ni concentrations were statistically significant between cartilage and compact bone. Cartilage Ni concentrations were higher in patients with fractured femur neck than patients with osteoarthritis. Furthermore, higher Ni levels were also found in samples obtained from smokers compared to nonsmokers. In cancellous bone, higher Ni concentrations were found in samples from patients who had received implants than those without them. Moreover, higher Ni concentrations in cancellous bone were found in patients occupationally exposed to heavy metals than in those not exposed.
Conclusions:
The bone tissue reflects long-term exposure to Ni and may be used as a bioindicator to study the process of Ni accumulation in the human body.
Bone trace elements levels including nickel (Ni) depend on biological and environmental factors: age, gender, remodeling state, exposure to occupational and environmental pollution, smoking, diet, and surgical implants.
Objective:
The aim of this study was to determine Ni concentrations in bones of femur heads obtained from patients with osteoarthritis.
Material and Methods:
A total of 111 samples of hip joint bones (cartilage, cancellous bone and compact bone) collected from patients from north-western Poland were examined. Ni concentration was determined by ICP-AES (atomic absorption spectrophotometry).
Results:
It was found that differences in Ni concentrations were statistically significant between cartilage and compact bone. Cartilage Ni concentrations were higher in patients with fractured femur neck than patients with osteoarthritis. Furthermore, higher Ni levels were also found in samples obtained from smokers compared to nonsmokers. In cancellous bone, higher Ni concentrations were found in samples from patients who had received implants than those without them. Moreover, higher Ni concentrations in cancellous bone were found in patients occupationally exposed to heavy metals than in those not exposed.
Conclusions:
The bone tissue reflects long-term exposure to Ni and may be used as a bioindicator to study the process of Ni accumulation in the human body.
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