Assessment of the expression of neutrophil CD11b receptors in preterm infants
More details
Hide details
Polish Mothers’ Health Centre Research Institute, Łódź, Poland
Keck School of Medicine, University of Southern California, Los Angeles, USA
Corresponding author
Krzysztof Zięba   

Polish Mother’s Health Centre Research Institute, Rzgowska 281/289, 93-338 Łódź, Poland.
J Pre Clin Clin Res. 2009;3(1):54-57
The objective of the study was to assess the neutrophil surface expression of CD11b as a marker of early onset infection in preterm infants. The study comprised 16 pre-term infants with gestational age of 26-32 weeks, suspected of infection within 48 hours of life, and 13 healthy term infants who served as the control. A full sepsis screen was performed in both groups. There was no increase in CD11b expression on neutrophil surface even in infants with elevated CRP. None of the infants had positive blood cultures. The results in this study of pre-term infants born before 33 weeks of gestation showed that there is no increase in neutrophil CD11b expression; however, none of the infants had positive blood cultures. The diagnostic utility of neutrophil CD11b expression in pre-term infants needs to be further evaluated.
Guzick DS, Winn K: The association of chorioamnionitis with preterm delivery. Obstet Gynecol 1985, 65, 11-16.
Placzek MM, Whitelaw A: Early and late neonatal septicemia. Arch Dis Child 1983, 58, 728-731.
Boyer KM, Gadzala C, Burd LI, Fisher DE, Paton JB, Gotoff SP: Selective intrapartum chemoprophylaxis of neonatal group B streptococcal early onset disease. I. Epidemiologic rationale. J Infect Dis 1983, 148, 795- 801.
Ohlsson A, Vearncombe M: Congenital and nosocomial sepsis in infants born in regional perinatal unit: cause, outcome, and white blood cell response. Am J Obstet Gynecol 1987, 156, 407-413.
Gerdes JS: Clinicopathological approach to the diagnosis of neonatal sepsis. Clin Perinatol 1991, 18, 361-381.
Thompson PJ, Greenough A, Gamsu HR, Nicolaides KH, Philpott- Howard J: Congenital bacterial sepsis in very preterm infants. J Med Microbiol 1992, 36, 117-120.
Cassell GH, Davis RO, Waites KB, Brown MB, Marriott PA, Stagno S, Davis JK: Isolation of Mycoplasma hominis and Ureaplasma urealyticum from amniotic fl uid at 16-20 weeks of gestation: potential eff ect on outcome of pregnancy. Sex Transm Dis 1983, 10(4 suppl), 294-302.
Carroll SG, Papaioannou S, Ntumaah IL, Philpott-Howard J, Nicolaides KH: Lower genital tract swabs in the prediction of intrauterine infection in preterm prelabour rupture of the membranes. Br J Obstet Gynaecol 1996, 103, 54-59.
Ng PC: Diagnostic markers of infection in neonates. Arch Dis Child Fetal Neonatal Ed 2004, 89, 3.
Fjaertoft G, Hakansson L, Ewald U, Foucard T, Venge P: Neutrophils from term and preterm newborn infants express the high affi nity Fcgamma-receptor I (CD64) during bacterial infection. Pediatr Res 1999, 45, 871-876.
Weirich E, Rabin RL, Maldonado Y, Benitz W, Modler S, Herzenberg LA: Neutrophil CD11b expression as a diagnostic marker for early-onset neonatal infection. J Pediatr 1998, 132, 445-451.
Lehr HA, Krombach F, Műnzing S, Bodlaj R, Glaubitt SI, Seiff ge D, Hűbner C, von Andrian UH, Messmer K: In vitro eff ect of oxidized low density lipoprotein on CD11b/CD18 and L-selectin presentation on neutrophils and monocytes with relevance for the in vivo situation. Am J Pathol 1995, 146, 218-227.
Simms HH, D’Amico R: Lipopolysaccharide induces intracytoplasmic migration of the polymorphonuclear leukocyte CD11b/CD18 receptor. Shock 1995, 3, 196-203.
Nupponen I, Andersson S, Jarvenpaa AL, Kautiainen H, Repo H: Neutrophil CD11b expression and circulating interleukin-8 as diagnostic markers for early-onset neonatal sepsis. Pediatrics 2001, 108, 12-17.
Romero R, Mazor M: Infection and preterm labor. Clin Obstem Gynecol 1988, 31, 553-584.
Journals System - logo
Scroll to top