Role of peripheral glutamate receptors in regulation of gastric secretion and motor function of stomach
More details
Hide details
Pharmaco-Physiology Department, Taras Shevchenko State University, Kiev, Ukraine
Tetyana Beregova   

Pharmaco-Physiology Department, Taras Shevchenko State University, Akad. Glushkov av. 2, Kiev, Ukraine.
J Pre Clin Clin Res. 2007;1(2):107–111
Anatomical, physiological and pharmacological evidence suggests that glutamate is neurotransmitter in the peripheral nervous system. The aim of this review is to show the distribution of the glutamatergic system within the mammalian gastric wall and how this system regulates gastric functions. There have been reports that different types of glutamate receptors are involved in regulation of gastric acid secretion, gastric motility and food intake.
Furness JB, Bornstein JC, Pompolo S, Young HM, Kunze WAA, Kelly H: The circuitry of the enteric nervous system. Neurogastroenterol 1994, 6, 241-253.
Liu MT, Rothstein JD, Gershon MD, Kirchgessner AL: Glutamatergic enteric neurons. J Neurosci 1997, 17, 4764-4784.
Monaghan DT, Bridges RJ, Cotman CW: The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu Rev Pharmacol Toxicol 1989, 29, 365-402.
Gasic G: Systems and molecular genetic approaches converge to tackle learning and memory. Neuron 1995, 15, 507-512
Reis HJ, Massensini AR, Prado MA, Gomez RS, Gomez MV, Romano- Silva MA: Calcium channels coupled to depolarization-evoked glutamate release in the myenteric plexus of guinea-pig ileum. Neuroscience 2000, 101, 237-242.
Ren J, Hu HZ, Liu S, Xia Y, Wood JD: Glutamate receptors in the enteric nervous system: ionotropic or metabotropic? Neurogastroenterol Motil 2000, 12, 257-264.
Tsai LH, Taniyama K, Tanaka C: Gamma-aminobutyric acid stimulates acid secretion from the isolated guinea pig stomach. Am J Physiol 1987, 253, 601-606.
Tsai LH, Tsai W, Wu JY: Action of myenteric GABAergic neurons in the guinea pig stomach. Neurochem 1993, 23, 187-193
Tsai LH: Function of GABAergic and glutamatergic neurons in the stomach. J Biomedical Science 2005, 12, 255-266.
Tsai LH, Tsai W, Wu JY: Effect of L-glutamic acid on acid secretion and immunohistochemical localization of glutamatergic neurons in the rat stomach. J Neurosci Res 1994, 38, 188-195.
Kirchgessner AL, Liu MT: Immunohistochemical localization of nicotinic acetylcholine receptors in the guinea pig bowel and pancreas. J Comp Neurol 1998, 390, 497-514.
Steffens AB, Leuvenink H, Scheurink AJ: Effects of monosodium glutamate (umami taste) with and without guanosine 5’-monophosphate on rat autonomic responses to meals. Physiol Behav 1994, 56, 59-63.
Burns GA, Stephens KE: Expression of mRNA for the N-methyl-Daspartate (NMDAR1) receptor and vasoactive intestinal polypeptide (VIP) co-exist in enteric neurons of the rat. J Auton Nerv Syst 1995, 55, 207-210.
Burns GA, Stephens KE, Benson JA: Expression of mRNA for the Nmethyl- D-aspartate (NMDAR1) receptor by the enteric neurons of the rat. Neurosci Lett 1994, 170, 87-90.
Cleland TA, Selverston AI: Glutamate-gated inhibitory currents of central pattern generator neurons in the lobster stomatogastric ganglion. J Neurosci 1995, 15, 6631-6639.
Gutovitz S, Birmingham JT, Luther JA, Simon DJ, Marder E: GABA enhances transmission at an excitatory glutamatergic synapse. J Neurosci 2001, 21, 5935- 5943.
Panico WH, Cavuto NJ, Kallimanis G, Nguyen C, Armstrong DM, Benjamin SB, Gillis RA, Travagli RA: Functional evidence for the presence of nitric oxide synthase in the dorsal motor nucleus of the vagus. Gastroenterol 1995, 109, 1484-1491.
Tong Q, Ma J, Kirchgessner AL: Vesicular glutamate transporter 2 in the brain-gut axis. Neuroreport 2001, 12, 3929-3934.
Kirchgessner AL, Tamir H, Gershon MD: Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity-induced expression of Fos immunoreactivity. J Neurosci 1992, 12, 235-248.
Howell JA, Matthews AD, Swanson KC, Harmon DL, Matthews JC: Molecular identification of high affinity glutamate transporters in sheep and cattle forestomach, intestine, liver, kidney, and pancreas. J Anim Sci 2001, 79, 1329-1336.
Ozawa S, Kamiya H, Tsuzuki K: Glutamate receptors in the mammalian central nervous system. Prog Neurobiol 1998, 54, 581-618.
Asztely F, Gustafsson B: Ionotropic glutamate receptors. Their possible role in the expression of hippocampal synaptic plasticity. Mol Neurobiol 1996, 12, 1-11.
Bochet P, Rossier J: Molecular biology of excitatory amino acid receptors: subtypes and subunits. EXS 1993, 63, 224-233.
Michaelis EK: Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog Neurobiol 1998, 54, 369-415.
Kirchgessner AL, Liu MT, Alcantara F: Excitotoxicity in the enteric nervous system. J Neurosci 1997, 17, 8804-8816.
Larzabal A, Losada J, Mateos JM, Benitez R, Garmilla IJ, Kuhn R, Grandes P, Sarria R: Distribution of the group II metabotropic glutamate receptors (mGluR2/3) in the enteric nervous system of the rat. Neurosci Lett 1999, 276, 91-94.
Ren J, Hu HZ, Liu S, Xia Y, Wood JD: Glutamate modulates neurotransmission in the submucosal plexus of guinea-pig small intestine. Neuroreport 1999, 10, 3045-3048.
Burns GA, Ulibarri C, Stephens KE: Transiently catecholaminergic cells in the fetal rat express mRNA for the glutamate NMDAR1 receptor. Brain Res 1996, 718, 117-123.
Tsai LH, Lee YJ, Wu JY: Role of N-methyl-Daspartate receptors in gastric mucosal blood flow induced by histamine. J Neurosci Res 2004, 77, 730-738.
Kirchgessner AL: Glutamate in the enteric nervous system. Curr Opin Pharmacol 2001, 1, 591-596.
McRoberts JA, Coutinho SV, Marvizon JC, Grady EF, Tognetto M, Sengupta JN, Ennes HS, Chaban VV, Amadesi S, Creminon C, Lanthorn T, Geppetti P, Bunnett NW, Mayer EA: Role of peripheral Nmethyl-D-aspartate (NMDA) receptors in visceral nociception in rats. Gastroenterology 2001, 120, 1737-1748.
Hollmann M, Heinemann S: Cloned glutamate receptors. Annu Rev Neurosci 1994, 17, 31-108.
Stern P, Behe P, Schoepfer R, Colquhoun D: Single channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptors. Proc R Soc Lond B Biol Sci 1992, 250, 271-277.
Huettner JE: Glutamate receptor channels in rat DRG neurons: activation by kainate and quisqualate and blockade of desensitization by Con A. Neuron 1990, 5, 255-266.
Wong LA, Mayer ML: Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy- 5-methyl-4 isoxazolepropionic acid- and kainate-preferring glutamate receptors. Mol Pharmacol 1993, 44, 504-510.
Wong LA, Mayer ML, Jane DE, Watkins JC: Willardiines differentiate agonist binding sites for kainate – versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons. J Neurosci 1994, 14, 3881- 3897.
Chittajallu R, Vignes M, Dev KK, Barnes JM, Collingridge GL, Henley JM: Regulation of glutamate release by presynaptic kainate receptors in the hippocampus. Nature 1996, 379, 78-81.
Krenz WD, Nguyen D, Perez-Acevedo NL, Selverston AI: Group I, II, and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion. J Neurophysiol 2000, 83, 1188-1201.
Pin JP, Duvoisin R: The metabotropic glutamate receptors: structure and functions. Neuropharmacol 1995, 34, 1-26.
Moroni F, Luzzi S, Franchi-Micheli S, Zilletti L: The presence of Nmethyl- D-aspartate-type receptors for glutamic acid in the guinea pig myenteric plexus: Neurosci Lett 1986, 68, 57-62.
Giaroni C, Zanetti E, Marino F, Cosentino M, Senaldi A, Somaini L, Ferrari M, Bombelli R, Lecchini S, Frigo G: Glutamate receptors of the AMPA type modulate neurotransmitter release and peristalsis in the guinea-pig isolated colon. Life Sci 2000, 67, 1747-1757.
Sinsky M, Donnerer J: Evidence for a neurotransmitter role of glutamate in guinea pig myenteric plexus neurons. Neurosci Lett 1998, 258, 109- 112.
Jankovic SM, Milovanovic D, Matovic M, Iric-Cupic V: The effects of excitatory amino acids on isolated gut segments of the rat. Pharmacol Res 1999, 39, 143-148.
Burns GA, Ritter RC: The non-competitive NMDA antagonist MK-801 increases food intake in rats. Pharmacol Biochem Behav 1997, 56, 145- 149.
Stanley BG, Ha LH, Spears LC, Dee MG: Lateral hypothalamic injections of glutamate, kainic acid, D,L-alpha-amino-3-hydroxy-5- methyl-isoxazole propionic acid or N-methyl-D-aspartic acid rapidly elicit intense transient eating in rats. Brain Res 1993, 613, 88-95.
Stanley BG, Willett VL, Donias HW, Dee MG, Duva MA: Lateral hypothalamic NMDA receptors and glutamate as physiological mediators of eating and weight control. Am J Physiol 1996, 270, 443- 449.
Wirtshafter D, Krebs JC: Control of food intake by kainate/quisqualate receptors in the median raphe nucleus. Psychopharmacol 1990, 101, 137-141.
Covasa M, Ritter RC, Burns GA: NMDA receptor participation in control of food intake by the stomach. Am J Physiol Regul Integr Comp Physiol 2000, 278, 1362-1368.
Zheng H, Kelly L, Patterson LM, Berthoud HR: Effect of brain stem NMDA-receptor blockade by MK-801 on behavioral and fos responses to vagal satiety signals. Am J Physiol 1999, 277, 1104-1111.
Kaneko H, Tache Y: TRH in the dorsal motor nucleus of vagus is involved in gastric erosion induced by excitation of raphe pallidus in rats. Brain Res 1995, 699, 97-102.
Tsai LH, Huang LR, Chen SH, Liu HJ, Chou LS: Effects of L-glutamic acid on acid secretion and mucosal blood flow in the rat stomach. Chin J Physiol 1999, 42, 181-187.
Tsuchiya S, Horie S, Yano S, Watanabe K: Stimulatory effects of centrally injected kainate and N-methyl-D-aspartate on gastric acid secretion in anesthetized rats. Brain Res 2001, 914, 115-122.
Yang H: TRH in dorsal vagal complex mediates acid response to excitation of raphe pallidus neurons in rats. Am J Physiol 1993, 265, 880-886.
Dziubenko N, Beregova T: About the role of glutamate NMDAreceptors in realisation gastric acid secretion in rats. Acta Physiologica 2007, 191(658), 95.
Stepanova Yu, Shtanova L, Beregova T: The pharmacological and surgical analysis localization of peripheral glutamate receptors NMDAtype which are attracted in regulation of gastric acid secretion in rats. V International scientific-practical conference for students, postgraduate and young ‘Shevchenkivska vesna’: The condition of science: achievements, problems and perspective of development, Kiev 2007, 67- 69.
Falalyeyeva T, Beregova T, Shtanova L, Dryvetska T: About the different role of the central and peripheral AMPA/kainate glutamate receptors in regulation of basal gastric acid secretion in rats. Strbak V (Ed.): International Proceedings. Selected Papers of the Joint Meeting of the Physiological Society and FEPS in Bratislava, Slovak Republic: Medimond 2007, 21-24.