Role of orexins in regulation of gastrointestinal motility
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Laboratory of Clinical Physiology, Department of Biostructure and Animal Physiology, Faculty of Veterinary Medicine, University of Environmental and Life Sciences, Wroclaw, Poland
Krzysztof Romański   

Laboratory of Clinical Physiology, Department of Biostructure and Animal Physiology, Faculty of Veterinary Medicine, University of Environmental and Life Sciences, Norwida 31, 50-375 Wroclaw, Poland.
J Pre Clin Clin Res. 2009;3(2):71–75
Orexins (hypocretins) – hypothalamic peptides, appear to play an important role in the regulation of energy balance,feeding behaviour and sleep-wakefulness state. The presence of orexins and their receptors in the gastrointestinal tract argues also for a local action of these neuropeptides. The structure of orexin A and orexin B molecules is similar and these peptides act via two orexin receptors OX1R and OX2R. Orexin actions on gastrointestinal motor activity are complex and can involve central and peripheral mechanisms. The reported data suggest that orexins acting centrally within the dorsomedial nucleus exert a potent increase of gastric motility. Orexins also modulate small bowel motility through peripheral actions. These neuropeptides signifi cantly increase the intestinal motility in isolated segments of the small bowel and colon. Furthermore, orexin A and orexin B increase the length of the MMC cycle. Orexins might therefore be included into the group of regulatory peptides controlling digestive tract motility.
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