REVIEW PAPER
Role of orexins in regulation of gastrointestinal motility
 
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Laboratory of Clinical Physiology, Department of Biostructure and Animal Physiology, Faculty of Veterinary Medicine, University of Environmental and Life Sciences, Wroclaw, Poland
CORRESPONDING AUTHOR
Krzysztof Romański   

Laboratory of Clinical Physiology, Department of Biostructure and Animal Physiology, Faculty of Veterinary Medicine, University of Environmental and Life Sciences, Norwida 31, 50-375 Wroclaw, Poland.
 
J Pre Clin Clin Res. 2009;3(2):71–75
KEYWORDS
ABSTRACT
Orexins (hypocretins) – hypothalamic peptides, appear to play an important role in the regulation of energy balance,feeding behaviour and sleep-wakefulness state. The presence of orexins and their receptors in the gastrointestinal tract argues also for a local action of these neuropeptides. The structure of orexin A and orexin B molecules is similar and these peptides act via two orexin receptors OX1R and OX2R. Orexin actions on gastrointestinal motor activity are complex and can involve central and peripheral mechanisms. The reported data suggest that orexins acting centrally within the dorsomedial nucleus exert a potent increase of gastric motility. Orexins also modulate small bowel motility through peripheral actions. These neuropeptides signifi cantly increase the intestinal motility in isolated segments of the small bowel and colon. Furthermore, orexin A and orexin B increase the length of the MMC cycle. Orexins might therefore be included into the group of regulatory peptides controlling digestive tract motility.
 
REFERENCES (40)
1.
Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M: Orexin and orexin receptors: a family of hypothalamic neuropeptides and G protein- coupled receptors that regulate feeding behavior. Cell 1998, 92, 573-585.
 
2.
De Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS 2nd, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliff e JG: The hypocretins: hypothalamus-specifi c peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 1998, 95, 322-327.
 
3.
Chen XW, Huang W, Yan JA, Fan HX, Guo N, Lu J, Xiu Y, Gu JL, Zhang CX, Ruan HZ, Hu ZA, Yu ZP, Zhou Z: Reinvestigation of the eff ect of orexin A on catecholamine release from adrenal chromaffi n cells. Neurosci Lett 2008, 436, 181-184.
 
4.
Heinonen MV, Purhonen AK, Makela KA, Herzig KH : Functions of orexins in peripheral tissues. Acta Physiol (Oxf) 2008, 192, 471-485.
 
5.
Voisin T, Rouet-Benzineb P, Reuter N, Laburthe M: Orexins and their receptors: structural aspects and role in peripheral tissues. Cell Mol Life Sci 2003, 60, 72-87.
 
6.
Kohno D, Gao HZ, Muroya S, Kikuyama S, Yada T: Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channeldependent mechanisms and cross-talk with leptin and orexin. Diabetes 2003, 52, 948-956.
 
7.
Lopez M, Lage R, Tung YC, Challis BG, Varela L, Virtue S, O’Rahilly S, Vidal-Puig A, Dieguez C, Coll AP: Orexin expression is regulated by alpha-melanocyte-stimulating hormone. J Neuroendocrinol 2007, 19, 703-707.
 
8.
Kirchgessner AL, Liu M: Orexin synthesis and response in the gut. Neuron 1999, 24, 941-951.
 
9.
Katayama Y, Homma T, Honda K, Hirai K: Actions of orexin-A in the myenteric plexus of the guinea-pig small intestine. Neuroreport 2003, 14, 1515-1518.
 
10.
Kirchgessner AL, Naslund E: Orexins (Hypocretins) in the gut. Hypocretins integrators of physiological functions (1st edn.) by Luis de Lecea and J. Gregor Sutclife. Springer 2005, 385-393.
 
11.
Matsuo K, Kaibara M, Uezono Y, Hayashi H, Taniyama K, Nakane Y: Involvement of cholinergic neurons in orexin-induced contraction of guinea pig ileum. Eur J Pharmacol 2002, 452, 105-109.
 
12.
Grabauskas G, Moises HC: Gastrointestinal-projecting neurones in the dorsal motor nucleus of the vagus exhibit direct and viscerotopically organized sensitivity to orexin. J Physiol 2003, 549, 37-56.
 
13.
Korczyński W, Ceregrzyn M, Matyjek R, Kato I, Kuwahara A, Woliński J, Zabielski R: Central and local (enteric) action of orexins. J Physiol Pharmacol 2006, 57(Suppl 6), 17- 42.
 
14.
Kirchgessner AL: Orexins in the brain-gut axis. Endocrine Reviews 2002, 23, 1-15.
 
15.
De Lecea L, Sutcliff e JG: The hypocretins and sleep. FEBS J 2005, 272, 5675-5688.
 
16.
Kukkonen JP, Holmqvist T, Ammoun S, Akerman KE: Functions of the orexinergic/hypocretinergic system. Am J Physiol 2002, 286, C1567-C1591.
 
17.
Selbach O, Haas HL: Hypocretins: the timing of sleep and waking. Chronobiol Int 2006, 23, 63-70.
 
18.
Heinonen MV, Purhonen AK, Miettinen P, Paakkonen M, Pirinen E, Alhava E, Akerman K, Herzig KH: Apelin, orexin-A and leptin plasma levels in morbid obesity and eff ect of gastric banding. Regul Pept 2005, 130, 7-13.
 
19.
Dall’aglio C, Pascucci L, Mercati F, Giontella A, Pedini V, Ceccarelli P: Immunohistochemical identifi cation and localization of orexin A and orexin type 2 receptor in the horse gastrointestinal tract. Res Vet Sci 2009, 86, 189-193.
 
20.
Dall’aglio C, Pascucci L, Mercati F, Giontella A, Pedini V, Scocco P, Ceccarelli P: Identifi cation of orexin A- and orexin type 2 receptorpositive cells in the gastrointestinal tract of neonatal dogs. Eur J Histochem 2008, 52, 229-235.
 
21.
Baccari MC, Calamai F: Infl uence of orexin A on the mechanical activity of mouse gastric strips. Regul Pept 2008, 146, 67-72.
 
22.
Naslund E, Ehrstrom M, Ma J, Hellstrom PM, Kirchgessner AL: Localization and eff ects of orexin on fasting motility in the rat duodenum. Am J Physiol 2002, 282, G470-G479.
 
23.
Lawrence CB, Snape AC, Baudoin FM, Luckman SM: Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers. Endocrinology 2002, 143, 155-162.
 
24.
Kobashi M, Furudono Y, Matsuo R, Yamamoto T: Central orexin facilitates gastric relaxation and contractility in rats. Neurosci Lett 2002, 332, 171-174.
 
25.
Krowicki ZK, Burmeister MA, Berthoud HR, Scullion RT, Fuchs K, Hornby PJ: Orexins in rat dorsal motor nucleus of the vagus potently stimulate gastric motor function. Am J Physiol 2002, 283, G465- G472.
 
26.
Baccari MC, Bani D, Calamai F: Evidence for a modulatory role of orexin A on the nitrergic neurotransmission in the mouse gastric fundus. Regul Pept 2009, 154, 54-59.
 
27.
Ehrstrom M, Gustafsson T, Finn A, Kirchgessner A, Gryback P, Jacobsson H, Hellstrom PM, Naslund E: Inhibitory eff ect of exogenous orexin a on gastric emptying, plasma leptin, and the distribution of orexin and orexin receptors in the gut and pancreas in man. J Clin Endocrinol Metab 2005, 90, 2370-2377.
 
28.
Ehrstrom M, Levin F, Kirchgessner AL, Schmidt PT, Hilsted LM, Gryback P, Jacobsson H, Hellstrom PM, Naslund E: Stimulatory eff ect of endogenous orexin A on gastric emptying and acid secretion independent of gastrin. Regul Pept 2005, 132, 9-16.
 
29.
Korczyński W, Ceregrzyn M, Kato I, Woliński J, Zabielski R: The eff ect of orexins on intestinal motility in vitro in fed and fasted rats. J Physiol Pharmacol 2006, 57(Suppl 6), 43-54.
 
30.
Bulbul M, Tan R, Gemici B, Ongut G, Izgut-Uysal VN: Eff ect of orexin-a on ischemia- reperfusion-induced gastric damage in rats. J Gastroenterol 2008, 43, 202-207.
 
31.
Eliassi A, Nazari M, Naghdi N: Role of the ventromedial hypothalamic orexin-1 receptors in regulation of gastric acid secretion in conscious rats. J Neuroendocrinol 2009, 21,177-182.
 
32.
Yamada H, Tanno S, Takakusaki K, Okumura T: Intracisternal injection of orexin-A prevents ethanol-induced gastric mucosal damage in rats. J Gastroenterol 2007, 42, 336-341.
 
33.
Satoh Y, Uchida M, Fujita A, Nishio H, Takeuchi T, Hata F: Possible role of orexin A in nonadrenergic, noncholinergic inhibitory response of muscle of the mouse small intestine. Eur J Pharmacol 2001, 428, 337-342.
 
34.
Yazdani J, Wang I, Song I, Yao H, Owyang C: Functional signifi cance of orexin in rat GI motility: diff erential eff ect of feeding on orexin receptor regulation. Neurogastroenterol Motil 2004, 15, 656.
 
35.
Ehrstrom M, Naslund E, Ma J., Kirchgessner AL, Hellstrom PM: Physiological regulation and NO-dependent inhibition of migrating myoelectric complex in the rat small bowel by OXA. Am J Physiol 2003, 285, G688-G695.
 
36.
Ljung T, Hellstrom PM: Vasoactive intestinal peptide suppresses migrating myoelectric complex of rat small intestine independent of nitric oxide. Acta Physiol Scand 1999, 165, 225-231.
 
37.
Flemstrom G, Sjoblom M, Jedstedt G, Akerman KE: Short fasting dramatically decreases rat duodenal secretory responsiveness to orexin A but not to VIP or melatonin. Am J Physiol 2003, 285, G1091- G1096.
 
38.
Okumura T, Takakusaki K: Role of orexin in central regulation of gastrointestinal functions. J Gastroenterol 2008, 43, 652-660.
 
39.
Satoh Y, Okishio Y, Azuma YT, Nakajima H, Hata F, Takeuchi T: Orexin A aff ects ascending contraction depending on downstream cholinergic neurons and descending relaxation through independent pathways in mouse jejunum. Neuropharmacology 2006, 51, 466-473.
 
40.
Sanger GJ, Kuchai R, Morgan M: Excitatory and inhibitory neuronallymediated actions of orexin-A and melanin-concentrating hormone (MCH) in human isolated colon. Gastroenterology 2001, 120(Suppl 1) A172 (abstract).
 
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