RESEARCH PAPER
Relations between excretion of indole melanogen (TPM) and time of exposure to solar radiation
 
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1
Private Diagnostic Laboratory, Jaworzno, Poland
2
Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland
3
Jan Grodek Higher Vocational State School Medical Institute, Sanok, Poland
4
Jan Grodek Higher Vocational State School in Sanok, Medical Institute, Poland
CORRESPONDING AUTHOR
Wojciech Roczniak   

The Jan Grodek Higher Vocational State School in Sanok, Medical Institute, Mickiewicza 21, 38-500 Sanok, Poland
 
J Pre Clin Clin Res. 2015;9(2):120–123
KEYWORDS
ABSTRACT
Introduction:
In the human skin exposed to ultraviolet (UV) radiation, melanogenesis occurs in two stages, accompanied by urinary excretion of Thormalen-positive melanogen (TPM). In Poland, no data are available on the course and intensity of melanogonesis in relation to UV exposure in an industrial region.

Material and Methods:
The Thormalen test was used for the collected samples (N=136) as modified by Matous and Suchoń.

Results:
Maximum environmental TPM content (0.67 μg/dm3) was observed in August.

Conclusions:
The time of UV exposure and local type of solar radiation promote melanogenesis.

 
REFERENCES (13)
1.
Pathak MA, Kowich J, Fitzpatrick TB. Photobiology of pigment cell. Pigment Cell Ed M Seiji Univ of Tokyo Press 1981: 665–670.
 
2.
Tegner E, Rosman H, Rosengren E. 5-S-Cysteinylodopa and pigment response to UVA light. Acta Dermatovener. Stockholm 1983; 63: 21–25.
 
3.
Toda K, Shono S. Effect of UVA irradiation on the epidermal pigment darkening. Pigment Cell 1979; 4: 318–322.
 
4.
Towpik K. Fizjologiczne i patologiczne reakcje skóry na światło słoneczne. Probl Lek. 1982; 21: 539–551 (in Polish).
 
5.
Walter H. Der zussamenhangvon hautfarbenverteilung ind intensitat der ultravioletten strahlung. Homo 1958; 9: 1–13.
 
6.
Duchoń J, Gregor V. Homovanillic acid and its relation to tyrosine metabolism in melanoma. Clin Chimacta. 1962; 7: 443–445.
 
7.
Duchoń J. Matous B. Dopa and matabolites in melanoma urine. Pigment Cell. 1973; 51: 317–322.
 
8.
Trapeznikov NN, Reukenbakk MO, Ivanowa VD, Jaworsky VB. Clinical evaluationof a method of quantitative determination of homovanillic acid for estimation process in melanoma of the skin. Cancer. 1975; 36: 2064–2068.
 
9.
Matous B, Mechl Z, Sopková B, Duchon J, Pavel S, Budesinska A, Kocent A. The excretion of Thormählen positive melanogens in melanoma patients and its clinical significance. Europ J Cancer. 1980; 16: 383–388.
 
10.
Zgirski A, Gondko R. Obliczenia biochemiczne. PWN Warszawa 1983 (in Polish).
 
11.
Magnus IA. Dermatological Photobiology.Clinical and experimental aspect. Blackwell Scientific Publication. Oxford, London 1976: 126–131.
 
12.
Rosman H, Agrup C, Hansson C, Rosengren E. Biochemical Recorders of Malignant Melanoma. Pigment Cell. 1983; 6: 93–115.
 
13.
Matous B, Budesinska A, Budesinsky M, Duchoń J. Pavel S. The identification of Thormahlen positive melanogen a from urine of patients as 6-metoxy-5-indolylglucosiduronate. Neoplasma 1981; 28: 271–274.
 
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