RESEARCH PAPER
Relations between excretion of indole melanogen (TPM) and time of exposure to solar radiation
| 1 | Private Diagnostic Laboratory, Jaworzno, Poland |
| 2 | Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland |
| 3 | Jan Grodek Higher Vocational State School Medical Institute, Sanok, Poland |
| 4 | Jan Grodek Higher Vocational State School in Sanok, Medical Institute, Poland |
CORRESPONDING AUTHOR
Wojciech Roczniak
The Jan Grodek Higher Vocational State School in Sanok, Medical Institute, Mickiewicza 21, 38-500 Sanok, Poland
The Jan Grodek Higher Vocational State School in Sanok, Medical Institute, Mickiewicza 21, 38-500 Sanok, Poland
J Pre Clin Clin Res. 2015;9(2):120–123
KEYWORDS
ABSTRACT
Introduction:
In the human skin exposed to ultraviolet (UV) radiation, melanogenesis occurs in two stages, accompanied by urinary excretion of Thormalen-positive melanogen (TPM). In Poland, no data are available on the course and intensity of melanogonesis in relation to UV exposure in an industrial region.
Material and Methods:
The Thormalen test was used for the collected samples (N=136) as modified by Matous and Suchoń.
Results:
Maximum environmental TPM content (0.67 μg/dm3) was observed in August.
Conclusions:
The time of UV exposure and local type of solar radiation promote melanogenesis.
In the human skin exposed to ultraviolet (UV) radiation, melanogenesis occurs in two stages, accompanied by urinary excretion of Thormalen-positive melanogen (TPM). In Poland, no data are available on the course and intensity of melanogonesis in relation to UV exposure in an industrial region.
Material and Methods:
The Thormalen test was used for the collected samples (N=136) as modified by Matous and Suchoń.
Results:
Maximum environmental TPM content (0.67 μg/dm3) was observed in August.
Conclusions:
The time of UV exposure and local type of solar radiation promote melanogenesis.
REFERENCES (13)
1.
Pathak MA, Kowich J, Fitzpatrick TB. Photobiology of pigment cell. Pigment Cell Ed M Seiji Univ of Tokyo Press 1981: 665–670.
2.
Tegner E, Rosman H, Rosengren E. 5-S-Cysteinylodopa and pigment response to UVA light. Acta Dermatovener. Stockholm 1983; 63: 21–25.
3.
Toda K, Shono S. Effect of UVA irradiation on the epidermal pigment darkening. Pigment Cell 1979; 4: 318–322.
4.
Towpik K. Fizjologiczne i patologiczne reakcje skóry na światło słoneczne. Probl Lek. 1982; 21: 539–551 (in Polish).
5.
Walter H. Der zussamenhangvon hautfarbenverteilung ind intensitat der ultravioletten strahlung. Homo 1958; 9: 1–13.
6.
Duchoń J, Gregor V. Homovanillic acid and its relation to tyrosine metabolism in melanoma. Clin Chimacta. 1962; 7: 443–445.
7.
Duchoń J. Matous B. Dopa and matabolites in melanoma urine. Pigment Cell. 1973; 51: 317–322.
8.
Trapeznikov NN, Reukenbakk MO, Ivanowa VD, Jaworsky VB. Clinical evaluationof a method of quantitative determination of homovanillic acid for estimation process in melanoma of the skin. Cancer. 1975; 36: 2064–2068.
9.
Matous B, Mechl Z, Sopková B, Duchon J, Pavel S, Budesinska A, Kocent A. The excretion of Thormählen positive melanogens in melanoma patients and its clinical significance. Europ J Cancer. 1980; 16: 383–388.
11.
Magnus IA. Dermatological Photobiology.Clinical and experimental aspect. Blackwell Scientific Publication. Oxford, London 1976: 126–131.
12.
Rosman H, Agrup C, Hansson C, Rosengren E. Biochemical Recorders of Malignant Melanoma. Pigment Cell. 1983; 6: 93–115.
13.
Matous B, Budesinska A, Budesinsky M, Duchoń J. Pavel S. The identification of Thormahlen positive melanogen a from urine of patients as 6-metoxy-5-indolylglucosiduronate. Neoplasma 1981; 28: 271–274.
